Role of Intramarrow Penetration in Osseous Repair: A Pilot Study in the Rabbit Calvaria

Majzoub, Zeina; Berengo, Mario; Giardino, Roberto; Aldini, N. Nicoli; Cordioli, Giampiero

doi:10.1902/jop.1999.70.12.1501

Cited by 56 publications

(63 citation statements)

References 21 publications

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“…Among the current methods, onlay grafting with autogenous bone blocks is the most frequently used technique, thus considered the gold standard for vertical augmentation of alveolar bones. [16][17][18][19] Utilization of MSCs in alveolar bone augmentation procedures has been proposed to become a significant alternative to autogenous bone blocks, as bone harvesting is avoided with their application. MSCs are undifferentiated cells that have the capacity to differentiate into osteoblasts; thus, the graft material that is applied concomitant with MSCs would have osteogenic capacity as it occurs with ABGs.…”

Section: Discussionmentioning

confidence: 99%

“…4,23 There are also significant number of studies, in which MSCs were obtained from other sources such as adipose tissue or periosteum, applied with sophisticated tissue engineering methods, and used successfully for different types of augmentation procedures such as sinus floor augmentation, socket preservation, and simultaneous guided bone regeneration procedures. 19,24,25 Animal studies, in which MSCs have been used for onlay bone augmentation, usually report positive outcomes. A study by Zigdon-Giladi et al 3 evaluated bone regeneration capacity of bone marrow-derived MSCs in the rat calvarium model.…”

Section: Discussionmentioning

confidence: 99%

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Vertical Bone Augmentation Using Bone Marrow–Derived Stem Cells

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Vertical Bone Augmentation Using Bone Marrow–Derived Stem Cells

et al. 2016

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“…This finding concurs with studies in which a titanium device (e.g., a cap, dome, or cylinder) was used to evaluate the potential for new bone formation. [18][19][20][21][22][23][24][25][26] Among the rabbits in this study, newly generated tissue occupied 92-99% of the total possible space created by the caps after 4 months of healing with or without IP. This is similar to the results (80-97%) from several 3-month studies that used the same titanium cap model.…”

Section: Discussionmentioning

confidence: 99%

Effect of Ipriflavone on Osteoblasts and Osteoclasts during Guided Bone Augmentation

Yagi

Ono

Minegishi

et al. 2007

JOURNAL OF HEALTH SCIENCE

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We investigated the effect of ipriflavone (IP) on osteoblasts and osteoclasts during guided bone augmentation (GBA). Each of ten rabbits had two titanium caps placed into its calvarium for GBA. The animals were divided into two groups: No-IP and IP (IP orally, 10 mg/kg daily after GBA). One cap was removed from each rabbit after 3 months, and the remaining cap served as a control. One month after the removal, all of the animals were euthanized, and histologic and histomorphometric analyses were performed. The tissue generated at the test site in the two groups was resorbed, and its original shape and volume were not maintained 1 month after cap removal. In particular, roughly 20% of the newly generated tissue in the No-IP group was resorbed (72.9 ±2.6% vs. 92.4 ±3.3%, p < 0.05), while approximately 8% was resorbed in the IP group. Furthermore, more osteoblast-like cells were present in the IP group than in the No-IP group (44.4 ± 3.05 vs. 30.2 ± 3.11, p < 0.05), and the proportion of osteoclast-like cells was reduced in the IP group compared to the No-IP group (0.59±0.02 vs. 0.76±0.06, p < 0.05). Therefore, the amount of mineralized tissue generated appeared to increase as the total IP dose increased. Within the limitations of this experimental model, we conclude that daily intake of IP after GBA inhibits the resorption of the augmented tissue and may be useful for improving the quality of newly generated bone beyond the skeletal envelope.

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“…Algunos estudios han demostrado mayor porcentaje de neoformación ósea al realizar perforaciones corticales como parte de la ROG (6,7,15). De manera contraria, otras investigaciones indican que dicha regeneración ocurriría sin previas perforaciones (8,(16)(17)(18); siendo por lo tanto un tema controversial.…”

Section: Perforaciones Corticalesunclassified

Perforaciones corticales penetraciones intramedulares y decorticaciones en regeneración ósea guiada

Carrillo

López

Acevedo

2017

C.Odont

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Artículo de revisiónLas perforaciones corticales, penetraciones intramedulares o decorticaciones se realizan a menudo como parte del procedimiento de regeneración ósea guiada (ROG). Su sustento biológico se basa en que mejorarían la angiogénesis y proporcionarían una vía hacia el hueso esponjoso rico en vasos sanguíneos.También se consideran como un "noxious stimuli" (estímulo nocivo) que iniciaría el fenómeno regional acelerado con una respuesta local exuberante facilitando la cicatrización ósea normal. Además, mejorarían la unión o enlace físico entre el injerto óseo y el lecho receptor asegurando estabilidad y fusión de los bloques óseos. Sin embargo, se nos presentan algunas interrogantes relacionadas a su fundamento, a los términos que las describen, a los tamaños, a su cantidad y disposición, al instrumental adecuado para realizarlas y al confort del paciente. Palabras clave: "regeneración ósea, cicatrización de heridas, neovascularización fisiológica"Cortical perforations, intramedullary penetrations or decortications are often performed as part of the guided bone regeneration (GBR) procedure. Their biological basis is that they would improve angiogenesis, providing a pathway to the medullar bone rich of blood vessels. In addition, cortical perforations would be consider as a "noxious stimuli" that initiate the accelerated regional phenomenon with an exuberant local response facilitating normal bone healing. Moreover, they would improve the physical bonding between the bone graft and the recipient bed ensuring stability and fusion of the bone blocks. However, there are some questions related to its foundation, terms to describe them, their sizes, quantity and disposition, the appropriate instruments to perform them and the comfort of the patient.

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Role of Intramarrow Penetration in Osseous Repair: A Pilot Study in the Rabbit Calvaria

Abstract: Within the limits of this study, the results demonstrate that intramarrow penetration accelerates initial bone neogenesis and results in increased bone fill and density, suggesting that its use can be beneficial in bone regenerative procedures.

Cited by 56 publications

References 21 publications

Vertical Bone Augmentation Using Bone Marrow–Derived Stem Cells

Vertical Bone Augmentation Using Bone Marrow–Derived Stem Cells

Effect of Ipriflavone on Osteoblasts and Osteoclasts during Guided Bone Augmentation

Perforaciones corticales penetraciones intramedulares y decorticaciones en regeneración ósea guiada

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