Role of Micro-RNA in Colorectal Cancer Screening

Rodríguez-Montes, José Antonio; Sánchez, Pablo Menéndez

doi:10.1016/j.cireng.2014.05.007

Cited by 11 publications

(10 citation statements)

References 26 publications

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“…In fact, several miRNAs, including miR-21, miR-10b and miR-125b, have been used as predictors of chemoresistance in cancers. [33][34][35] Herein, our observation that increased miR-15b expression is associated with chemotherapy resistance, and poor patient prognosis may provide surrogates to predict the chemotherapeutic sensitivity for lung adenocarcinoma.…”

Section: Discussionmentioning

confidence: 91%

“…MiR-15b modulated MDR1/P-glycoprotein expression in human ovarian cancer cells by targeting HIPK2 34 and downregulation of miR-15b might reverse multidrug resistance of esophageal squamous cell carcinoma through regulation of MDR1 and apoptosis. 35 Despite the oncogenic role of miR-15b has been implicated by previous studies, the role of miR-15b in lung cancer chemotherpy and molecular mechanisms are not known. Here, we identified PEBP4 as the functional target, through which miR-15b regulates metastasis and chemoresistance.…”

Section: Discussionmentioning

confidence: 98%

“…(d) Kaplan-Meier survival curve indicates that patients with high miR-15b expression have shorter overall survival than those with low miR-15b expression (log-rank test, Po0.01). miR-15b activity in human lung adenocarcinoma cells Z Zhao et al Phosphatidylethanolamine binding protein (PEBP) family, is widely expressed in normal human tissues, highlighting its role in various physiologic processes, [33][34][35] but is considered to be a metastasis suppressor in cancer, its loss or reduced expression being associated with malignancy and prognosis in many types of metastatic and aggressive cancers. [18][19][20]30 Recently, a study showed that snail, a mediator of the EMT, can inhibit PEBP4 transcription and negatively correlates with PEBP4 levels in tumors.…”

Section: Discussionmentioning

confidence: 99%

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miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells

et al. 2015

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MicroRNAs (miRNAs) have been identified as important posttranscriptional regulators involved in various biological and pathological processes of cells, but their association with tumor chemoresistance has not been fully understood. We detected miR-15b expression in two lung adenocarcinoma cell lines, A549 and A549/CDDP, and then investigated the effects of miR-15b on the metastasis and the chemosensitivity of cancer cells, using both gain- and loss-of-function studies. The correlation between miR-15b level and chemoresistance was further investigated in clinical lung adenocarcinoma specimens. miR-15b was significantly upregulated in cisplatin-resistant lung adenocarcinoma A549/CDDP cells compared with parental A549 cells. miR-15b regulates epithelial-mesenchymal transition (EMT) and cisplatin resistance in vitro and modulates response of lung adenocarcinoma cells to cisplatin in vivo. Further studies identified phosphatidylethanolamine-binding protein 4 (PEBP4) as a direct and functional target of miR-15b. Small-interfering RNA-mediated PEBP4 knockdown revealed similar effects as that of ectopic miR-15b expression, whereas overexpression of PEBP4 attenuated the function of miR-15b in lung adenocarcinoma cells. Increased miR-15b expression was also detected in tumor tissues sampled from lung adenocarcinoma patients treated with cisplatin-based chemotherapy and was proved to be correlated with low expression of PEBP4, decreased sensitivity to cisplatin and poor prognosis. Our results suggest that upregulation of miR-15b could suppress PEBP4 expression and in turn contribute to chemoresistance of lung adenocarcinoma cells to cisplatin.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells

et al. 2015

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“…KRK taraması için birçok ülke yaygın olarak GGK, rektosigmoidoskopi ve kolonoskopi kullansa da, kapsül endoskopi ve sanal kolonoskopi gibi kolonu anatomik olarak inceleyen yöntemler veya deneysel aşamada olan plazmada veya gaytada çeşitli DNA ve mikroRNA moleküllerinin araştırılmasına dayanan bazı testlerle ilgili yoğun çalışmalar yapılmaktadır (Tablo 2). 9,10,11,12 Bu testlerin hangisi ya da hangilerinin kullanılacağı ile ilgili standart bir öneri yoktur. Ülkeler kanser görülme sıklığı, tarama yapacak iş gücü, ülkenin ekonomik durumu gibi bazı faktörlere bağlı olarak farklı tarama stratejileri uygulayabilmektedir.…”

Section: Discussionunclassified

Colonoscopy Findings in Patients Who Have Positive Fecal Occult Blood Test for Colorectal Cancer Screening

Mayır¹,

Ensari²,

Durhan³

et al. 2018

TJCD

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Amaç: Kolorektal kanser tarama amaçlı yapılan gaytada gizli kan testinde pozitiflik saptanarak kolonoskopi yapılan hastalarda kolonoskopi yapılma oranı, kanser, polip ve diğer kolorektal hastalık oranlarını ortaya çıkarmak amaçlanmıştır. Yöntem: Çalışmaya alınan hastaların kolonoskopi sonuçları prospektif olarak kayıt altına alındı. Bulgular: Kolonoskopi planlanan ardışık 300 hastanın sadece 127'si (%42,3) kolonoskopiyi kabul etti ve yaptırdı. Hastaların 47'sinde (%37) kolonoskopi normal idi. Kırk (%31,5) hastada benign polip, 24 (%18,9) hastada divertiküler hastalık, 40 (%31,5) hastada hemoroid veya anal fissür izlendi. Polip saptanan ve polipektomi yapılan hastalarda histopatolojik inceleme sonucunda bir (%0,8) hastada hafif şiddette displazi ve bir (%0,8) hastada malign polip saptandı. Sonuç: Gaytada gizli kan pozitifliği saptanan hastalarda kolonoskopi yaptırma oranı ve malignite saptanma oranı çok düşük bulunmuştur. Hastaların kolonoskopinin gerekliliği konusunda bildirilmesi ve kolonoskopi yaptırılmaya teşvik edilmesi kolorektal tarama programlarının başarıya ulaşmasında faydalı olacaktır. Anahtar Kelimeler: Kolorektal kanser, tarama, kolonoskopi ABSTRACT ÖZAim: To determine the rate of colonoscopies performed in patients referred for colonoscopy due to positive fecal occult blood test in colorectal cancer screening, and the rates of cancer, polyps, and other colorectal diseases detected in those who underwent colonoscopy. Method: Colonoscopy results of the patients were recorded prospectively. Results: Of the 300 consecutive patients scheduled for colonoscopy, only 127 (42.3%) underwent the procedure. Normal colonoscopy findings were seen in 47 (37%) of the patients. Forty patients (31.5%) had benign polyps, 24 (18.9%) had diverticulosis, and 40 (31.5%) had hemorrhoids or anal fissures. One patient (0.8%) had mild dysplasia and one patient (0.8%) had malignant polyp in histopathologic examination of polypectomy specimen. Conclusion: The colonoscopy rate and the rate of detection of malignancy were very low in patients who had positive fecal occult blood test in the present study. Informing patients about the need for colonoscopy and encouraging them to have colonoscopy will be helpful for the success of colorectal screening programs.

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“…miRNAs are small, evolutionary conserved, single-stranded, noncoding RNA molecules (approximately 22 nucleotides in length) that bind target mRNA to regulate gene expression [23,24]. MicroRNAs are involved in various physiological and pathological functions, such as apoptosis, cell proliferation, and differentiation, which indicate their functionality in carcinogenesis as tumor suppressor genes or oncogenes [25]. Up-or downregulation of miRNA can influence the tumorigenic outcome depending on the role(s) of the target genes on vital signaling processes [26].…”

Section: Papillary Thyroid Cancer and Liquid Biopsymentioning

confidence: 99%

Liquid Biopsy in Patients with Thyroid Carcinoma

Fridrihsone¹,

Āboliņš²,

Vanags³

et al. 2019

Liquid Biopsy

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Thyroid cancer is a comparatively rare tumor, which affects 1-5% of women and approximately 2% of men, although it is the most common endocrine malignancy worldwide. Furthermore, the incidence of thyroid cancer has been increasing remarkably in the last decades. Currently, diagnosis of thyroid cancer mainly is based on cytological criteria. Although fine needle aspiration is a minimally invasive procedure, complications can occur. Correct diagnosis is mandatory to select patients for surgical intervention and to determine appropriate extent of operation. Overdiagnosis and the associated unnecessary surgery should be avoided as it might also lead to complications. Therefore it is important to practice noninvasive methods not only for early diagnosis of thyroid cancer but also for estimation of prognosis. Liquid biopsy is a promising, noninvasive method that can provide detection of circulating tumor cells (CTCs) as well as circulating nucleic acids such as DNA, mRNA, and microRNA in a blood sample. The aim of the chapter is to highlight the efficacy of liquid biopsy for diagnosis and prognosis of thyroid cancer. The chapter will represent a comprehensive literature review based on recent PubMed publications (mainly 2012-2018).

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Role of Micro-RNA in Colorectal Cancer Screening

Cited by 11 publications

References 26 publications

miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells

miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells

Colonoscopy Findings in Patients Who Have Positive Fecal Occult Blood Test for Colorectal Cancer Screening

Liquid Biopsy in Patients with Thyroid Carcinoma

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