Role of Metallodrugs in Medicinal Inorganic Chemistry

Kumar, Manish; Kumar, Gyanendra; Kant, Arun; Masram, Dhanraj T.

doi:10.1002/9781119640868.ch3

Cited by 4 publications

(3 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first metallodrugs used in therapy were arsenic-based antimicrobial and antiparasitic agents. In particular, melarsoprol, an arsenic-based drug, is still used against trypanosomiasis [ 1 ], but other metal-based drugs with similar properties have emerged and are now commercially available [ 1 , 50 ]. One example is ferrochloroquine, an antimalarial agent, which is now undergoing phase II clinical trials.…”

Section: History and Applications Of Metallodrugsmentioning

confidence: 99%

NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments

Santos

Monteiro

Gomes

et al. 2022

IJMS

View full text Add to dashboard Cite

After the serendipitous discovery of cisplatin, a platinum-based drug with chemotherapeutic effects, an incredible amount of research in the area of coordination chemistry has been produced. Other transition metal compounds were studied, and several new relevant metallodrugs have been synthetized in the past few years. This review is focused on coordination compounds with first-row transition metals, namely, copper, cobalt, nickel or manganese, or with zinc, which have potential or effective pharmacological properties. It is known that metal complexes, once bound to organic drugs, can enhance the drugs’ biological activities, such as anticancer, antimicrobial or anti-inflammatory ones. NSAIDs are a class of compounds with anti-inflammatory properties used to treat pain or fever. NSAIDs’ properties can be strongly improved when included in complexes using their compositional N and O donor atoms, which facilitate their coordination to metal ions. This review focuses on the research on this topic and on the promising or effective results that complexes of first-row transition metals and NSAIDs can exhibit.

show abstract

Section: History and Applications Of Metallodrugsmentioning

confidence: 99%

NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments

Santos

Monteiro

Gomes

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Long-term effects may be different, requiring dialysis, kidney transplant, or medication cocktails to support other systems in the body. 152 This means that a lower dose should be administered to avoid side effects; however, this leads to cancers rapidly developing resistance due to suboptimum therapeutic levels in comparison with cisplatin and the related drugs carboplatin, in which bidentate dicarboxylate ligands replace the more labile chlorides of cisplatin, and oxaliplatin, in which the stable 1,2-diaminocyclohexane ligand leads to more tolerable compounds. 153 This highlights the evidence that ligand design can help ensure the biocompatible metal complex for medicinal application.…”

Section: Toxicitymentioning

confidence: 99%

Metal Complexes as DNA Synthesis and/or Repair Inhibitors: Anticancer and Antimicrobial Agents

Ngoepe

Clayton

2021

Pharmaceutical Fronts

View full text Add to dashboard Cite

Medicinal inorganic chemistry involving the utilization of metal-based compounds as therapeutics has become a field showing distinct promise. DNA and RNA are ideal drug targets for therapeutic intervention in the case of various diseases, such as cancer and microbial infection. Metals play a vital role in medicine, with at least 10 metals known to be essential for human life and a further 46 nonessential metals having been involved in drug therapies and diagnosis. These metal-based complexes interact with DNA in various ways, and are often delivered as prodrugs which undergo activation in vivo. Metal complexes cause DNA crosslinking, leading to the inhibition of DNA synthesis and repair. In this review, the various interactions of metal complexes with DNA nucleic acids, as well as the underlying mechanism of action, were highlighted. Furthermore, we also discussed various tools used to investigate the interaction between metal complexes and the DNA. The tools included in vitro techniques such as spectroscopy and electrophoresis, and in silico studies such as protein docking and density-functional theory that are highlighted for preclinical development.

show abstract

“…They have been successfully used as anticancer, antimicrobial, antiviral, and anti-inflammatory drugs. Moreover, metal-based agents can be used as adjuvants in immunotherapy to elicit an immune response [14][15][16]. Metallodrugs can interact with DNA, which is the main target in various therapies, including anticancer treatments.…”

Section: Introductionmentioning

confidence: 99%

Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study

Spisz

Chylewska

Królicka

et al. 2021

IJMS

View full text Add to dashboard Cite

Antibiotic resistance is a global problem, and one promising solution to overcome this issue is using metallodrugs, which are drugs containing metal ions and ligands. These complexes are superior to free ligands in various characteristics including anticancer properties and mechanism of action. The pharmacological potential of metallodrugs can be modulated by the appropriate selection of ligands and metal ions. A good example of proper coordination is the combination of sulfonamides (sulfamerazine, sulfathiazole) with a ruthenium(III) ion. This work aimed to confirm that the activity of sulfonamides antibacterial drugs is initiated and/or stimulated by their coordination to an Ru(III) ion. The study determined the structure, electrochemical profile, CT-DNA affinity, and antimicrobial as well as anticancer properties of the synthesized complexes. The results proved that Ru(III) complexes exhibited better biological properties than the free ligands.

show abstract

Role of Metallodrugs in Medicinal Inorganic Chemistry

Cited by 4 publications

References 106 publications

NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments

NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments

Metal Complexes as DNA Synthesis and/or Repair Inhibitors: Anticancer and Antimicrobial Agents

Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study

Contact Info

Product

Resources

About