Role of Link N in Modulating Inflammatory Conditions

Yang, Mu Chen; Wang, Ding Han; Cherng, Juin Hong; Li, Wan Chun; Lin, Po‐Yen; Hsu, Wun Eng; Hsu, Ming Lun

doi:10.11607/ofph.1952

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent in vivo study has provided evidence that LN can prevent OA lesion development or progression in vivo in a rabbit model of OA (Antoniou et al, 2019). LN was also found to modulate inflammation and stimulate the repair of arthritis-mediated temporomandibular joint disruption in vivo (Yang et al, 2019). Delivery of synthetic LN-encoding mRNA into primary human chondrocytes and mesenchymal stromal cells results in an enhanced expression of aggrecan, Sox9 and Col II (Tendulkar et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Link N suppresses interleukin-1β-induced biological effects on human osteoarthritic cartilage

Alaqeel¹,

Mp²,

Lm³

et al. 2020

eCM

View full text Add to dashboard Cite

Osteoarthritis (OA) is a disease of diarthrodial joints associated with extracellular matrix proteolytic degradation under inflammatory conditions, pain and disability. Currently, there is no therapy to prevent, reverse or modulate the disease course. The present study aimed at evaluating the regenerative potential of Link N (LN) in human OA cartilage in an inflammatory milieu and determining if it could affect pain-related behaviour in a knee OA mouse injury model. Osteo-chondro OA explants and OA chondrocytes were treated with LN in the presence of interleukin-1β (IL-1β) to simulate an osteoarthritic environment. Quantitative von Frey polymerase chain reaction and Western blotting were performed to determine the effect of LN on matrix protein synthesis, catabolic enzymes, cytokines and nerve growth factor expression. Partial medial meniscectomy (PMM) was performed on the knee of C57BL/6 mice and, 12 weeks post-surgery, mice were given a 5 µg intra-articular injection of LN or phosphate-buffered saline. A von Frey test was conducted over 24 h to measure the mechanical allodynia in the hind paw. LN modulated proteoglycan and collagen synthesis in human OA cartilage through inhibition of IL-1βinduced biological effects. LN also supressed IL-1β-induced upregulation of cartilage-degrading enzymes and inflammatory molecules in OA chondrocytes. Upon investigation of the canonical signalling pathways IL-1β and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), LN resulted to significantly inhibit NF-κB activation in a dose-dependent manner. In addition, LN suppressed mechanical allodynia in an OA PMM mouse model. Results supported the concept that LN administration could have therapeutic potential in OA.

show abstract

Section: Discussionmentioning

confidence: 99%

Link N suppresses interleukin-1β-induced biological effects on human osteoarthritic cartilage

Alaqeel¹,

Mp²,

Lm³

et al. 2020

eCM

View full text Add to dashboard Cite

show abstract

“…The most cited paper (67 citations in WoS-CC, 5,07%) was by Wu et al in 2014, entitled “The pilot study of fibrin with temporomandibular joint derived synovial stem cells in repairing TMJ disc perforation” [ 36 ], and published in the journal “BioMed research international” which deals with a pilot study for the use of scaffold fibrin/chitosan hybrids and mesenchymal stem cells, to evaluate the repair of the TMJ joint disc. Twelve articles received only one citation [ 11 , 18 , 28 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. Ten articles were not cited in Wos-CC [ 27 , 29 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ].…”

Section: Resultsmentioning

confidence: 99%

Global Trends and Future Research Directions for Temporomandibular Disorders and Stem Cells

Silva

Melo

Ferreira

et al. 2023

JFB

View full text Add to dashboard Cite

Temporomandibular disorder (TMD) is an umbrella term used to describe various conditions that affect temporomandibular joints, masticatory muscles, and associated structures. Although the most conservative and least invasive treatment is preferable, more invasive therapies should be employed to refractory patients. Tissue engineering has been presented as a promising therapy. Our study aimed to investigate trends and point out future research directions on TMD and stem cells. A comprehensive search was carried out in the Web of Science Core Collection (WoS-CC) in October 2022. The bibliometric parameters were analyzed through descriptive statistics and graphical mapping. Thus, 125 papers, published between 1992 and 2022 in 65 journals, were selected. The period with the highest number of publications and citations was between 2012 and 2022. China has produced the most publications on the subject. The most frequently used keywords were “cartilage”, “temporomandibular joint”, “mesenchymal stem cells”, and “osteoarthritis”. Moreover, the primary type of study was in vivo. It was noticed that using stem cells to improve temporomandibular joint repair and regeneration is a significant subject of investigation. Nonetheless, a greater understanding of the biological interaction and the benefits of using these cells in patients with TMD is required.

show abstract

Effects of food hardness on temporomandibular joint osteoarthritis: Qualitative and quantitative micro-CT analysis of rats in vivo

Ngoc

Wang

Yang

et al. 2023

Annals of Anatomy - Anatomischer Anzeiger

View full text Add to dashboard Cite

Role of Link N in Modulating Inflammatory Conditions

Cited by 3 publications

References 0 publications

Link N suppresses interleukin-1β-induced biological effects on human osteoarthritic cartilage

Link N suppresses interleukin-1β-induced biological effects on human osteoarthritic cartilage

Global Trends and Future Research Directions for Temporomandibular Disorders and Stem Cells

Effects of food hardness on temporomandibular joint osteoarthritis: Qualitative and quantitative micro-CT analysis of rats in vivo

Contact Info

Product

Resources

About