Role of imprint cytology in intraoperative diagnosis: value and limitations.

Suen, Kenneth C.; Wood, William S.; Syed, A A; Quenville, Noel F.; Clement, Philip B.

doi:10.1136/jcp.31.4.328

Cited by 95 publications

(78 citation statements)

References 11 publications

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“…Following this, several studies which were done in the past have discussed the use of imprint and touch preparations, especially as a tool for making the intraoperative diagnoses [4][5][6]. Few studies have documented ovarian cytological features in the imprint smears which were obtained during intraoperative procedures [7][8][9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Utility of Intraoperative Cytology in the Management of Ovarian Tumours

Vijayakumar¹

2013

JCDR

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Background: The present study was done to evaluate the status of intraoperative cytology as a diagnostic and supportive investigation for ovarian tumours. Materials and Methods:The present study was conducted in the Department of Pathology, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India during a time span of 13 months (June 2011 to June 2012). A prospective investigation was performed on 50 cases of suspected ovarian neoplasms. Imprint smears were made intraoperatively from fresh samples from various representative areas, and they were immediately fixed in 95% ethyl alcohol and stained with the haematoxylin and eosin stain. The results were compared with the final histopathological diagnoses in each case.Results: There were 20 benign lesions, 4 borderline epithelial neoplasms and 26 malignant tumours according to the final histopathological diagnosis. The overall diagnostic accuracy of imprint cytology has been satisfactory, with those of 90% of the cases correlating with the final diagnoses. Characteristic cytological patterns were noted in various surface epithelial, sex cord stromal and germ cell tumours. Conclusion:Imprint cytology can be used as an adjunct to histopathology for a rapid and an early diagnosis in the operation theatre, particularly in developing countries like ours, where the facility of frozen sections is often not available, since a rapid preliminary diagnosis may help in the surgical management planning.

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Section: Discussionmentioning

confidence: 99%

The Diagnostic Utility of Intraoperative Cytology in the Management of Ovarian Tumours

Vijayakumar¹

2013

JCDR

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“…Since the introduction of imprint cytology for surgical pathology by DUDGEON and PATRICK [8] in 1927, this technique has been widely accepted as an adjunct to frozen section histopathology for intra-operative diagnosis [9][10][11][12][13]. With the exception of intra-operative diagnosis, imprint cytology has been used to obtain a rapid diagnosis for intra-abdominal lesions [14] and core biopsy of breast, as well as bronchoscopic forcep biopsies.…”

Section: Discussionmentioning

confidence: 99%

“…Intra-operative cytology of touch preparations has been used as an alternative to frozen section since it was first reported in 1927 [8][9][10][11][12][13]. This method has been utilised to obtain immediate cytological diagnosis for core needle and bronchoscopic forcep biopsies [14][15][16].…”

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confidence: 99%

Value of imprint cytology for ultrasound-guided transthoracic core biopsy

Liao¹

2004

Eur Respir J

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The aim of this study was to investigate the possible additional diagnostic information provided by imprint cytology when performing ultrasound-guided transthoracic core biopsy and to evaluate whether it could optimise the biopsy procedure.A total of 155 transthoracic core biopsies with touch imprint smears were performed under ultrasound guidance, with 127 malignant and 28 benign lesions. The imprint smears were stained using Riu9s method and interpreted by a cytopathologist. These were compared with the histopathology of core biopsy specimens and the final diagnosis of malignant versus benign disease.The overall diagnostic accuracy of imprint cytology was 94% (146 out of 155). Histopathological analysis showed an overall accuracy of 94% (146 out of 155), with a sensitivity of 94% (119 out of 127) and negative predictive value of 79% (27 out of 34). The combination of these two methodologies had an increased overall accuracy and negative predictive value of 98% (152 out of 155) and 90% (28 out of 31), respectively. The results of imprint cytology and histopathology were in agreement in 143 patients (92%).In conclusion, imprint cytology of ultrasound-guided transthoracic core biopsy is a sensitive procedure for diagnosing peripheral thoracic lesions, and it may increase the diagnostic accuracy and cancer negative prediction of biopsy alone. With an on-site approach, imprint cytology may help to assess the adequacy of biopsy specimens and optimise the biopsy procedure. Eur Respir J 2004; 24: 905-909.

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“…The potential advantages of cytology preparations include the relative ease and rapidity with which slide preparations can be made, the reduced requirement for diagnostic material, and the enhanced cellular detail without artifacts related to tissue freezing. [14][15][16][17][18][19] Cytology preparations also require less technical expertise than frozen section and, therefore, are less dependent upon the availability of experienced technical staff. Furthermore, potentially infective preparations can be assessed cytologically without contamination of cryostat facilities.…”

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confidence: 99%

“…[14][15][16][17][18] Cytology specimens may be obtained using needle sampling of resected surgical specimens (''bench aspirates''), by direct touch imprints, or by scraping and smearing cellular material from the cut surface of the tumor on to slides. The potential advantages of cytology preparations include the relative ease and rapidity with which slide preparations can be made, the reduced requirement for diagnostic material, and the enhanced cellular detail without artifacts related to tissue freezing.…”

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confidence: 99%

Value of cytology in the intraoperative assessment of ovarian tumors

Stewart

Brennan

Koay

et al. 2010

Cancer Cytopathology

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BACKGROUND:Intraoperative pathological assessment is frequently requested in patients with suspected ovarian neoplasia so that optimal surgical management can be performed. In this study the accuracy of intraoperative cytology has been assessed and the results compared with frozen section diagnosis.METHODS:The study comprised 402 ovarian tumors that were submitted for intraoperative assessment in which both cytology preparations, usually scrape smears, and conventional frozen sections were examined. Each technique was evaluated independently, although the diagnosis transmitted to the surgeon was based upon the combination of the clinical, macroscopic, histological, and cytological information. The results were compared with the final pathological diagnosis in each case and cases with discordant diagnoses were reviewed.RESULTS:There were 226 benign lesions, 35 borderline epithelial neoplasms, and 141 malignant tumors according to the final pathological diagnosis. All benign lesions were accurately categorized using both frozen section and cytology. Thirty (86%) of the borderline tumors and 137 (97%) of the malignant tumors were accurately identified on frozen section, whereas the corresponding results for cytology were 23 (66%) and 131 (93%), respectively. There were no false‐positive diagnoses with either technique and the overall accuracy was 97.8%. Cytological evaluation provided better morphologic detail, permitted wider tumor sampling, and directed appropriate ancillary investigations in some cases.CONCLUSIONS:Overall, frozen section was more accurate than smear preparations in this series. However, cytology has a complementary role in the intraoperative assessment of ovarian neoplasia and provides a more specific diagnosis in some cases. Cancer (Cancer Cytopathol) 2010. © 2010 American Cancer Society.

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Role of imprint cytology in intraoperative diagnosis: value and limitations.

Cited by 95 publications

References 11 publications

The Diagnostic Utility of Intraoperative Cytology in the Management of Ovarian Tumours

The Diagnostic Utility of Intraoperative Cytology in the Management of Ovarian Tumours

Value of imprint cytology for ultrasound-guided transthoracic core biopsy

Value of cytology in the intraoperative assessment of ovarian tumors

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