Role of insulin sensitizers in the management of polycystic ovary syndrome

Rashid, Owais; Fatima, Mahwish

doi:10.1016/b978-0-323-87932-3.00026-8

Polycystic Ovary Syndrome 2024

DOI: 10.1016/b978-0-323-87932-3.00026-8

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Role of insulin sensitizers in the management of polycystic ovary syndrome

Owais Rashid¹,

Mahwish Fatima²

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Cited by 2 publications

References 9 publications

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Nanoparticles drug delivery for 5-aminolevulinic acid (5-ALA) in photodynamic therapy (PDT) for multiple cancer treatment: a critical review on biosynthesis, detection, and therapeutic applications

Bhattacharya,

Prajapati,

Singh

et al. 2023

J Cancer Res Clin Oncol

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Nanoparticles drug delivery for 5-aminolevulinic acid (5-ALA) in photodynamic therapy (PDT) for multiple cancer treatment: a critical review on biosynthesis, detection, and therapeutic applications

Bhattacharya,

Prajapati,

Singh

et al. 2023

J Cancer Res Clin Oncol

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Vitexin isolated from Acanthus ilicifolius L. leaf enhances GLUT-4 translocation in experimental diabetic rats

Gayathri,

Kavya,

Ashwini

et al. 2023

Aquacult Int

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Acanthus ilicifolius L. leaf is extensively used in the Indian and Chinese medicine systems to treat diabetes mellitus. In this study, the antidiabetic effect of vitexin isolated from A.ilicifolius leaf extract and their effect on GLUT-4 translocation and PPAR-γ expression was evaluated high-fat dietstreptozotocinocin (HFD-STZ) induced rats. In vitro antidiabetic effect of vitexin was investigated through glucose uptake activity in L6 (rat skeletal muscle) cell lines. Vitexin (10 and 20 mg/kg BW was administered orally to HFD-STZ-induced diabetic rats for 48 days. The effect of vitexin on body weight, fasting blood glucose, serum insulin, total protein, urea, creatinine, and liver enzymes was examined. GLUT-4 translocation and PPAR-γ expression were studied in the skeletal muscle and adipocytes of experimental rats. The interaction of vitexin with GLUT-4 and PPAR-γ was validated by molecular docking analysis. Vitexin signi cantly lowered the blood glucose and also normalized other biochemical parameters. Further, the treatment with vitexin up-regulates the mRNA expression of GLUT-4 and PPAR-γ in diabetic rats. In silico analysis also supports the promising interactions between vitexin and target proteins. These results explained that vitexin up-regulates the mRNA expression of GLUT-4 and PPAR-γ and enhanced the translocation of GLUT-4 which maintains glucose homeostasis. Thus vitexin can be a gold promising drug for type II diabetes mellitus in the future.

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Role of insulin sensitizers in the management of polycystic ovary syndrome

Cited by 2 publications

References 9 publications

Nanoparticles drug delivery for 5-aminolevulinic acid (5-ALA) in photodynamic therapy (PDT) for multiple cancer treatment: a critical review on biosynthesis, detection, and therapeutic applications

Nanoparticles drug delivery for 5-aminolevulinic acid (5-ALA) in photodynamic therapy (PDT) for multiple cancer treatment: a critical review on biosynthesis, detection, and therapeutic applications

Vitexin isolated from Acanthus ilicifolius L. leaf enhances GLUT-4 translocation in experimental diabetic rats

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