Role of Immunotyping in Chronic Lymphocytosis: Review of the Natural History of the Condition in 145 Adult Patients

Tefferi, Ayalew; Li, Chin Yang; Phyliky, Robert L.

doi:10.1016/s0025-6196(12)62360-x

Cited by 11 publications

(4 citation statements)

References 23 publications

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“…CD3 was fourrd to be too weak to identify I-cell neoplasms in general, and CD45RO(UCHL-1) weakly stainc-d neutro-phiLs; both strongly stained one T-cell CLL. Their main role was to identify non-specific reactive T-eell inliltrates iu patients with CLL; most of thcr-n are of B-cell origin (17).…”

Section: Discussionmentioning

confidence: 99%

Value of immunohistochemistry in the diagnosis of leukemia cutis: study of 54 cases using paraffin‐section markers

Ratnam

Ziesmer

et al. 1992

J Cutan Pathol

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A grave prognosis is usually associated with leukemic skin infiltrates (leukemia cutis). However, some leukemic skin infiltrates are clinically similar to reactive non-leukemic infiltrates in patients with leukemia; thus it is of great importance to distinguish them. Fifty-four cases which were thought clinically to be leukemia cutis underwent immunophenotyping with a panel of nine T, B, monocytic, and macrophage markers using paraffin sections. Immunohistochemistry helped identify 44 cases with leukemia cutis and 10 with reactive infiltrates. In all cases of leukemia cutis, the staining patterns of skin infiltrates were concordant with cell type in the bone marrow. Furthermore, the panel of markers was usually helpful in distinguishing reactive from leukemia infiltrates, especially in cases with chronic lymphatic leukemia. Immunohistochemistry is a valuable adjunct in histopathologic differentiation of skin infiltrates in most cases of leukemia. With formalin-fixed, paraffin-embedded biopsies, we recommend that CD45 (LCA), CD45RO (UCHL-1), CD3, CD20 (L-26), CD43 (Leu-22), CD68 (KP-1), lysozyme, and chloroacetate esterase be considered in cases of systemic leukemia with cutaneous papules and nodules that prove difficult to interpret with routine section.

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Section: Discussionmentioning

confidence: 99%

Value of immunohistochemistry in the diagnosis of leukemia cutis: study of 54 cases using paraffin‐section markers

Ratnam

Ziesmer

et al. 1992

J Cutan Pathol

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“…Such processes may be derived from B-cell, T-cell, or natural killer cell lineage. 114 However, the PBS has limited value in the differential diagnosis of lymphocytosis; we recommend, in addition, immunophenotyping by flow cytometry in all such cases. The immunophenotypic profile that accompanies the myriad of chronic lymphoid leukemia is outlined in Table 4 as a resource for the hematologist.…”

Section: Lymphocytosismentioning

confidence: 96%

“…Lymphocytosis with normal-appearing small-lymphocyte morphology suggests B-cell chronic lymphocytic leukemia. 114 A spectrum of other morphologic abnormalities characterize other lymphoid neoplasms including acute leukemia (leukemic blasts could be mistaken for lymphocytes) or chronic lymphoid leukemias that are not chronic lymphocytic leukemia (Table 4). Such processes may be derived from B-cell, T-cell, or natural killer cell lineage.…”

Section: Lymphocytosismentioning

confidence: 99%

How to Interpret and Pursue an Abnormal Complete Blood Cell Count in Adults

Tefferi

Hanson

Inwards

2005

Mayo Clinic Proceedings

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138

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A complete blood cell count (CBC) is one of the most common laboratory tests in medicine. For example, at our institution alone, approximately 1800 CBCs are ordered every day, and 10% to 20% of results are reported as abnormal. Therefore, it is in every clinician's interest to have some understanding of the specific test basics as well as a structured action plan when confronted with abnormal CBC results. In this article, we provide practical diagnostic algorithms that address frequently encountered conditions associated with CBC abnormalities including anemia, thrombocytopenia, leukopenia, polycythemia, thrombocytosis, and leukocytosis. The objective is to help the nonhematologist recognize when a subspecialty consultation is reasonable and when it may be circumvented, thus allowing a cost-effective and intellectually rewarding practice.

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“…Histologically, dense monomorphic collections of small, mature lymphocytes with only occasional mitosis are seen. In over 95% of cases the neoplastic cells are B lymphocytes 12 . The immune system is thus markedly impaired and these patients are predisposed to predictable complications including pancytopenia, secondary infections, and other malignancies.…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma in a Patient with Chronic Lymphocytic Leukemia

Albregts

Orengo

Salasche

et al. 1998

Dermatologic Surgery

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CLL is a malignancy that primarily effects the elderly population and markedly increases their risk of developing skin cancers, especially SCC. An intense infiltrate may be present surrounding the tumor. This case report demonstrates one of the potential challenges the Mohs surgeon may face in interpreting histologic frozen section. Immunohistochemistry may be helpful in providing a more definitive answer to this problem.

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Role of Immunotyping in Chronic Lymphocytosis: Review of the Natural History of the Condition in 145 Adult Patients

Cited by 11 publications

References 23 publications

Value of immunohistochemistry in the diagnosis of leukemia cutis: study of 54 cases using paraffin‐section markers

Value of immunohistochemistry in the diagnosis of leukemia cutis: study of 54 cases using paraffin‐section markers

How to Interpret and Pursue an Abnormal Complete Blood Cell Count in Adults

Squamous Cell Carcinoma in a Patient with Chronic Lymphocytic Leukemia

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