Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation

Lin, Kailin; Song, Chao; Chen, Gang

doi:10.3389/fimmu.2015.00473

Cited by 12 publications

(7 citation statements)

References 61 publications

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“…Autoimmunity/inflammation disease: Tregs play an essential role in the prevention of autoimmune diseases and the maintenance of peripheral tolerance [ 1 , 63 ] in cancer therapy [ 15 , 64 ], transplantation tolerance [ 9 , 19 , 65 , 66 ], inflammatory bowel disease [ 67 ], allergy/asthma [ 68 , 69 ], liver disease [ 70 ], blood diseases [ 71 ], and dermatological diseases [ 72 ].…”

Section: Resultsmentioning

confidence: 99%

Global Regulatory T-Cell Research from 2000 to 2015: A Bibliometric Analysis

Yin

Dongying

2016

PLoS ONE

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We aimed to analyze the global scientific output of regulatory T-cell (Treg) research and built a model to qualitatively and quantitatively evaluate publications from 2000 to 2015. Data were obtained from the Web of Science Core Collection (WoSCC) of Thomson Reuters on January 1, 2016. The bibliometric method and Citespace III were used to analyze authors, journals, publication outputs, institutions, countries, research areas, research hotspots, and trends. In total, we identified 35,741 publications on Treg research from 2000 to 2015, and observed that the annual publication rate increased with time. The Journal of Immunology published the highest number of articles, the leading country was the USA, and the leading institute was Harvard University. Sakaguchi, Hori, Fontenot, and Wang were the top authors in Treg research. Immunology accounted for the highest number of publications, followed by oncology, experimental medicine, cell biology, and hematology. Keyword analysis indicated that autoimmunity, inflammation, cytokine, gene expression, foxp3, and immunotherapy were the research hotspots, whereas autoimmune inflammation, gene therapy, granzyme B, RORγt, and th17 were the frontiers of Treg research. This bibliometric analysis revealed that Treg-related studies are still research hotspots, and that Treg-related clinical therapies are the research frontiers; however, further study and collaborations are needed worldwide. Overall, our findings provide valuable information for the editors of immunology journals to identify new perspectives and shape future research directions.

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Section: Resultsmentioning

confidence: 99%

Global Regulatory T-Cell Research from 2000 to 2015: A Bibliometric Analysis

Yin

Dongying

2016

PLoS ONE

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“…Memory T cells may play a major role in mediating the acute cellular rejection. In retransplant patients, there could be two potential approaches for the generation of alloreactive memory T cells: (1) direct alloantigenic stimulation of naïve T cells during the course of the previous transplantation and (2) homeostatic proliferation in response to transient lymphopenia resulting from T-cell depletion therapy, which induces the proliferation and differentiation of naïve T cells into memory cells [18]. In contrast to naïve T cells, memory T cells have lower activation thresholds and are less dependent on costimulation signals [19], are more resistant to killing by T-cell depletion therapy and regulation by regulatory T cells (Treg) [20], and are less susceptible to conventional immunosuppressive agents [21].…”

Section: Discussionmentioning

confidence: 99%

Patterns of Early Rejection in Renal Retransplantation: A Single-Center Experience

Zhu¹,

Lin

et al. 2016

Journal of Immunology Research

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It has been reported that kidney retransplant patients had high rates of early acute rejection due to previous sensitization. In addition to the acute antibody-mediated rejection (ABMR) that has received widespread attention, the early acute T-cell-mediated rejection (TCMR) may be another important issue in renal retransplantation. In the current single-center retrospective study, we included 33 retransplant patients and 90 first transplant patients with similar protocols of induction and maintenance therapy. Analysis focused particularly on the incidence and patterns of early acute rejection episodes, as well as one-year graft and patient survival. Excellent short-term clinical outcomes were obtained in both groups, with one-year graft and patient survival rates of 93.9%/100% in the retransplant group and 92.2%/95.6% in the first transplant group. Impressively, with our strict immunological selection and desensitization criteria, the retransplant patients had a very low incidence of early acute ABMR (6.1%), which was similar to that in the first transplant patients (4.4%). However, a much higher rate of early acute TCMR was observed in the retransplant group than in the first transplant group (30.3% versus 5.6%, P < 0.001). Acute TCMR that develops early after retransplantation should be monitored in order to obtain better transplant outcomes.

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“…Patients on the waiting list for organ transplantation can become sensitised to HLA antigens due to pregnancies, blood transfusions and previous transplantations. Sensitisation is one of several factors that promote development of HLA-specific memory T cells, the major effectors of organ transplant rejection (Lin et al, 2015). Even in patients without previous exposure to alloantigens, alloreactive memory cells can be detected as a result of heterologous immunity Stranavova et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

ELISpot assay and prediction of organ transplant rejection

Girmanova

Hrubá

Viklický

et al. 2021

Int J Immunogenetics

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The ELISpot assay is a sensitive technique applied to assess cytokine-producing memory/effector T cells and human leukocyte antigens (HLA)-specific IgG-producing B cells.Besides the fact that the method is laborious and is difficult to standardise between laboratories, it may provide valuable information on the immune response of recipients before and after organ transplantation. In this article, we briefly review the recent literature and discuss the clinical significance of the ELISpot assay in predicting the risk and incidence of allograft rejection and survival.

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Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation

Cited by 12 publications

References 61 publications

Global Regulatory T-Cell Research from 2000 to 2015: A Bibliometric Analysis

Global Regulatory T-Cell Research from 2000 to 2015: A Bibliometric Analysis

Patterns of Early Rejection in Renal Retransplantation: A Single-Center Experience

ELISpot assay and prediction of organ transplant rejection

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