The protective activity of genistein against bone and cartilage diseases

Wu, Zhenyu; Liu, Luying

doi:10.3389/fphar.2022.1016981

Cited by 15 publications

(10 citation statements)

References 118 publications

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“…Clinically, symptom relief becomes the effective strategy to treat OA. TNFα and IL-1βplay a central role in the pathological development of OA [127]. The inhibition of inflammatory responses is an effective therapeutic strategy for managing OA.…”

Section: The Protective Activities Of Naringin Against Osteoarthritis...mentioning

confidence: 99%

The Development of Naringin for Use against Bone and Cartilage Disorders

Gan

Deng

et al. 2023

Molecules

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Bone and cartilage disorders are the leading causes of musculoskeletal disability. There is no absolute cure for all bone and cartilage disorders. The exploration of natural compounds for the potential therapeutic use against bone and cartilage disorders is proving promising. Among these natural chemicals, naringin, a flavanone glycoside, is a potential candidate due to its multifaceted pharmacological activities in bone and cartilage tissues. Emerging studies indicate that naringin may promote osteogenic differentiation, inhibit osteoclast formation, and exhibit protective effects against osteoporosis in vivo and in vitro. Many signaling pathways, such as BMP-2, Wnt/β-catenin, and VEGF/VEGFR, participate in the biological actions of naringin in mediating the pathological development of osteoporosis. In addition, the anti-inflammatory, anti-oxidative stress, and anti-apoptosis abilities of naringin also demonstrate its beneficial effects against bone and cartilage disorders, including intervertebral disc degeneration, osteoarthritis, rheumatoid arthritis, bone and cartilage tumors, and tibial dyschondroplasia. Naringin exhibits protective effects against bone and cartilage disorders. However, more efforts are still needed due to, at least in part, the uncertainty of drug targets. Further biological and pharmacological evaluations of naringin and its applications in bone tissue engineering, particularly its therapeutic effects against osteoporosis, might result in developing potential drug candidates.

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Section: The Protective Activities Of Naringin Against Osteoarthritis...mentioning

confidence: 99%

The Development of Naringin for Use against Bone and Cartilage Disorders

Gan

Deng

et al. 2023

Molecules

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“… Fang et al (2018) reported the inhibitory effect of wogonin on IL-1β-induced inflammatory factors and enzymes that promote ECM degradation; in addition, these authors also observed that wogonin upregulated the expression of type II collagen. Genistein, a flavonoid extracted from soybean, has been shown to be effective in preventing osteoarthritis and osteoporosis ( Wu and Liu, 2022 ). In IDD, genistein was shown to increase the secretion of type II collagen and aggrecan and reduce the expression of inflammatory factors by inhibiting the P38 MAPK pathway ( Ge et al, 2020 ) ( Figure 4 ).…”

Section: The Application Of Natural Products To Control Inflammationmentioning

confidence: 99%

Natural products can modulate inflammation in intervertebral disc degeneration

Liu

Zhu²,

Liu³

et al. 2023

Front. Pharmacol.

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Intervertebral discs (IVDs) play a crucial role in maintaining normal vertebral anatomy as well as mobile function. Intervertebral disc degeneration (IDD) is a common clinical symptom and is an important cause of low back pain (LBP). IDD is initially considered to be associated with aging and abnormal mechanical loads. However, over recent years, researchers have discovered that IDD is caused by a variety of mechanisms, including persistent inflammation, functional cell loss, accelerated extracellular matrix decomposition, the imbalance of functional components, and genetic metabolic disorders. Of these, inflammation is thought to interact with other mechanisms and is closely associated with the production of pain. Considering the key role of inflammation in IDD, the modulation of inflammation provides us with new options for mitigating the progression of degeneration and may even cause reversal. Many natural substances possess anti-inflammatory functions. Due to the wide availability of such substances, it is important that we screen and identify natural agents that are capable of regulating IVD inflammation. In fact, many studies have demonstrated the potential clinical application of natural substances for the regulation of inflammation in IDD; some of these have been proven to have excellent biosafety. In this review, we summarize the mechanisms and interactions that are responsible for inflammation in IDD and review the application of natural products for the modulation of degenerative disc inflammation.

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“…The study involving ultrasonication resulted in a high encapsulation efficiency of over 95%, but in vivo assays have not been performed. The second study involved a formulation containing medium chain triglycerides (MCT) oil as a medium and a combination of cholecalciferol and genistein (a polyphenolic isoflavone, that along with its many other effects, , also stimulates bone formation and inhibits resorption, thus positively affecting osteoporosis and osteoarthritis). As in the studies discussed above, in vivo investigations have not been performed.…”

Section: Noninvasive and Microinvasive Delivery Routesmentioning

confidence: 99%

Noninvasive and Microinvasive Nanoscale Drug Delivery Platforms for Hard Tissue Engineering

Stoilov,

Truong,

Gronthos

et al. 2023

ACS Appl. Bio Mater.

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Bone tissue plays a crucial role in protecting internal organs and providing structural support and locomotion of the body. Treatment of hard tissue defects and medical conditions due to physical injuries, genetic disorders, aging, metabolic syndromes, and infections is more often a complex and drawn out process. Presently, dealing with hard-tissue-based clinical problems is still mostly conducted via surgical interventions. However, advances in nanotechnology over the last decades have led to shifting trends in clinical practice toward noninvasive and microinvasive methods. In this review article, recent advances in the development of nanoscale platforms for bone tissue engineering have been reviewed and critically discussed to provide a comprehensive understanding of the advantages and disadvantages of noninvasive and microinvasive methods for treating medical conditions related to hard tissue regeneration and repair.

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The protective activity of genistein against bone and cartilage diseases

Cited by 15 publications

References 118 publications

The Development of Naringin for Use against Bone and Cartilage Disorders

The Development of Naringin for Use against Bone and Cartilage Disorders

Natural products can modulate inflammation in intervertebral disc degeneration

Noninvasive and Microinvasive Nanoscale Drug Delivery Platforms for Hard Tissue Engineering

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