Role of immunoglobulin and antibodies in disease management

Megha, K. B.; Mohanan, P.V.

doi:10.1016/j.ijbiomac.2020.12.073

Cited by 61 publications

(28 citation statements)

References 78 publications

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“…In addition, Zhang et al [ 16 ] showed that Lactobacillus plantarum NCU116 fermentation on Asparagus officinalis polysaccharide also had good immunomodulatory activity. Notably, immunoglobulins are the most widely used blood products in clinical practice due to their unique immunomodulatory and anti-inflammatory activities [ 17 ]. Liu et al [ 18 ] found that broccoli residues fermented with probiotics increased the levels of Ig A, Ig G and Ig M in the sera of C. perfringens -infected birds.…”

Section: Discussionmentioning

confidence: 99%

Dietary Vegetable Powders Modulate Immune Homeostasis and Intestinal Microbiota in Mice

Zou

Zhang

et al. 2021

Foods

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As the largest immune organ of the human body, the intestine also plays a vital role in nutrient digestion and absorption. Some vegetables are considered to have improvement effects on the intestine. This experiment explored the effects of freeze-dried asparagus, broccoli and cabbage powder on the intestinal immune homeostasis and microflora of mice. Thirty-two mice were divided into four groups (n = 8), including control group (fed normal diet), asparagus group (fed normal diet with 5% asparagus power), broccoli group (fed normal diet with 5% broccoli power) and cabbage group (fed normal diet with 5% cabbage power). The experiment lasted 21 days. The results showed that the serum immunoglobulin concentration (IgA and IgM) and intestinal cytokine content (like IFN-γ and TNF-α) were increased after vegetable powder supplement. The experiment also detected that vegetable powder supplementation changed intestinal flora and their metabolites (short-chain fatty acid), which showed that the abundance of Lachnospiraceae and Bacteroides were decreased, while the abundance of Firmicutes and Lactobacillus as well as propionic acid and butyric acid contents were increased. Together, these vegetable powders, especially cabbage, changed the intestinal immune response and microbial activity of mice.

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Section: Discussionmentioning

confidence: 99%

Dietary Vegetable Powders Modulate Immune Homeostasis and Intestinal Microbiota in Mice

Zou

Zhang

et al. 2021

Foods

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“…Besides, humoral response is considered being involved largely in host immune reaction during microbial infection. The multi-isotype antibodies in serum include IgA, IgD, IgG, IgM, and IgE, of which IgG is the most abundant, while IgD and IgE are extremely scarce (9). Thus, assessment of antibody responses has been focused on the titers of IgA, IgG, and IgM (10).…”

Section: Introductionmentioning

confidence: 99%

The Characterization of Disease Severity Associated IgG Subclasses Response in COVID-19 Patients

et al. 2021

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Increasing evidence suggests that dysregulated immune responses are associated with the clinical outcome of coronavirus disease 2019 (COVID-19). Nucleocapsid protein (NP)-, spike (S)-, receptor binding domain (RBD)- specific immunoglobulin (Ig) isotypes, IgG subclasses and neutralizing antibody (NAb) were analyzed in 123 serum from 63 hospitalized patients with severe, moderate, mild or asymptomatic COVID-19. Mild to modest correlations were found between disease severity and antigen specific IgG subclasses in serum, of which IgG1 and IgG3 were negatively associated with viral load in nasopharyngeal swab. Multiple cytokines were significantly related with antigen-specific Ig isotypes and IgG subclasses, and IL-1β was positively correlated with most antibodies. Furthermore, the old patients (≥ 60 years old) had higher levels of chemokines, increased NAb activities and SARS-CoV-2 specific IgG1, and IgG3 responses and compromised T cell responses compared to the young patients (≤ 18 years old), which are related with more severe cases. Higher IgG1 and IgG3 were found in COVID-19 patients with comorbidities while biological sex had no effect on IgG subclasses. Overall, we have identified diseases severity was related to higher antibodies, of which IgG subclasses had weakly negative correlation with viral load, and cytokines were significantly associated with antibody response. Further, advancing age and comorbidities had obvious effect on IgG1 and IgG3.

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“…The immune system of the body responds to generating the immunoglobulins known as antibodies to protect against harmful foreign substances, such as an antigen. They are mainly immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin A (IgA), and immunoglobulin D (IgD) [ 162 ]. The quantitative measuring of immunoglobulin is the key to determining the immune response, diagnostics, and health condition of the body against foreign substances [ 163 ].…”

Section: Ionic Liquids–carbon-based Functional Nanomaterials In Biosensing Applicationsmentioning

confidence: 99%

Functional Ionic Liquids Decorated Carbon Hybrid Nanomaterials for the Electrochemical Biosensors

et al. 2021

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Ionic liquids are gaining high attention due to their extremely unique physiochemical properties and are being utilized in numerous applications in the field of electrochemistry and bio-nanotechnology. The excellent ionic conductivity and the wide electrochemical window open a new avenue in the construction of electrochemical devices. On the other hand, carbon nanomaterials, such as graphene (GR), graphene oxide (GO), carbon dots (CDs), and carbon nanotubes (CNTs), are highly utilized in electrochemical applications. Since they have a large surface area, high conductivity, stability, and functionality, they are promising in biosensor applications. Nevertheless, the combination of ionic liquids (ILs) and carbon nanomaterials (CNMs) results in the functional ILs-CNMs hybrid nanocomposites with considerably improved surface chemistry and electrochemical properties. Moreover, the high functionality and biocompatibility of ILs favor the high loading of biomolecules on the electrode surface. They extremely enhance the sensitivity of the biosensor that reaches the ability of ultra-low detection limit. This review aims to provide the studies of the synthesis, properties, and bonding of functional ILs-CNMs. Further, their electrochemical sensors and biosensor applications for the detection of numerous analytes are also discussed.

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Role of immunoglobulin and antibodies in disease management

Cited by 61 publications

References 78 publications

Dietary Vegetable Powders Modulate Immune Homeostasis and Intestinal Microbiota in Mice

Dietary Vegetable Powders Modulate Immune Homeostasis and Intestinal Microbiota in Mice

The Characterization of Disease Severity Associated IgG Subclasses Response in COVID-19 Patients

Functional Ionic Liquids Decorated Carbon Hybrid Nanomaterials for the Electrochemical Biosensors

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