Role of Interferon-Stimulated Gene Factor 3γ and Beta Interferon in HLA Class I Enhancement in Synovial Fibroblasts upon Infection with<i>Chlamydia trachomatis</i>

Rödel, Jürgen; Vogelsang, Heinz; Prager, Katrin; Hartmann, Matthias; Schmidt, Karl‐Hermann; Straube, Eberhard

doi:10.1128/iai.70.11.6140-6146.2002

Cited by 8 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6C). In agreement with our previous findings (34,35), we found that C. trachomatis induces the release of IFN-␤ from human primary fibroblasts (3.5 Ϯ 3.1 IU/ml at 48 h after infection, n ϭ 3), which is known to play a critical role in the induction of MHC I expression (36). The addition of neutralizing antibodies directed against (Fig.…”

Section: Resultssupporting

confidence: 80%

Chlamydia trachomatis-Infected Epithelial Cells and Fibroblasts Retain the Ability To Express Surface-Presented Major Histocompatibility Complex Class I Molecules

et al. 2014

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 80%

Chlamydia trachomatis-Infected Epithelial Cells and Fibroblasts Retain the Ability To Express Surface-Presented Major Histocompatibility Complex Class I Molecules

et al. 2014

View full text Add to dashboard Cite

“…Viral infection caused the production of interferon and the subsequent ISGs in the infected cells (Kim et al, 1997;Levy et al, 2011;Garcia-Del-Barco et al, 2021). Meanwhile, ISGs played various diverse roles in maintaining immunologic homeostasis and controlling pathogens (Künzi and Pitha, 1996;Rödel et al, 2002;Schneider et al, 2014). Our previous study showed that several ISGs positively regulated interferon response (Cheng et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Large Screening Identifies ACE2 Positively Correlates With NF-κB Signaling Activity and Targeting NF-κB Signaling Drugs Suppress ACE2 Levels

Yan

Dong

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Coronaviruses SARS-CoV-2 infected more than 156 million people and caused over 3 million death in the whole world, therefore a better understanding of the underlying pathogenic mechanism and the searching for more effective treatments were urgently needed. Angiotensin-converting enzyme 2 (ACE2) was the receptor for SARS-CoV-2 infection. In this study, we found that ACE2 was an interferon-stimulated gene (ISG) in human cell lines. By performing an ISG library screening, we found that ACE2 levels were positively regulated by multiple ISGs. Interestingly, ACE2 levels were highly correlated with ISGs-induced NF-κB activities, but not IFNβ levels. Furthermore, using an approved clinical durgs library, we found two clinical drugs, Cepharanthine and Glucosamine, significantly inhibited ACE2 level, IFNβ level, and NF-κB signaling downstream TNFα and IL6 levels. Our finding suggested the possible inhibitory effects of Cepharanthine and Glucosamine during SARS-CoV-2 infection and the subsequent inflammatory cytokine storm.

show abstract

Section: Discussionmentioning

confidence: 99%

DataSheet1.xlsx

View full text Add to dashboard Cite

Role of Interferon-Stimulated Gene Factor 3γ and Beta Interferon in HLA Class I Enhancement in Synovial Fibroblasts upon Infection withChlamydia trachomatis

Cited by 8 publications

References 33 publications

Chlamydia trachomatis-Infected Epithelial Cells and Fibroblasts Retain the Ability To Express Surface-Presented Major Histocompatibility Complex Class I Molecules

Chlamydia trachomatis-Infected Epithelial Cells and Fibroblasts Retain the Ability To Express Surface-Presented Major Histocompatibility Complex Class I Molecules

Large Screening Identifies ACE2 Positively Correlates With NF-κB Signaling Activity and Targeting NF-κB Signaling Drugs Suppress ACE2 Levels

DataSheet1.xlsx

Contact Info

Product

Resources

About