Role of melatonin on production and preservation of gametes and embryos: A brief review

Cruz, María; Leal, Cláudia Lima Verde; Cruz, Jurandir Ferreira da; Tan, Dun Xian; Reíter, Russel J.

doi:10.1016/j.anireprosci.2014.01.011

Cited by 74 publications

(59 citation statements)

References 124 publications

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“…The higher melatonin concentrations in the FF are maintained presumably by both active melatonin transport from the blood into the follicle and by ovarian synthesis [46]. The presence of serotonin, a precursor of melatonin, in granulosa cells and oocytes is consistent with local melatonin synthesis [64]. In the FF, melatonin acts by eliminating free radicals, stimulating antioxidant enzymes, and promoting sex steroid hormone production by granulosa cells [42].…”

Section: In the Folliclementioning

confidence: 89%

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Essential actions of melatonin in protecting the ovary from oxidative damage

Cruz¹,

Leal²,

Cruz

et al. 2014

Theriogenology

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Section: In the Folliclementioning

confidence: 89%

“…Melatonin appears to have varied functions at different stages of follicle development [64]. Although the information about the involvement of melatonin on preantral follicle development is limited, in a recent study, it was reported that melatonin in association with FSH promotes follicular growth of caprine preantral follicles [65].…”

Section: In the Folliclementioning

confidence: 99%

Essential actions of melatonin in protecting the ovary from oxidative damage

Cruz¹,

Leal²,

Cruz

et al. 2014

Theriogenology

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“…MT3 receptor is an enzyme which is located in the cytosol of some cells and is identified as quinone reductase 2, a phase II detoxifying enzyme . However, the main function and signal transduction cascade of this enzyme have not been identified …”

Section: Melatonin's Mechanism Of Actionmentioning

confidence: 99%

Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin

Hosseinzadeh

Kamrava

Joghataei

et al. 2016

Journal of Pineal Research

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292

184

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Osteoarthritis (OA) is a degenerative joint disease characterized by progressive erosion of articular cartilage. As chondrocytes are the only cell type forming the articular cartilage, their gradual loss is the main cause of OA. There is a substantial body of published research that suggests reactive oxygen species (ROS) are major causative factors for chondrocyte damage and OA development. Oxidative stress elicited by ROS is capable of oxidizing and subsequently disrupting cartilage homeostasis, promoting catabolism via induction of cell death and damaging numerous components of the joint. IL-1β and TNF-α are crucial inflammatory factors that play pivotal roles in the pathogenesis of OA. In this process, the mitochondria are the major source of ROS production in cells, suggesting a role of mitochondrial dysfunction in this type of arthritis. This may also be promoted by inflammatory cytokines such as IL-1β and TNF-α which contribute to chondrocyte death. In patients with OA, the expression of endoplasmic reticulum (ER) stress-associated molecules is positively correlated with cartilage degeneration. Melatonin and its metabolites are broadspectrum antioxidants and free radical scavengers which regulate a variety of molecular pathways such as inflammation, proliferation, apoptosis, and metastasis in different pathophysiological situations. Herein, we review the effects of melatonin on OA, focusing on its ability to regulate apoptotic processes and ER and mitochondrial activity. We also evaluate likely protective effects of melatonin on OA pathogenesis. K E Y W O R D Sapoptosis, endoplasmic reticulum, inflammation, melatonin, mitochondria, molecular actions, osteoarthritis, oxidative stress

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“…Our additional experiments revealed that the apoptotic index and reactive oxygen species (ROS) formation were higher in the 52 hr IVM group compared with the 44 hr IVM group. Increased ROS and apoptosis in embryos have been identified as being responsible for defective embryonic development (Cruz, Leal, Cruz, Tan, & Reiter, ; Takahashi et al, ; Yang et al, ). Thus, we speculated that the prolonged IVM (52 hr) strategy failed to improve the developmental capacity of poor‐quality oocytes because it induced more ROS and/or apoptosis.…”

Section: Introductionmentioning

confidence: 99%

“…Melatonin (N‐acetyl‐5‐methoxytryptamine), which is the principal secretory product of the pineal gland, controls important physiological processes, including sleep, circadian rhythms, metabolism, seasonal reproduction, and temperature regulation (Cruz et al, ; Lincoln, Clarke, Hut, & Hazlerigg, ; X. Tian et al, ). Melatonin also has free radical scavenging, anti‐oxidant, and anti‐apoptotic properties: it can directly scavenge toxic oxygen derivatives (Cruz et al, ); it can reduce ROS generation (Zhao et al, ); and it can stimulate the activity of anti‐oxidative enzymes (Li et al, ), including glutathione peroxidase (GSH) and SOD (superoxide dismutase) (Rodriguez et al, ). Melatonin has been successfully used to enhance the oocyte maturation and/or embryo development capacity in mice (X.…”

Section: Introductionmentioning

confidence: 99%

Melatonin supplementation during prolonged in vitro maturation improves the quality and development of poor‐quality porcine oocytes via anti‐oxidative and anti‐apoptotic effects

Lin

Lee

Kang

et al. 2018

Molecular Reproduction Devel

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Poor-quality oocytes (those with 1-2 layers of cumulus cells) typically possess low meiotic competence and development. Prolonging the duration of in vitro maturation (IVM; 52 hr) can enhance the maturation rate of poor-quality oocytes, but it does not improve subsequent embryonic development. This likely reflects the increased reactive oxygen species (ROS) production and apoptosis seen in these oocytes compared with the non-prolonged IVM (44 hr) group. Melatonin is a free radical scavenger, anti-oxidant and anti-apoptotic agent that reported to enhance the quality of embryos by inhibiting ROS generation and apoptosis. Therefore, we herein investigated whether melatonin combined with prolonged IVM (52 hr) could improve the quality and development of poor-quality oocytes. We supplemented IVM and/or in vitro culture (IVC) media with various concentrations (0, 10 , 10 , 10 M) of melatonin, and estimated parameters related to oocyte quality and development. The addition of melatonin (10 M) to a prolonged IVM system improved the oocyte quality and development compared with those of the melatonin-free poor-quality oocytes group, and that this was due to decreases in ROS generation, apoptosis, and DNA damage. When melatonin was added during both IVM (10 M) and IVC (10 M), we observed a cumulative positive influence on the embryonic development and quality; this treatment enhanced the expression level of Oct4 and decreased the levels of ROS, DNA damage, and apoptosis. Together, these findings suggest that the combination of melatonin plus prolonged IVM can improve the quality and development of poor-quality porcine oocytes via anti-oxidative and anti-apoptotic effects.

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Role of melatonin on production and preservation of gametes and embryos: A brief review

Cited by 74 publications

References 124 publications

Essential actions of melatonin in protecting the ovary from oxidative damage

Essential actions of melatonin in protecting the ovary from oxidative damage

Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin

Melatonin supplementation during prolonged in vitro maturation improves the quality and development of poor‐quality porcine oocytes via anti‐oxidative and anti‐apoptotic effects

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