Role of interleukin-10 gene polymorphisms in the development of coronary artery disease in Chinese population

Hm, Xu; Yr, Liu

doi:10.4238/2015.december.1.38

Cited by 5 publications

(1 citation statement)

References 25 publications

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“…One such gene possibly associated with HCC is IL-10. Previous studies have reported associations between polymorphisms of this gene and the development of cancers, as well as several other diseases, including acute pancreatitis, coronary artery disease, and colorectal, gastric, oral, lung, esophageal, and breast cancers (Miteva et al, 2014;Qi et al, 2014;Hsu et al, 2015;Jia et al, 2015;Kumar et al, 2015;Vinod et al, 2015;Xu and Liu, 2015;Yang and Fa, 2015;Zhang et al, 2015b). For instance, Miteva et al (2014) reported that the IL-10 -1082A/G polymorphism has a significant impact on the development of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma

Liu

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/ C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain reaction-restriction fragment length polymorphism assay was applied to assess the sequence variants of interest. Compared with control subjects, HCC patients were more likely to be older (t = 1.94, P = 0.03), have a family history of cancer (chi square = 17.86, P < 0.001), and exhibit higher alanine transaminase (t = 13.32, P < 0.001) and aspartate transaminase (t = 12.63, P < 0.001) levels. Using unconditional logistic regression analyses, we found that the GG genotype of -592G/A was associated with increased risk of HCC [odds ratio (OR) = 2.20, 95% confidence interval (CI) = 1.12-4.38], compared to the AA genotype. Under a dominant model, the AG+GG genotype correlated with HBV-related HCC susceptibility compared to the AA genotype, with an OR (95%CI) of 1.56 (1.02-2.48). Moreover, a recessive model showed the GG genotype to be associated with elevated risk of HCC compared to the AA+AG genotype (OR = 1.85, 95%CI = 1.01-3.47). However, no significant association between the -819T/C and -1082A/C variants and development of HBV-related HCC was observed under codominant, dominant, and recessive models. We conclude that the IL-10 -592G/A polymorphism does play a role in susceptibility to HBV-related HCC under codominant, dominant, and recessive models.

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