Role of mean platelet volume (MPV) in diagnosing categories of thrombocytopenia

Khairkar, Pritam; More, Sarika; Pandey, Ashish; Pandey, Megha

doi:10.5958/2394-6792.2016.00112.5

Cited by 10 publications

(21 citation statements)

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“…11 The tests are simple, inexpensive and non invasive. 10,[12][13][14][15][16] MPV is an indicator of platelet size and is reported as a ratio of Plateletcrit to total platelet count in Hematology Analyser by different methods like Impedence, optical light scatter counting etc. 10,11,16,17 Normal MPV range for our study is 7.5 -10.5 fl 13,16 but differ in other due to many variables.…”

Section: Discussionmentioning

confidence: 99%

“…10,[12][13][14][15][16] MPV is an indicator of platelet size and is reported as a ratio of Plateletcrit to total platelet count in Hematology Analyser by different methods like Impedence, optical light scatter counting etc. 10,11,16,17 Normal MPV range for our study is 7.5 -10.5 fl 13,16 but differ in other due to many variables. 11,14,[16][17][18] In healthy individuals, MPV correlates inversely with platelet counts but the proportions differ in pathologic states.…”

Section: Discussionmentioning

confidence: 99%

“…In hypoproductive states only aged, small platelets remain in circulation. 10,[13][14][15][16][18][19][20][21] MPV correlates with platelet activation and recovery indicating the etiology of thrombocytopenia (hyperdestructive due to peripheral destruction of platelets with rapid marrow turnover or hypoproductive due to marrow suppression by virus) and impacts prognosis and treatment. 6,[11][12][13]15,16 Our study shows a predominance of younger aged and male patients in accordance with the other studies.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 Management dilemnas occur with severe thrombocytopenia due to risk of haemorrhage / bleeding leading to unwarranted, unsafe, excess and expensive transfusions. [8][9][10] A 'wait and watch' restrictive transfusion policy is beneficial. Laboratory tests like Platelet indices which aid in patient management have been investigated.…”

Section: Introductionmentioning

confidence: 99%

“…femtolitres (fl) is a predictor of platelet recovery, etiology of thrombocytopenia (hypoproliferative or rapidly responding bone marrow), worsening dengue and impacts therapy. 1,6,10…”

Section: Introductionmentioning

confidence: 99%

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Mean platelet volume: Has it the capacity to predict the concentration of Platelet counts in Dengue: A study

Joshi¹,

Sathyavathi²,

Gayathri³

et al. 2020

IJPO

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Dengue, endemic in India presents in mild to severe forms with or without bleeding. There is no specific treatment available till date hence severe dengue has to be recognized in early stages. Platelet counts are unreliable as they do not correlate with bleeding. Platelet indices have been studied for their utility as predictors of severity of the disease and aid in guide to transfusion therapy. Mean platelet volume is inexpensive and available with routine complete blood counts in hematology analyser. Its role as marker in diagnosis, prognosis and treatment of dengue has been investigated with platelet indices reports. To study MPV patterns, association with platelet counts and relevant laboratory parameters in dengue. The study was conducted over one month in the year 2016 in department of Hematology, Kempegowda Institute of Medical Sciences Hospital, Bengaluru. 100 serologically proven dengue cases were analysed with data collected from the records in the departments of Hematology and Microbiology against patient’s unique hospital identification number. There was a predominance of young male patients. The range for MPV was 8.7 – 13.2 (average 10.95) with 35% normal and 65% high MPV cases. There was 48% cases with moderately severe / severe thrombocytopenia. 32% with increased hematocrit, 35% with leucopenia, 54% with significant atypical lymphocytosis and 42% with antibody pattern. There was an increased number of high MPV seen in severe thrombocytopenia, increased hematocrit significant atypical lymphocytosis and antibody pattern whereas normal pattern was noted in leucopenia. High MPV is a useful predictor of severe dengue platelet recovery and may guide in transfusion therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…femtolitres (fl) is a predictor of platelet recovery, etiology of thrombocytopenia (hypoproliferative or rapidly responding bone marrow), worsening dengue and impacts therapy. 1,6,10…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mean platelet volume: Has it the capacity to predict the concentration of Platelet counts in Dengue: A study

Joshi¹,

Sathyavathi²,

Gayathri³

et al. 2020

IJPO

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Role of Platelet Indices as a Potential Marker for Malaria Severity

Bayleyegn

Asrie

Yalew

et al. 2021

Journal of Parasitology Research

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Purpose. Platelet parameter alteration such as platelet count and platelet indices are more common than in other blood cell lines due to diverse causative pathophysiological mechanisms in severe malaria infection. In malaria patients, no more studies evaluated platelet indices in relation to disease severity and prognosis. Therefore, this review assessed the current scientific knowledge on the potential role of platelet indices for the diagnostic marker of severe malaria infection. Results. Hence, after reviewing recent literatures, elevation of mean platelet volume and platelet distribution width in addition to decreased plateletcrit and platelet counts is the known potential risk factor associated with warning signs of severe malaria. Thus, thrombocytopenia < 150 × 10 9 / L , MPV ≥ 9.05 fL , and PDW ≥ 14.550 % as well as significantly higher P-LCR and decrease in PCT are shown significant sensitivity and specificity as they are used as diagnostic and prognostic values in severe malaria infection. Conclusion. Platelet indices are useful predictors of malaria severity. Immature platelet fraction (IPF%) is raised in the case of severe malaria, and it was significantly more useful than MPV. Advanced research will further investigate the platelet index abnormality associated with specific age and gender among specific malaria species.

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Study of Platelet Indices and Their Interpretation in Thrombocytopenia in a Tertiary Care Hospital

Mittal¹,

Munesh²,

Bali³

et al. 2021

jemds

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BACKGROUND Thrombocytopenia may either be due to increased destruction or impaired production of platelets. Platelet count alone is not enough to determine the mechanism of low platelets. Platelet indices like mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR) and platelet crit (PCT) can help determine the cause and we aimed at finding their role and function in cases of thrombocytopenia. METHODS An observational cross-sectional study of 155 patients with thrombocytopenia and 71 controls was done for a period of six months in SGT Hospital, Gurugram, to determine the mechanism behind the low platelet count with the help of these indices. RESULTS The mean values of the platelet indices (PDW, P-LCR and PCT) were found to be higher in accelerated destruction group (P < 0.05) in comparison to hypoproductive group, whereas, mean MPV values were higher in the former, but was not statistically significant. On comparison with the controls, both the groups of thrombocytopenia showed a statistically significant difference with P < 0.005 in all the four indices. Mean PCT values showed a highly significant difference between the two groups as well as with controls (P < 0.001) and also the relationship of PCT with severity of thrombocytopenia showed a direct relationship which was also significant (P < 0.001). CONCLUSIONS In distinguishing between the cause of thrombocytopenia i.e., hypoproductive or hyper destruction, platelet parameters play an important role. These platelet indices are easily available with the help of automated haematology analysers and can reduce the need for costly and invasive tests for evaluation of thrombocytopenia. KEY WORDS Mean Platelet Volume, Platelet crit, Platelet Distribution Width, Platelet Large Cell Ratio, Thrombocytopenia

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Role of mean platelet volume (MPV) in diagnosing categories of thrombocytopenia

Cited by 10 publications

References 0 publications

Mean platelet volume: Has it the capacity to predict the concentration of Platelet counts in Dengue: A study

Mean platelet volume: Has it the capacity to predict the concentration of Platelet counts in Dengue: A study

Role of Platelet Indices as a Potential Marker for Malaria Severity

Study of Platelet Indices and Their Interpretation in Thrombocytopenia in a Tertiary Care Hospital

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