Role of Intestinal Dysbiosis and Nutrition in Rheumatoid Arthritis

Attur, M.; Scher, Jose U.; Abramson, Steven B.; Attur, Mukundan

doi:10.3390/cells11152436

Cited by 35 publications

(25 citation statements)

References 102 publications

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“…It is also reasonable to expect that in certain cases the oral microbiome and mucosal immunity serve a protective function and mediate systemic resolution of inflammation at distal sites. For example, nutrition-mediated influences on the composition of oral microbiome may serve as positive and negative regulators of systemic homeostasis, as has been reported for the gut microbiome (21).…”

Section: Oral Microbiome and Systemic Health And Diseasementioning

confidence: 84%

Oral-systemic immune axis: Crosstalk controlling health and disease

Lumelsky

2023

Front. Dent. Med

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Section: Oral Microbiome and Systemic Health And Diseasementioning

confidence: 84%

Oral-systemic immune axis: Crosstalk controlling health and disease

Lumelsky

2023

Front. Dent. Med

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“…Substantial studies on the pathophysiology of RA indicate that activation of inflammatory signaling pathways may result in alternation of immune system and onset of disease ( Figure 4 ). The aberrant inflammatory signaling pathways in RA development are featured as the imbalance between anti-inflammation and pro-inflammation and induced by the alterations in the profile of Th1 cells ( Attur et al, 2022 ). Recently, the biological roles of G-protein-coupled receptor (GPCRs), including chemokine receptors, melanocortin receptors, lipid metabolism-related receptors, adenosine receptors and other inflammation related receptors, have been demonstrated in the pathogenesis of RA in inflammation, lipid metabolism, angiogenesis, and bone destruction ( Zhao et al, 2022 ).…”

Section: The Protective Activity Of Genistein Against Bone and Cartil...mentioning

confidence: 99%

The protective activity of genistein against bone and cartilage diseases

Liu

2022

Front. Pharmacol.

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Genistein, a natural isoflavone rich in soybean and leguminous plants, has been shown various biological effects, such as anti-inflammation, anti-oxidation, anti-cancer, and bone/cartilage protection. Due to the structural similarity to estrogen, genistein exhibits estrogen-like activity in protecting against osteoporosis and osteoarthritis. Furthermore, genistein has been considered as an inhibitor of tyrosine kinase, which has been found to be dysregulated in the pathological development of osteoporosis, osteoarthritis, and intervertebral disc degeneration (IDD). Many signaling pathways, such as MAPK, NF-κB, and NRF2/HO-1, are involved in the regulatory activity of genistein in protecting against bone and cartilage diseases. The potential molecular mechanisms of genistein in therapeutic management of bone and cartilage diseases have been investigated, but remain to be fully understood. In this article, we mainly discuss the current knowledge of genistein in protecting against bone and cartilage diseases, such as osteoporosis, osteoarthritis, rheumatoid arthritis (RA), and IDD.

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“…The autoimmune condition known as rheumatoid arthritis (RA) results from a combination of genetic and environmental factors [1]. This led to the decision to broaden the study's focus to encompass environmental aspects, including the gut microbiota, as a potential contributor to the onset of RA [2].…”

Section: Introductionmentioning

confidence: 99%

Exploring the significance of microbiota metabolites in rheumatoid arthritis: uncovering their contribution from disease development to biomarker potential

Lu,

Hsu,

Younis

et al. 2024

APMIS

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Rheumatoid arthritis (RA) is a multifaceted autoimmune disorder characterized by chronic inflammation and joint destruction. Recent research has elucidated the intricate interplay between gut microbiota and RA pathogenesis, underscoring the role of microbiota‐derived metabolites as pivotal contributors to disease development and progression. The human gut microbiota, comprising a vast array of microorganisms and their metabolic byproducts, plays a crucial role in maintaining immune homeostasis. Dysbiosis of this microbial community has been linked to numerous autoimmune disorders, including RA. Microbiota‐derived metabolites, such as short‐chain fatty acids (SCFAs), tryptophan derivatives, Trimethylamine‐N‐oxide (TMAO), bile acids, peptidoglycan, and lipopolysaccharide (LPS), exhibit immunomodulatory properties that can either exacerbate or ameliorate inflammation in RA. Mechanistically, these metabolites influence immune cell differentiation, cytokine production, and gut barrier integrity, collectively shaping the autoimmune milieu. This review highlights recent advances in understanding the intricate crosstalk between microbiota metabolites and RA pathogenesis and also discusses the potential of specific metabolites to trigger or suppress autoimmunity, shedding light on their molecular interactions with immune cells and signaling pathways. Additionally, this review explores the translational aspects of microbiota metabolites as diagnostic and prognostic tools in RA. Furthermore, the challenges and prospects of translating these findings into clinical practice are critically examined.

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Role of Intestinal Dysbiosis and Nutrition in Rheumatoid Arthritis

Cited by 35 publications

References 102 publications

Oral-systemic immune axis: Crosstalk controlling health and disease

Oral-systemic immune axis: Crosstalk controlling health and disease

The protective activity of genistein against bone and cartilage diseases

Exploring the significance of microbiota metabolites in rheumatoid arthritis: uncovering their contribution from disease development to biomarker potential

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