Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training

Murphy, E. Angela; Davis, James H.; Brown, Adrienne S.; Carmichael, Martin D.; Rooijen, Nico van; Ghaffar, Abdul; Mayer, Eugene P.

doi:10.1152/ajpregu.00274.2004

Cited by 43 publications

(38 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, clodronate could have other unknown pharmacological effects that can affect compliance through mechanisms not involving macrophages. However, the use of clodronate is an effective and well-accepted technique for macrophage depletion and has been used successfully in many models (19,35,39). Also, we cannot completely eliminate the possibility that the clodronate may have been contaminated with endotoxin and thus participate in a preconditioning effect that could be protective against I/R.…”

Section: Discussionmentioning

confidence: 99%

Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury

Zhao¹,

Fernández²,

Doctor³

et al. 2006

American Journal of Physiology-Lung Cellular and Molecular Phys

173

146

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury

Zhao¹,

Fernández²,

Doctor³

et al. 2006

American Journal of Physiology-Lung Cellular and Molecular Phys

173

146

View full text Add to dashboard Cite

show abstract

“…This technique has not yet been used in studies involving exercise stress or any form of ␤-glucan. However, using this technique, we have recently shown an important role of macrophages on the beneficial effects of moderate exercise on susceptibility to infection (25).…”

mentioning

confidence: 99%

“…Altered susceptibility to infection will be measured as changes in morbidity (time to sickness), symptom severity, and mortality (time to death). This was done using a murine model of exercise, respiratory infection (3,4,10,12), and in vivo lung macrophage depletion (25). The exercise protocol consisted of three consecutive days of prolonged treadmill running to fatigue designed to mimic a short period of severe exercise training.…”

mentioning

confidence: 99%

Benefits of oat β-glucan on respiratory infection following exercise stress: role of lung macrophages

Murphy

Davis²,

Brown³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

Self Cite

View full text Add to dashboard Cite

Exercise stress is associated with an increased risk for upper respiratory tract infection (URTI). We have shown that consumption of the soluble oat fiber β-glucan (OβG) can offset the increased risk for infection and decreased macrophage antiviral resistance following stressful exercise; however, the direct role of macrophages is unknown. This study examined the effect of macrophage depletion on the benefits of orally administered OβG on susceptibility to infection (morbidity, symptom severity, and mortality) following exercise stress. CL2MDP (Ex- H2O-CL2MDP, Ex-OβG-CL2MDP, Con-H2O-CL2MDP, Con-OβG-CL2MDP)-encapsulated liposomes were administered intranasally to deplete macrophages, and PBS (Ex-H2O-PBS, Ex-OβG-PBS, Con-H2O-PBS, Con-OβG-PBS)-encapsulated liposomes were given to macrophage-intact groups. Ex mice ran to volitional fatigue on a treadmill for 3 consecutive days, and OβG mice were fed a solution of 50% OβG in their drinking water for 10 consecutive days before infection. Fifteen minutes following the final bout of Ex or rest, mice were intranasally inoculated with 50 μl of a standardized dose of herpes simplex virus-1. Ex increased morbidity ( P < 0.001) and symptom severity ( P < 0.05) but not mortality ( P = 0.09). The increase in morbidity and symptom severity was blocked by OβG consumption for 10 consecutive days before exercise and infection [morbidity ( P < 0.001) and symptom severity ( P < 0.05)]. Depletion of macrophages negated the beneficial effects of OβG on reducing susceptibility to infection following exercise stress, as evidenced by an increase in morbidity ( P < 0.01) and symptom severity ( P < 0.05). Results indicate that lung macrophages are at least partially responsible for mediating the beneficial effects of OβG on susceptibility to respiratory infection following exercise stress.

show abstract

“…5 The moderate intensity protocol was based on the protocols used in rats by other groups. 26,27 These protocols are well established in the literature, and their effects at the end of physical training has been previously described. 26,27 Considering respiratory mechanical function, we observed a significant decrease in Ers when comparing papain to saline groups.…”

Section: B Discussionmentioning

confidence: 99%

“…26,27 These protocols are well established in the literature, and their effects at the end of physical training has been previously described. 26,27 Considering respiratory mechanical function, we observed a significant decrease in Ers when comparing papain to saline groups. However, we did not find significant differences between papain groups that were submitted to different intensities of exercise.…”

Section: B Discussionmentioning

confidence: 99%

High intensity exercise training worsens alveolar destruction in pulmonary emphysema rats

Barnabé¹,

Lopes²,

Saraiva-Romanholo³

et al. 2014

Medical Express

View full text Add to dashboard Cite

OBJECTIVE: Investigation of standard intensities of physical exercise is important to better comprehend and develop rehabilitation programs for emphysema. We aimed to evaluate the effects of different intensities (moderate and high-intensity) of physical exercise on the development of a protease-induced (papain intratracheal instillation) emphysema in rats. METHODS: Male Wistar rats were randomly separated into five groups that received intratracheal instillation of papain solution or vehicle: (i) papain high intensity exercise, (ii) papain moderate exercise, (iii) saline high intensity exercise, (iv) saline sedentary and (v) papain sedentary. Forty days after intratracheal instillation, the exercise groups were submitted to an exercise-training protocol on a treadmill during 10 weeks, 5 days/week, at 0.9 km/h (Papain and saline high exercise), or at 0.6 km/h (papain moderate exercise). We measured respiratory system elastance and resistance, the collagen fiber lung parenchyma, and the pulmonary mean linear intercept. RESULTS: All animal groups that received papain instillation presented higher alveolar wall destruction compared to animals that received only saline solution. The papain high intensity exercise group presented higher values of mean linear intercept compared to emphysema groups that were trained at a moderate intensity or not submitted to exercise. CONCLUSION: High intensity exercise training worsened alveolar destruction in an experimental model of emphysema in rats when compared to moderate intensity exercise, or to no exercise.

show abstract

Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training

Cited by 43 publications

References 38 publications

Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury

Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury

Benefits of oat β-glucan on respiratory infection following exercise stress: role of lung macrophages

High intensity exercise training worsens alveolar destruction in pulmonary emphysema rats

Contact Info

Product

Resources

About