Role of Ia-Positive Cells in the Beneficial Effect of Donor Blood Transfusion and Induction of Suppressor Cells in Cardiac Allotransplantation of Rats

Nagata, Michio; Ochiai, Takenori; Asano, Tomohiko; Gunji, Yoshio; Enomoto, Kazuo; Nakajima, Kiyokazu; Uematsu, Taro; Satō, Hiroshi

doi:10.1097/00007890-198411000-00017

Cited by 14 publications

(3 citation statements)

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“…In the case of DST, the prolongation of allograft survival may be due to the appearance of suppressor T cells (9,10), but alloantibodies can clearly contribute to the mechanism of the allograft rejection (12). These factors obviously contribute to allograft tolerance, but we emphasize that the rat donorrecipient combination is the most important factor in effective DST.…”

Section: Treatment Group Graft Survival Periods (Days)mentioning

confidence: 88%

“…In the case of DST, the prolongation of allograft survival may be due to the appearance of suppressor T cells (9,10) …”

Section: Introductionmentioning

confidence: 99%

“…Many factors contribute to the mechanism of allograft tolerance. In the case of DST, the prolongation of allograft survival may be due to the appearance of suppressor T cells (9,10) or to Abbreviations used in this paper: BSA, bovine serum albumin; DST, donor specific transfusion; MHC, major histocompatibility complex; PBS, phosphatebuffered saline; RIA, radioimmunoassay. enhancing antibodies (11).…”

Section: Introductionmentioning

confidence: 99%

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Effect of donor specific transfusion (DST) is restricted to the rat combination used and closely related with alloantibody in heart transplantation

et al. 1989

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SummaryThe effect of donor specific transfusion (DST) in several donor-recipient combinations was examined using the rat heart transplantation model. In some donor-recipient combinations such as LEW to DA, LEW to ACI, LEW to PVG and PVG to DA, DST pretreatment could induce permanent graft survival (> 100 days). But in DA to LEW, ACI to LEW, LEW to BN, BN to LEW, PVG to LEW and BN to DA combinations DST pretreatment had no effect on graft survival. The effect of pre-immunization with several DA antigens (heart, liver, lymph node cells and red blood cells) was examined using the DA to LEW combination in which DST pretreatment was not effective. In no case was permanent graft survival obtained. Alloantibody levels (anti-class I and anti-class I + II, respectively) were analysed at the time of heart transplantation and in the post-transplantation period. The anti-class I antibody levels were low or not detected in rats with surviving grafts, but in the rats which failed to have the prolonged graft survival, anti-class I antibody levels were high. This study showed that the effect of DST was restricted to particular donor-recipient rat combination in the heart transplantation model.

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Section: Treatment Group Graft Survival Periods (Days)mentioning

confidence: 88%

“…In the case of DST, the prolongation of allograft survival may be due to the appearance of suppressor T cells (9,10) …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of donor specific transfusion (DST) is restricted to the rat combination used and closely related with alloantibody in heart transplantation

et al. 1989

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Induction of transplantation tolerance by intravenous injection of allogeneic lymphocytes across an H‐2 class II mismatch. Different mechanisms operate in tolerization across an H‐2 class I vs. H‐2 class II disparity

Twuyver¹,

Kast²,

Mooijaart³

et al. 1990

Eur J Immunol

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Previously, we have shown that the intravenous (i.v.) injection of allogeneic lymphocytes across an H-2 class I-mutant disparity leads to specific skin allograft tolerance caused by irradiation-sensitive donor T cells, which function as veto cells. In the present study, we show that the i.v. injection of H-2 class II-incompatible spleen cells also results in specific skin allograft tolerance. However, tolerance induction depends on the presence of irradiation-resistant non-T cells in the donor cell inoculum. Thus, different mechanisms operate in tolerance induction across an H-2 class I vs. H-2 class II mismatch. I.v. injection of allogeneic spleen cells across an H-2 class I plus class II disparity does not result in skin allograft tolerance. Finally, our data show that transfusion-induced suppression of the delayed-type hypersensitivity response against alloantigens does not correlate with skin allograft tolerance induced by i.v. injected allogeneic lymphocytes. In conclusion, the type of H-2 mismatch between transfusion donor and recipient not only determines the occurrence of allograft tolerance but also the mechanism leading to tolerization.

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Pretransplant cytotoxic conditioning produces effects consistent with clonal deletion mechanisms

Zheng

Johnson²,

Sutherland

1987

Journal of Surgical Research

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Role of Ia-Positive Cells in the Beneficial Effect of Donor Blood Transfusion and Induction of Suppressor Cells in Cardiac Allotransplantation of Rats

Cited by 14 publications

References 0 publications

Effect of donor specific transfusion (DST) is restricted to the rat combination used and closely related with alloantibody in heart transplantation

Effect of donor specific transfusion (DST) is restricted to the rat combination used and closely related with alloantibody in heart transplantation

Induction of transplantation tolerance by intravenous injection of allogeneic lymphocytes across an H‐2 class II mismatch. Different mechanisms operate in tolerization across an H‐2 class I vs. H‐2 class II disparity

Pretransplant cytotoxic conditioning produces effects consistent with clonal deletion mechanisms

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