Role of IL-8, CRP and epidermal growth factor in depression and anxiety patients treated with mindfulness-based therapy or cognitive behavioral therapy in primary health care

Memon, Ashfaque A.; Sundquist, Kristina; Ahmad, Abrar; Wang, Xiao; Hedelius, Anna; Sundquist, Jan

doi:10.1016/j.psychres.2017.05.012

Cited by 52 publications

(58 citation statements)

References 26 publications

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“…EGF is a kind of multifunctional cell growth factor produced by platelets, macrophages and monocytes [16] that plays an important role by binding to epidermal growth factor receptor (EGFR) on cell surfaces [17]. EGFR is expressed on various cell surfaces, including broblasts, endothelial cells and smooth muscle cells, and especially, epidermal cells [18].…”

Section: Introductionmentioning

confidence: 99%

Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs

Wei

Wang

et al. 2020

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Background: Vacuum sealing drainage (VSD) and epidermal growth factor (EGF) both play an important role in the treatment of wounds. This study aims to explore the effect of the combination of VSD and EGF on wound healing and the optimal concentration and time of EGF.Methods: In this study, we tested the proliferation and migration capacity of HaCaT and L929 cells at different EGF concentrations (0, 1, 5, 10, and 100 ng/ml) and different EGF action times (2, 10, and 30min). A full-thickness skin defect model was established using male, 30-week-old Bama pigs. The skin defects were randomly divided follows: routine dressing change after covering with sterile auxiliary material (Control), continuous negative pressure drainage of the wound (VSD), continuous negative pressure drainage of the wound and injection of epidermal growth factor 10 minutes followed by removal by continuous lavage (V+E 10 min), and continuous negative pressure drainage of the wound and injection of epidermal growth factor 30 minutes followed by removal by continuous lavage (V+E 30 min). The wound healing rate, histological repair effect and collagen deposition were compared among the four groups.Results: An EGF concentration of 10 ng/ml and an action time of 10 minutes had optimal effects on the proliferation and migration capacities of HaCaT and L929 cells. The drug dispersion effect was better than drug infusion after bolus injection effect, and the contact surface was wider. Compared with other groups, the V+E 10min group promoted wound healing to the greatest extent and obtained the best histological score. Conclusions: A rhEGF concentration of 10 ng/ml can promote the proliferation and migration of epithelial cells and fibroblasts to the greatest extent in vitro. VSD combined with rhEGF kept in place for 10 minutes and then washed, can promote wound healing better than the other treatments in vivo.

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Section: Introductionmentioning

confidence: 99%

Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs

Wei

Wang

et al. 2020

Preprint

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“…Drainage tubes with multiple side-openings inserted in the wound dressing aspirate the necrotic tissue and exudate in a timely manner, thus reducing the need for antibiotic use (4). Epidermal growth factor (EGF) is a multifunctional cellular growth factor that acts by binding to the epidermal growth factor receptor (EGFR) on the cell surface (5). EGFR is expressed on the cell membrane of epidermal cells, fibroblasts, endothelial cells, and smooth muscle cells.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of combined treatment with vacuum sealing drainage and recombinant human epidermal growth factor for refractory wounds in the extremities and its effect on serum levels of IL-6, TNF-α and IL-2

2017

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The objective of this study was to investigate the efficacy of combined treatment with vacuum sealing drainage (VSD) and recombinant human epidermal growth factor (rhEGF) for refractory wounds in the extremities, and its effect on serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and IL-2. Ninety-eight patients with refractory wounds in the extremities were recruited and randomly divided into the combined treatment group (underwent VSD and rhEGF treatment) and control group (underwent VSD only) with 49 cases each. Formation of granulation tissue on the wound surface was assessed and scored. The wound healing rate was calculated after 1 week of treatment, and the time of complete healing was recorded. Serum levels of IL-6, IL-2, and TNF-α were measured using enzyme-linked immunosorbent assay. After 1 week of treatment, granulation tissue formation on wound surfaces was significantly improved (p<0.05) compared with that before treatment in both groups. Moreover, granulation tissue formation on wound surfaces was superior in the combined treatment group than in the control group (p<0.05). The wound healing rate was 63.50±4.75% in the combined treatment group and 31.79±3.52% in the control group, and the difference was statistically significant (p<0.05). The time of complete healing was 15.11±2.24 days in the combined treatment group and 19.63±2.76 days in the control group, and the difference was statistically significant (p<0.05). The serum levels of IL-6, IL-2, and TNF-α, in the two groups were significantly lower than those before treatment (p<0.05). Moreover, the levels in the combined treatment group were significantly lower than those in the control group (p<0.05). In conclusion, combined treatment with VSD and rhEGF reduced inflammation and shortened the time of complete healing of refractory wounds in the extremities. Measurement of the levels of related inflammatory factors provided a reference for the prognosis of refractory wounds.

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“…Psychological interventions, such as mindfulness-based group therapy (MBGT) or cognitive behavioral therapy (CBT), are effective ways for improving the effects of psychological symptoms and reducing proinflammatory processes (Black and Slavich 2016;Irwin et al 2015;Khoury et al 2013;Memon et al 2017;Sundquist et al 2015). Sundquist et al (2015) found that an 8-week mindfulness-based group therapy or treatment as usual (TAU) (mainly CBT) had clinically meaningful effects on patients with depression and anxiety, and this effect persisted even at the 1-year follow-up (Sundquist et al 2019).…”

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confidence: 99%

“…However, information on biomarkers to predict response to psychotherapeutic interventions in patients with depression or anxiety is scarce. In a recent report, Memon et al (2017) assessed both CRP and the cytokine IL-8 as potential predictive biomarkers for MBGT or TAU, but none was predictive; this suggests that other biomarkers should be explored.…”

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confidence: 99%

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Macrophage Migration Inhibitory Factor as a Predictor for Long-term Improvements After Mindfulness-Based Group Therapy or Treatment as Usual for Depression, Anxiety or Stress and Adjustment Disorders

et al. 2020

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Objectives Identification of biological markers that can guide treatment selection is considered to be a viable solution for personalized treatment for patients with psychiatric disorders. This study investigated whether macrophage migration inhibitory factor (MIF) levels at baseline were associated with mindfulness-based group therapy or cognitive behavioral therapy response in patients with mild to moderate symptoms of depression, anxiety, or stress-and adjustment disorders. Methods A total of 168 patients (aged 21-65 years) with psychiatric disorders were included from a randomized controlled trial. Plasma MIF levels in all the patients were analyzed using Luminex assay. Results Higher MIF levels at baseline were significantly associated with better long-term (1-year follow-up) improvement in psychiatric symptoms, as measured by changes in the Montgomery-Åsberg Depression Rating Scale (MADRS-S), compared with lower MIF levels, after adjustment for baseline MADRS-S score, age, sex, BMI, and pharmacotherapy (β = 5.89, p = 0.001). Patients with higher levels of MIF (8235-23,391 pg/ml) had an almost 6 points' larger decrease in MADRS-S score after 1 year compared with those with lower MIF (727-8223 pg/ml) at baseline. Similar trends were seen after 8 weeks, albeit non-significant (β = 1.99, p = 0.18). Conclusions The findings indicate that higher plasma MIF levels at baseline may predict better long-term outcomes with psychotherapeutic interventions for mild to moderate symptoms of depression, anxiety, or stress and adjustment disorders. MIF levels may serve as a potential biomarker that can guide treatment selection for the personalized treatment for patients with psychiatric disorders.Keywords Macrophage migration inhibitory factor . Depression . Anxiety . Mindfulness-based therapy . Cognitive behavioral therapy Electronic supplementary material The online version of this article (https://doi.

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Role of IL-8, CRP and epidermal growth factor in depression and anxiety patients treated with mindfulness-based therapy or cognitive behavioral therapy in primary health care

Cited by 52 publications

References 26 publications

Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs

Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs

Efficacy of combined treatment with vacuum sealing drainage and recombinant human epidermal growth factor for refractory wounds in the extremities and its effect on serum levels of IL-6, TNF-α and IL-2

Macrophage Migration Inhibitory Factor as a Predictor for Long-term Improvements After Mindfulness-Based Group Therapy or Treatment as Usual for Depression, Anxiety or Stress and Adjustment Disorders

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