Role of ischemia-modified albumin in the evaluation of oxidative stress in intrahepatic cholestasis of pregnancy

Tayyar, Ahter Tanay; Kozalı, Şükran; Yıldırım, Gonca Yetkin; Karakuş, Resul; Yüksel, İlkbal Temel; Erel, Özcan; Neşeli̇oğlu, Salim; Eroğlu, Mustafa

doi:10.1080/14767058.2018.1474871

Cited by 10 publications

(10 citation statements)

References 28 publications

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“…In the presence of hypoxia and increased oxidative stress, the N-terminus of albumin changes, reducing its metal-binding ability, and a new form of albumin, IMA, is formed [9]. Studies have shown increased IMA levels in patients with preeclampsia, pregnancy cholestasis, and hyperemesis gravidarum [29][30][31]. In our study IMA level between groups was similar.…”

Section: Discussionsupporting

confidence: 60%

Umbilical Cord Blood CK-MB, Troponin T, ProBNP, IMA Levels, and Fetal Cardiac Function in Cases of IUGR

Turgut

Özdemir

Narlı

et al. 2022

Preprint

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Objective: To evaluate umbilical cord blood creatine kinase MB (CK-MB), Troponin T (TnT-hs), pro-brain natriuretic peptide (proBNP), ischemia modified albumin (IMA) levels and fetal cardiac function in intrauterine growth retardation (IUGR). Methods: The study included 39 pregnant women with IUGR and 42 healthy pregnant women in control group. IUGR was diagnosed when estimated fetal weight was <10 percentile. Fetal cardiac function was evaluated by ultrasound in third trimester of pregnancy and compared with control group. Umbilical cord blood biochemical test (CK-MB, TnT-hs, proBNP, IMA) results compared between the groups. Results: In cardiac morphological evaluation, cardiothoracic index was higher and left sphericity index was lower in the IUGR group compared to the control group (p<0,001, p=0,018). Left myocardial performance index (MPI) was higher, tricuspid and mitral annular plane systolic excursion (TAPSE and MAPSE) values were lower in IUGR group than control group (p=0,035, p=0,038 and p=0,011 respectively). In IUGR group only proBNP levels was increased compare to control group in umbilical cord blood biochemical tests (p=0,018). There was negative correalation between umbilical cord blood proBNP levels and MAPSE value (r=-0,332, p=0,002). Conclusions: We observed that IUGR was associated with fetal cardiac morphological changes and systolic dysfunction. Also, in IUGR group cord blood proBNP level was increased and negatively correlated with MAPSE value.

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Section: Discussionsupporting

confidence: 60%

Umbilical Cord Blood CK-MB, Troponin T, ProBNP, IMA Levels, and Fetal Cardiac Function in Cases of IUGR

Turgut

Özdemir

Narlı

et al. 2022

Preprint

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“…The formation of reactive oxygen species (ROS) and free radicals temporarily changes the N-terminal region of albumin, which causes an increase in IMA concentration ( 7 ) . Furthermore, it has been shown to increase in the healthy pregnant women and other pregnancy-related situations ( 8 , 9 , 10 ) .…”

Section: Introductionmentioning

confidence: 99%

The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis

Onat¹,

Kırmızı²,

Başer³

et al. 2020

tjod

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Objective: Preeclampsia (PE) is a dangerous complication of pregnancy and still a major cause of maternal-fetal morbidity and mortality. Its etiology remains largely unknown, but researchers have suggested oxidative stress-mediated inflammation for the same. The purpose of this study is to investigate the relationship between oxidative stress and PE as well as the usability of oxidative stress indicators such as serum ischemia-modified albumin (IMA) levels and thiol/disulfide balance in the prediction of PE. Materials and Methods: The study included 47 pregnant women with PE and 57 healthy pregnant women. We measured their serum IMA, native thiol, total thiol, and disulfide levels. Additionally, we determined the optimal cutoff values via the receiver operating characteristic curve analysis. Results: There were no differences between the two groups with respect to the maternal age, body mass index, gravida, and parity. The native and total thiol levels were found to be low when the disulfide and IMA levels were high in the patients with PE (p<0.05). When the IMA level was corrected by the albumin level (IMAR), the significant difference between the two groups disappeared. We also found that the native and total thiol concentrations were correlated with the systolic and diastolic blood pressures. The optimal cut-off values calculated for the prediction of PE were as follows: 178.45 µmol/L (with sensitivity of 72% and specificity of 83%) for native thiol, 232.55 µ mol/L (with a sensitivity of 75% and specificity of 85%) for total thiol, and 29.05 µmol/L (with sensitivity of 65% and specificity of 72%) for disulfide. Conclusion: The balance of thiol/disulfide may play a role in the pathogenesis of PE and could be used as a biological marker for PE.

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“…Most scholars consider that the pathogenesis of this disease is notably correlated with maternal bile acid level, especially the CG level in the body of pregnant women (3). Long-term high bile acid level, especially high CG level will cause significant spasm in vessels on the surface of placental villi (4), and the increased resistance caused by it will lead to reduced blood flow passing through the area of placenta intervillous space and decreased oxygenation (4), and further bring about insufficient fetal perfusion (5), functional hypoxia-ischemia, difficulty in transshipment of oxygen molecules and nutrient substance from maternal circulation. This will finally result in intrauterine fetal distress and affect growth and development of fetuses (6).…”

Section: Introductionmentioning

confidence: 99%

Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes

Wang

Zhou

et al. 2019

Exp Ther Med

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The effects of intrahepatic cholestasis of pregnancy (ICP) on hepatic function, changes of inflammatory cytokines and fetal outcomes were studied. In total, 663 pregnant women admitted to Daqing Longnan Hospital from July 2016 to December 2017 were selected. There were, 40 cases with ICP enrolled in the observation group, and 40 normal pregnant women were recruited in the normal group. They were also grouped according to hepatic function and inflammatory cytokines, with 40 cases in each group. Neonatal Apgar scores were recorded. The correlations of serum cholylglycine (CG) in pregnant women with umbilical artery systolic-to-diastolic (S/D) ratio in the third trimester of pregnancy, the alanine aminotransferase level, the high-sensitivity C-reactive protein (hs-CRP) level, neonatal Apgar score and gestational week were analyzed. The birth weight in the observation group was lighter than that in the normal group (P<0.05); the gestational week at birth was earlier than that in the normal group (P<0.05); Apgar score at birth was lower than that in the normal group (P<0.05), and the levels of inflammatory cytokines were higher than those in the control group (P<0.05). Apgar scores of newborns at birth and at 1 and 5 min after birth in the normal hepatic function and normal inflammatory cytokine groups were higher than those in the abnormal hepatic function group (P<0.05). The serum CG level in pregnant women was positively correlated with umbilical artery S/D ratio, the alanine aminotransferase level and the hs-CRP level in the third trimester of pregnancy, but negatively correlated with neonatal Apgar score and gestational week. Among patients with ICP, the higher the GG level in the body is, the higher the alanine aminotransferase, inflammatory cytokine and umbilical artery S/D ratio will be, which may cause lower neonatal Apgar score, neonatal asphyxia and premature delivery.

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Role of ischemia-modified albumin in the evaluation of oxidative stress in intrahepatic cholestasis of pregnancy

Abstract: Serum IMA levels did not differ between pregnant women with ICP and healthy pregnant women, while the IMAR was significantly higher in the ICP group versus the healthy pregnant women.

Cited by 10 publications

References 28 publications

Umbilical Cord Blood CK-MB, Troponin T, ProBNP, IMA Levels, and Fetal Cardiac Function in Cases of IUGR

Umbilical Cord Blood CK-MB, Troponin T, ProBNP, IMA Levels, and Fetal Cardiac Function in Cases of IUGR

The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis

Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes

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