Role of melatonin in reducing hypoxia-induced oxidative stress and morphological changes in the liver of male mice

El‐Sokkary, Gamal H.; Khidr, Bothaina M.; Younes, Hala A.

doi:10.1016/j.ejphar.2006.04.036

Cited by 23 publications

(15 citation statements)

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“…Melatonin possesses significant antioxidant capacity. Besides directly scavenging several reactive oxygen species (Hardeland et al, 1993), it has been show to prevent oxidative damage under a wide variety of experimental conditions (El-Sokkary, 2002;El-Sokkary et al, 2002, 2006. Melatonin is protective in a series of pathogenesis in which high production of free radicals is the primary cause of the disease .…”

Section: Introductionmentioning

confidence: 98%

Effect of chronic nicotine administration on the rat lung and liver: Beneficial role of melatonin

2007

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Section: Introductionmentioning

confidence: 98%

Effect of chronic nicotine administration on the rat lung and liver: Beneficial role of melatonin

2007

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“…Recently, El-Sokkary et al . indicated that hypoxia induced severe morphological changes and oxidative stress in the liver ( 40 ). In addition, angiotensin II has been shown to augment the aneurysms formation in apoE-KO mice, but not in wild-type mice ( 41 ).…”

Section: Fig 6 Immunochemistry and Percent Area Of 4-hydroxy-2-nonementioning

confidence: 99%

Angiotensin II Receptor Blocker Reduces Oxidative Stress and Attenuates Hypoxia-Induced Left Ventricular Remodeling in Apolipoprotein E-Knockout Mice

et al. 2007

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“…Melatonin was found to be protective in a number of pathological conditions including ischemia/reperfusion, inflammation, ionizing radiation and hypoxia. For example, it reduced the hypoxia‐induced injury in the liver [31], the ischemic‐reperfusion injury in skeletal muscle [32], heart [33] and brain [34]. Therefore, the aim of this study was to investigate whether melatonin could limit the IH‐induced hippocampal injury and inflammatory response with an increased expression of antioxidant enzymes.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia

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Poon³

et al. 2007

Journal of Pineal Research

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Obstructive sleep apnea (OSA) patients suffer from intermittent hypoxia (IH) and neuropsychologic impairments. Oxidative stress is involved in the pathogenesis of OSA, so the application of an antioxidant may be useful. We evaluated the hypothesis that melatonin would reduce IH-induced hippocampal injury via an increased expression of antioxidant enzymes. Adult Sprague-Dawley rats that had received a daily injection of melatonin or vehicle were exposed to IH for 8 hr/day for 7 or 14 days. The serum and hippocampus were harvested for the measurement of malondialdehyde (MDA). Apoptotic cell death was studied histologically in hippocampal sections. The mRNA expression of inflammatory mediators including tumor necrosis factor-alpha, inducible nitric oxide synthase, cyclooxygenase-2 and antioxidant enzymes including glutathione peroxidase, catalase and copper/zinc superoxide dismutase were examined in the hippocampus by RT-PCR. The results show significant increases in levels of serum and hippocampal MDA, apoptotic cell death and mRNA levels of inflammatory mediators in hypoxic rats when compared with the normoxic controls. Also, mRNA levels of the antioxidant enzymes were decreased in hypoxic animals. In the melatonin-treated hypoxic rats, serum MDA levels were comparable with those in normoxic control rats. Also, melatonin treatment significantly reduced hippocampal MDA levels and totally prevented apoptosis. Moreover, there were a decreased expression of the inflammatory mediators and an elevated expression of antioxidant enzymes in the melatonin injected rats when compared with vehicle-treated animals. These results indicate that melatonin mitigates oxidative stress and the pathogenesis of IH-induced hippocampal injury via its antioxidant and anti-inflammatory properties which includes stimulation of transcriptional regulation of antioxidant enzymes.

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Role of melatonin in reducing hypoxia-induced oxidative stress and morphological changes in the liver of male mice

Cited by 23 publications

References 43 publications

Effect of chronic nicotine administration on the rat lung and liver: Beneficial role of melatonin

Effect of chronic nicotine administration on the rat lung and liver: Beneficial role of melatonin

Angiotensin II Receptor Blocker Reduces Oxidative Stress and Attenuates Hypoxia-Induced Left Ventricular Remodeling in Apolipoprotein E-Knockout Mice

Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia

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