Abstract:Background Ectopic orofacial pain is frequently caused by tooth pulp inflammation. However, the detailed mechanism underlying such pain remains poorly understood.Methods To better understand this phenomenon, ectopic pain mechanism was studied in a rat model of mandibular first molar tooth pulp exposure (M1-TPE).Results One day after M1-TPE, obvious pulpal inflammation was observed in M1 pulp. The head withdrawal threshold to mechanical and heat stimulation of the tongue was significantly reduced in M1-TPE rats… Show more
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