“…Among the population-screening studies cited in the AUA guideline, only 1 patient younger than 40 years was clearly reported to have GU cancer 56 ; an additional study reported 1 case of bladder cancer among 30 patients with MH, although this patient's age was not reported. 57 Among 40 referral studies of patients undergoing evaluation for MH, 4 studies clearly identify 6 patients younger than 40 years with GU cancer diagnoses [58][59][60][61] (although 3 of these 4 studies do not provide specific ages) and an additional 15 studies report cancer diagnoses but do not specify whether they occurred in patients younger than 40 years. 23,[62][63][64][65][66][67][68][69][70][71][72][73][74][75] Although a handful of these studies comment on the role of cigarette smoking, none systematically account for all known GU cancer risk factors.…”