Role of intestinal metaplasia in the histogenesis of gastric carcinoma.

Abstract

SUMMARY Recent evidence suggests that intestinal metaplasia (IM) cannot be regarded as a single entity. A simple classification of IM and its variants based on histological and mucin histochemical criteria was devised, and the incidence of IM subtypes in cancerous and benign gastrectomy specimens was recorded. A particular subtype was associated with 'intestinal' cancers but not with tumours considered to arise in normal gastric epithelium (P < 0-01) or with benign lesions (P < 0 01). This subtype appeared to lack absorptive cells at light microscopic level and secreted both neutral and acid mucins, including marked amounts of sulphomucin but no O-acetyl sialomucin.

Barrett’s Esophagus and Cardiac Intestinal Metaplasia: Two Conditions within the Same Spectrum

“…In contrast, CIM secondary to H pylori infection tends to produce complete IM. Incomplete IM was found to be associated with an increased risk for cancer (26) and is considered a premalignant lesion in the distal stomach (27,28). Similarly, incomplete IM was found to be associated with adenocarcinoma of the esophagus, arising within a background of BE (29).…”

Evaluation of p62c-myc in benign and malignant gastric epithelia

“…The surface epithelium in histological sections of normal stomach, active superficial gastritis with foveolar hyperplasia, chronic superficial gastritis and atrophic gastritis both with and without intestinal metaplasia were examined using the streptavidin-biotin immunoperoxidase assay. Those sections showing intestinal metaplasia were also stained for sulphomucin using the high iron diamine technique in order to subclassify those in which type 2b metaplasia was present (Jass, 1980). The results are presented in Table II.…”

A inter-relação das sialomucinas (antígenos Tn e Stn) com o adenocarcinoma no esôfago de Barrett

“…A adição do ácido siálico forma o antígeno sialosyl-Tn (Stn), produto final que não sofre nova glicosilação. Ambos os antígenos são considerados "antígenos associados a tumor" e seu acúmulo identificaria a glicosilação aberrante, um fenômeno associado ao câncer [7][8][9][11][12][13] .…”