Role of Interleukin 28B rs12979860 C/T Polymorphism on the Histological Outcome of Chronic Hepatitis C: Relationship with Gender and Viral Genotype

Falleti, Edmondo; Bitetto, Davide; Fabris, Carlo; Cussigh, Annarosa; Fornasiere, Ezio; Cmet, Sara; Fumolo, Elisa; Bignulin, S.; Fontanini, Elisabetta; Cerutti, Andrea; Minisini, Rosalba; Pirisi, Mario; Toniutto, Pierluigi

doi:10.1007/s10875-011-9547-1

Cited by 71 publications

(63 citation statements)

References 28 publications

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“…Similarly, (Asselah et al, 2012) were not able to find any significant relationship between IL28B rs12979860 polymorphism and fibrosis stage or disease severity, though they reported a significant correlation between IL28B rs12979860 polymorphism and treatment. However, some recent studies showed that the IL-28B rs12979860 T/T genotype is an independent predictor of a higher fibrosis staging score compared to the CC or CT genotypes (Agundez et al, 2010;Falleti et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

IL28B rs12979860 Gene Polymorphism in Egyptian Patients with Chronic Liver Disease Infected with HCV

Zekri¹,

Salama²,

Medhat³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Egypt has one of the highest prevalences of hepatitis C virus (HCV) infection worldwide. Although the IL28B gene polymorphism has been shown to modify the course of chronic HCV infection, this has not been properly assessed in the Egyptian population. Materials and Methods: The IL28B rs12979860 single nucleotide polymorphism (SNP) was therefore examined in 256 HCV-infected Egyptian patients (group II) at different stages of disease progression and in 48 healthy volunteers (group I). Group II was subdivided into GII-A (chronic hepatitis patients, n=119), GII-B (post hepatitis cirrhosis, n=66) and GII-C (HCC on top of cirrhosis, n=71). Results: The C/T genotype was the commonest in all groups. It was more frequent in GI (52%) than in GII (48%). There was no significant difference in the frequency of C/T and C/C or T/T genotypes between groups and subgroups (p=0.82). Within the subgroups; the C/C genotype was more common in GII-B while C/T and T/T genotypes were more common in GII-C, though with no significant difference (p=0.59 and p=0.80). There was no significant association between IL28B rs12979860 SNP and viral load, ALT, AFP level, METAVIR scores for necro-inflammation and fibrosis, and Child-Pugh classification. Conclusions: 1) IL28Brs12979860 C/T genotype is the commonest genotype in HCV-associated CH and HCC in Egypt. 2) IL28Brs12979860 polymorphisms are not associated with disease progression or aggression (histological staging, severity of fibrosis in CH or the incidence of post-HCV HCC). 3) Differences in IL28Brs12979860 genotypes could be a consequence of environmental or ethnic variation.

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Section: Discussionmentioning

confidence: 99%

IL28B rs12979860 Gene Polymorphism in Egyptian Patients with Chronic Liver Disease Infected with HCV

Zekri¹,

Salama²,

Medhat³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…We excluded patients who had other chronic liver diseases, positive hepatitis B surface antigen (HBsAg) and human immunodeficiency virus (HIV). The liver biopsies taken percutaneously were evaluated using the Ishak scoring system (22), which categorizes fibrosis with a score of 0-2 as mild, 3-4 as moderate and 5-6 as severe (23). Subjects in the healthy control group had a mean age of 52.5±11.5 years (age range 18-70) and none had any hepatic disease (i.e., infection, long term drug use, autoimmune-hepatitis or alcohol consumption) or endocrine disease and the results of their liver function tests and liver ultrasonography were normal.…”

Section: Patients and Healthy Subjectsmentioning

confidence: 99%

Characterization of the Interleukin-28B Gene rs12979860 C/T Polymorphism in Turkish Chronic Hepatitis C Patients and Healthy Individuals

Taheri¹,

Aygen²,

Korkmaz³

et al. 2015

Balkan Med J

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Background: Host genetic factors can affect the progress of hepatitis-C virus (HCV) infection. Interleukin-28B (IL28B) single nucleotide polymorphisms may play an important role in the clearance of HCV spontaneously or with treatment. Aims: The aim of our study was to evaluate the rate of IL28B genotypes in patients with Chronic Hepatitis-C (CHC) and healthy control subjects and to examine the characteristics of patients in each IL28B subgroup. Study Design: Case-control study. Methods: IL28B polymorphisms were genotyped by Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP) in all subjects. Results: The mean age was 52.3±10.9 years (33% female) in the CHC patients and 52.5±11.5 years (39.1% female) in the healthy controls. The percentage of patients with a high baseline viral load (≥400,000 IU/mL) was higher in the CT group (69.8%) compared to the C/C (44.4%) and T/T (50%) groups (p=0.021). There was no significant difference in liver fibrosis and liver necroinflammation distribution among the CC, CT and TT genotypes with mild, moderate and severe groups (p=0.058 and p=0.791, respectively). Mean age, gender ratio, body mass index, viral load at baseline, rate of HCV genotypes, baseline ALT levels were not significantly different among the three IL28B subgroups (p>0.05). A significant increase was observed in the frequencies of IL28B rs12979860 TT genotypes in the CHC patients (20.6%) compared to the healthy control group (8.7%) (p=0.033). Conclusion: In the patients with chronic HCV-genotype 1b and 4 infections, the IL28B rs12979860 (C>T) gene polymorphism frequency of the TT genotype and T allele was higher than in healthy control subjects. This result indicates that the TT genotype may be more effective in the progression of HCV infection than other genotypes.

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“…After our selection, 7 casecontrol studies including 1152 HCC and/or LC cases and 1326 controls fulfilled the inclusion criteria (Barreiro et al, 2011;Fabris et al, 2011;Falleti et al, 2011;Agundez et al, 2012;El-Awady et al, 2012;Eurich et al, 2012;Ren et al, 2012). The quality of the studies was considered acceptable for our meta-analysis.…”

Section: Study Characteristicsmentioning

confidence: 99%

Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis

Suo¹,

Zhao²

2013

Genet. Mol. Res.

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ABSTRACT. We examined the association of the interleukin-28B (IL-28B) gene rs12979860 T/C polymorphism with development of hepatitis virus-related hepatocellular car cinoma (HCC) and liver cirrhosis (LC). Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library, and Chinese National Knowledge Infrastructure data bases. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) for rs12979860 and HCC/LC were cal culated in a fixed-effect model (the Mantel-Haenszel method) and a random-effect model (the DerSimonian and Laird method) when appropriate. This meta-analysis included 7 eligible studies, with 1152 HCC and/or LC cases and 1326 controls. Overall, the rs12979860 T/C polymorphism was significantly as sociated with risk of hepatitis virusrelated HCC and LC development (TT vs CC+CT, pooled OR = 1.597, 95%CI = 1.254-2.036). When they were grouped by type of hepatitis virus, similar results were found for hepatitis C virus-related groups (TT vs CC+CT, pooled OR = 1.732, 95%CI = 1.343-2.235, P value < 0.0001). In the overall analysis, the IL-28B rs12979860 T/C polymorphism was 3709 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (3): 3708-3717 (2013) 28B gene polymorphism and hepatocellular cancer identified as a genetic risk factor for hepatitis virus-related HCC and LC development. A significant increase in the frequency of the T/T genotype was detected from chronic hepatitis to HCC and LC.

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Role of Interleukin 28B rs12979860 C/T Polymorphism on the Histological Outcome of Chronic Hepatitis C: Relationship with Gender and Viral Genotype

Abstract: IL-28B rs12979860 C/T polymorphism is associated with a greater likelihood of HCV persistence, particularly in HCV genotypes 1 and 4. The T allele affects the severity of liver fibrosis.

Cited by 71 publications

References 28 publications

IL28B rs12979860 Gene Polymorphism in Egyptian Patients with Chronic Liver Disease Infected with HCV

IL28B rs12979860 Gene Polymorphism in Egyptian Patients with Chronic Liver Disease Infected with HCV

Characterization of the Interleukin-28B Gene rs12979860 C/T Polymorphism in Turkish Chronic Hepatitis C Patients and Healthy Individuals

Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis

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