2017
DOI: 10.21608/ejh.2017.3695
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Role of Mesenchymal Stem Cells Versus their Conditioned Medium on Cisplatin-Induced Acute Kidney Injury in Albino Rat. A Histological and Immunohistochemical Study

Abstract: Introduction: Acute kidney injury (AKI) is a syndrome of rapidly declining renal function. Cisplatin nephrotoxicity is a major cause of AKI in about one third of patients under cisplatin treatment. Stem cell therapy have been suggested as a protective measure against cisplatin-induced AKI. The conditioned medium of the stem cells (serum-free culture medium) has been also found to minimize renal injury and might develop a new therapeutic strategy that avoids stem cells administration. Aim of the Study:This stud… Show more

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Cited by 9 publications
(10 citation statements)
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“…Group IV (CM treated group): Rats were injected with methyl mercuric chloride as in group II. Three hours later, rats were injected with single dose of the CM into caudal vein at a dose of 0.5 ml/ rat [21]. All rats were sacrificed after one week from commencement of experiment after ether inhalation.…”
mentioning
confidence: 99%
“…Group IV (CM treated group): Rats were injected with methyl mercuric chloride as in group II. Three hours later, rats were injected with single dose of the CM into caudal vein at a dose of 0.5 ml/ rat [21]. All rats were sacrificed after one week from commencement of experiment after ether inhalation.…”
mentioning
confidence: 99%
“…BMSCs (2 × 10 6 ) were cultured for 48 hr with 2 ml of FBS‐free DMEM. The conditioned medium was aspirated out and collected in the Eppendorf tube to be filtered through 0.20 μm sterile syringe filters (NY14831; Corning, Germany; Abd El Zaher et al, 2017).…”
Section: Methodsmentioning
confidence: 99%
“…The cells were injected in the rat's tail vein. The animals were killed 28 days after injection with the stem cells (Abd El Zaher et al, 2017). …”
Section: Methodsmentioning
confidence: 99%
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