Role of IGF-1 in goat semen freezing: A Review

Abstract

This review is based on the importance of Insulin-like Growth Factor-1 (IGF-1) in goat semen cryopreservation. Recent studies indicate that certain growth factors determine the seminal quality due to the interaction between seminal plasma and spermatozoa. Cryopreservation is the technique used to preserve semen at extremely low temperatures for extended periods, which is essential for artificial insemination (AI) and selective breeding programs. IGF-I promotes the proliferation and maturation of spermatozoa. IGF-I is involved in sperm motility, DNA fragmentation, membrane integrity and fertilizing capacity. There was a significant positive correlation between the weight of animals and IGF-1 genotype diversity. This review aims to investigate the effect of IGF-1 fortification in semen cryopreservation. Further, the review article also assesses the role of IGF-1 in improving the post-thaw quality and viability of goat semen, with the ultimate goal of enhancing the success rates of AI. The research gap this review aims to fill is the limited understanding of the role of IGF-1 fortification on goat semen cryopreservation.