Role of IL-10 −1082, IFN-γ +874, and TNF-α −308 Genes Polymorphisms in Suicidal Behavior

Omrani, Mir Davood; Bushehri, Behzad; Bagheri, Mohammad; Salarilak, Shaker; Alipour, Azize; Anoshae, Mohamad-Reza; Massomi, Reza

doi:10.1080/13811110903266418

Cited by 32 publications

(17 citation statements)

References 44 publications

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“…Studies of relationships between functional polymorphisms in cytokine genes and suicide attempts are few and do not provide a consensus. Investigations of the functional polymorphism TNF-α -308 (A/G) variously have found no differences in suicide attempters with various psychiatric diagnosis ( n =193) vs. healthy controls ( n =420) (Sáiz et al, 2008); a positive association between the GG genotype and depressed suicide attempters ( n =204) vs. depressed non-attempters ( n =97); and (in a sample with both sexes) greater prevalence in male suicides ( n =28) than in non-psychiatric controls ( n =46) (Omrani et al, 2009). Similarly, one study (Lee and Kim, 2010) of TGF-β1 functional polymorphisms found no differences in either codon 10 or codon 20 polymorphisms in depressed suicide attempters ( n =124) compared with depressed non-attempters ( n =61) or healthy controls ( n =125), whereas another study (Omrani et al, 2012) found the TGF-β1-10 polymorphism to be more prevalent in suicide completers ( n =145) compared to non-psychiatric controls ( n =200).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, one study (Lee and Kim, 2010) of TGF-β1 functional polymorphisms found no differences in either codon 10 or codon 20 polymorphisms in depressed suicide attempters ( n =124) compared with depressed non-attempters ( n =61) or healthy controls ( n =125), whereas another study (Omrani et al, 2012) found the TGF-β1-10 polymorphism to be more prevalent in suicide completers ( n =145) compared to non-psychiatric controls ( n =200). Single reports found the IL-10 -1082 genotype higher in suicides than non-psychiatric controls and the IFN-γ + 874 genotype more prevalent in male suicides (Omrani et al, 2009), and no differences in polymorphisms of the IL-1 gene complex [ IL-1α -889 C/T, IL-1β + 3953 C/T, IL-1RA (86 bp) n ] between a mixed diagnostic group of suicide attempters ( n =193) and healthy controls ( n =420) (Sáiz et al, 2008). …”

Section: Discussionmentioning

confidence: 99%

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The role of cytokines in the pathophysiology of suicidal behavior

Ganança

Oquendo

Tyrka

et al. 2016

Psychoneuroendocrinology

186

128

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Objective Immune dysregulation has been implicated in depression and other psychiatric disorders. What is less clear is how immune dysregulation can affect risk of suicidal behavior. We reviewed the scientific literature concerning cytokines related to suicidal ideation, suicidal behavior and suicide, and surveyed clinical and neurobiological factors associated with cytokine levels that may modulate effects of inflammation on suicide risk. Methods We searched PubMed, Embase, Scopus and PsycINFO for relevant studies published from 1980 through February, 2015. Papers were included if they were written in English and focused on cytokine measurements in patients with suicidal behaviors. Results The literature search yielded 22 studies concerning cytokines and suicidal ideation, suicide attempts or suicide completion. The most consistent finding was elevated interleukin (IL)-6, found in 8 out of 14 studies, in CSF, blood, and postmortem brain. In one study, IL-6 in CSF was also found to be higher in violent than nonviolent attempters and to correlate with future suicide completion. Low plasma IL-2 was observed in 2 studies of suicide attempters, while divergent results were seen for tumor necrosis factor (TNF)-α, interferon (IFN)-γ, transforming growth factor (TGF)-β, IL-4, and soluble Il-2 receptors. Conclusions Given the complexity suggested by the heterogenous cytokine findings, putative mediators and moderators of inflammation on suicidal behavior merit further study. Elevated IL-6 was the most robust cytokine finding, associated with suicidal ideation and both nonfatal suicide attempts and suicides. Future studies should evaluate the predictive value of high IL-6, consider how this may alter brain function to impact suicidal behavior, and explore the potential beneficial effects of reducing IL-6 on suicide risk.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The role of cytokines in the pathophysiology of suicidal behavior

Ganança

Oquendo

Tyrka

et al. 2016

Psychoneuroendocrinology

186

128

View full text Add to dashboard Cite

show abstract

“…Depression is accompanied by elevated levels of cytokines, and immunotherapy with IL-2 or IFN-α precipitates depression that can be attenuated with antidepressant treatment [66,67]. Higher levels of cerebrospinal fluid IL-6 have been associated with violent suicide attempts [68], with mixed findings regarding associations between other cytokine genes and suicidal behavior [69,70]…”

Section: Discussionmentioning

confidence: 99%

Pharmacogenomics of Suicidal Events

Brent¹,

Melhem²,

Turecki

2010

Pharmacogenomics

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Pharmacogenomic studies of antidepressant treatment-emergent suicidal events in depressed patients report associations with polymorphisms in genes involved in transcription (CREB1), neuroprotection (BDNF and NTRK2), glutamatergic and noradrenergic neurotransmission (GRIA3, GRIK2 and ADRA2A), the stress and inflammatory responses (FKBP5 and IL28RA), and the synthesis of glycoproteins (PAPLN). Nearly all of the reported events in these studies were modest one-time increases in suicidal ideation. In 3231 unique subjects across six studies, 424 (13.1%) patients showed increases in suicidal ideation, eight (0.25%) attempted suicide and four (0.12%) completed suicide. Systems related to most of these genes have also been implicated in studies of suicidal behavior irrespective of treatment. Future pharmacogenomic studies should target events that are clinically significant, related clinical phenotypes of response and medication side effects, and biological pathways that are involved in these outcomes in order to improve treatment approaches.

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“…Similarly to our results (concerning rs539689), they found that A allele of the -G308A polymorphism in TNF-α gene increased the susceptibility for schizophrenia only in males. Additionally TNF-α-308G/G genotype has been increased in males with suicide behavior versus control group (Omrani et al 2009), but schizophrenic patients were not included into this study.…”

Section: Discussionmentioning

confidence: 99%

Association of HSPA1B Polymorphisms with Paranoid Schizophrenia in a Polish Population

et al. 2019

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This study aimed to find the potential association between HSPA1B polymorphisms and risk of paranoid schizophrenia, clinical variables of the disease, and suicidal behavior. A total of 901 unrelated Polish subjects of Caucasian origin (377 schizophrenia patients and 524 controls) were recruited. Four single-nucleotide polymorphisms (SNP) were genotyped using PCR-RFLP (rs539689, rs9281590) and TaqMan assays (rs263979, rs6547452). A strong tendency towards statistical significance (p = 0.051) was observed in rs539689 allele distribution between patients and controls in overall study subjects. After stratification according to gender, we found that rs539689 was significantly associated with schizophrenia in males, but not in females. The minor allele C had a protective effect in males [OR 0.73 (95% CI 0.61-0.88, p < 0.05)]. In addition, two SNPs (rs539689, rs9281590) were significantly associated with PANSS scores. Another important finding was a strong significant association between the HSPA1B rs539689 polymorphism and attempted suicide in schizophrenic patients. The C/C genotype and C allele were protective against suicidal behavior in entire sample (p < 0.001), in males (p < 001), and in females (p < 0.05), although associations were weaker than in males. Our findings support that HSPA1B gene may be involved in susceptibility to schizophrenia and clinical presentation of the disease in a sex-dependent manner, and may play a role in suicidal behavior in the Polish population of schizophrenic patients. Further independent analyses in different populations should be performed to clarify the role of HSPA1B in the pathogenesis of schizophrenia.

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Role of IL-10 −1082, IFN-γ +874, and TNF-α −308 Genes Polymorphisms in Suicidal Behavior

Cited by 32 publications

References 44 publications

The role of cytokines in the pathophysiology of suicidal behavior

The role of cytokines in the pathophysiology of suicidal behavior

Pharmacogenomics of Suicidal Events

Association of HSPA1B Polymorphisms with Paranoid Schizophrenia in a Polish Population

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