Role of immunohistochemistry in lymphoma

Rao, I. Satish

doi:10.4103/0971-5851.76201

Cited by 30 publications

(38 citation statements)

References 5 publications

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“…In this age group, the commonest type of ML was HL (16 cases, 28%) followed by peripheral T-cell lymphoma (13 cases, 22.8%), precursor lymphoblastic T-cell lymphoma (8 cases, 14%), Burkitt's lymphoma (6 cases, 10.5%), precursor lymphoblastic B-cell lymphoma (6 cases, 10.5%), and others [ Table 4]. There were 42 male and 15 female patients, with a male-female ratio of 2.8:1.…”

Section: Childhood Lymphomamentioning

confidence: 94%

“…The panel of immunohistochemistry (IHC) markers included CD 45 (LCA), CD45RO, CD79, CD20, CD23, CD10, CD5, CD3, CD56, CD4, CD8, CD15, CD30, CD34, EMA, MUM1, BCL6, TdT, BCL2, MIB1/KI67, ALK1, and kappa and lambda light chains. [10,11] Other IHC markers were also utilized if needed for evaluation of some unknown neoplasm/ML. All patients were subjected to routine hematologic (estimation of hemoglobin, total and different leukocyte count, platelet count, peripheral smear for abnormal/blast cells, etc.…”

Section: Methodsmentioning

confidence: 99%

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Malignant lymphoma in Eastern India: A retrospective analysis of 455 cases according to World Health Organisation classification

et al. 2014

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Section: Childhood Lymphomamentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Malignant lymphoma in Eastern India: A retrospective analysis of 455 cases according to World Health Organisation classification

et al. 2014

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“…shows monomorphic intermediate-sized cells with diffuse pattern along with expression of IHC markers 6. …”

mentioning

confidence: 99%

The value of cytology in diagnosis of serous effusions in malignant lymphomas: An experience of a tertiary care center

Patel

Mehta

et al. 2019

Diagnostic Cytopathology

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Background: Malignant lymphomas (ML) are often complicated by serous effusions.The present study is an attempt to cytologically assess a large series of serous effusions associated with ML, identify the immunoreactivity of cells and to evaluate the role of various ancillary methods in confirming and subtyping these cases. Methods: A cross-sectional study of 4612 serous effusions was undertaken at the Department of Cytology, Gujarat Cancer and Research Institute by retrieving data from the year 2015 to 2017. Total 169 cases of ML, clinically suspicious, were included. All cerebrospinal fluids, serous effusions involved by myeloid neoplasms, and cases of primary effusion lymphomas were excluded from our study. Pap stained smears of all these serous effusions were examined. Ancillary methods such as immunohistochemistry were used to further subtype the positive cases using the WHO classification of hematopoietic and lymphoid neoplasms (2016). Results: Out of total 169 clinically suspicious cases, 109 cases were cytologically positive for ML which included 73 (66.9%) pleural effusions, 34 (31.1%) ascitic fluids, and 2 (1.8%) pericardial effusions. T-lymphoblastic lymphoma (36.9%) and Burkitt's lymphoma (38.2%) were the most common ML involving the pleural and ascitic fluids respectively. Non-Hodgkin's lymphoma (NHL) more frequently involved the serous cavities than Hodgkin's lymphoma. (P value <.0001). Among the NHL, T-cell lymphomas more commonly lead to serous effusions than B-cell lymphomas (P value <.0048). Conclusion: Cytological examination of serous effusions is an accurate, prompt, affordable technique having diagnostic and therapeutic implications. With the help of ancillary methods, we can identify the phenotype of cells, classify as well as confirm our diagnosis. K E Y W O R D S immunohistochemistry, malignant lymphomas, serous effusions

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“…In our case histopathological sections of all organs (Lungs, liver, kidney, intestine, ovaries and fallopian tubes) show non Hodgkin's lymphoma with infiltration of bilateral tumor with pulmonary edema with interstitial pneumonitis which may leads to multi organ failure and death. Better understanding of the pathogenesis of lymphomas has become possible with the help of IHC and its careful utilization aids identification and the characterization of immunophenotype in most of the lymphomas [15] . The panel of markers is decided based onmorphologic differential diagnosis (no single marker is specific) which includes leukocyte common antigen (LCA), B-cell markers (CD20 and CD79a), T-cell markers (CD3 and CD5) and other markers like CD23, bcl-2, CD10, cyclinD1, CD15, CD30, ALK-1, CD138 (based on cytoarchitectural pattern).…”

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin’s Lymphoma: A Clinical autopsy case report with review of literature

Sameer¹

2017

JMSCR

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Role of immunohistochemistry in lymphoma

Cited by 30 publications

References 5 publications

Malignant lymphoma in Eastern India: A retrospective analysis of 455 cases according to World Health Organisation classification

Malignant lymphoma in Eastern India: A retrospective analysis of 455 cases according to World Health Organisation classification

The value of cytology in diagnosis of serous effusions in malignant lymphomas: An experience of a tertiary care center

Non-Hodgkin’s Lymphoma: A Clinical autopsy case report with review of literature

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