Role of microbes in the pathogenesis of neuropsychiatric disorders

Goswami, Aranyak; Wendt, Frank R.; Pathak, Gita A; Tylee, Daniel S.; Angelis, Flavio De; Lillo, Antonella De; Polimanti, Renato

doi:10.1016/j.yfrne.2021.100917

Cited by 12 publications

(7 citation statements)

References 193 publications

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“…Increased levels of Borrelia -specific IgG antibodies strongly correlated with SARS-CoV-2 viral severity and the risk of hospitalization [ 349 ]. The human microbiota has been implicated in the development of a variety of mental illnesses, including Alzheimer’s disease, attention-deficit/hyperactivity disorder, anorexia nervosa, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and substance use disorders [ 350 ]. The human gut microbiome is recognized to have a significant impact upon both health and disease, as well as human metabolism, nutrition, physiology, and immune functioning.…”

Section: Resultsmentioning

confidence: 99%

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Microbes and Mental Illness: Past, Present, and Future

Bransfield,

Mao,

Greenberg

2023

Healthcare

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A review of the association between microbes and mental illness is performed, including the history, relevant definitions, infectious agents associated with mental illnesses, complex interactive infections, total load theory, pathophysiology, psychoimmunology, psychoneuroimmunology, clinical presentations, early-life infections, clinical assessment, and treatment. Perspectives on the etiology of mental illness have evolved from demonic possession toward multisystem biologically based models that include gene expression, environmental triggers, immune mediators, and infectious diseases. Microbes are associated with a number of mental disorders, including autism, schizophrenia, bipolar disorder, depressive disorders, and anxiety disorders, as well as suicidality and aggressive or violent behaviors. Specific microbes that have been associated or potentially associated with at least one of these conditions include Aspergillus, Babesia, Bartonella, Borna disease virus, Borrelia burgdorferi (Lyme disease), Candida, Chlamydia, coronaviruses (e.g., SARS-CoV-2), Cryptococcus neoformans, cytomegalovirus, enteroviruses, Epstein–Barr virus, hepatitis C, herpes simplex virus, human endogenous retroviruses, human immunodeficiency virus, human herpesvirus-6 (HHV-6), human T-cell lymphotropic virus type 1, influenza viruses, measles virus, Mycoplasma, Plasmodium, rubella virus, Group A Streptococcus (PANDAS), Taenia solium, Toxoplasma gondii, Treponema pallidum (syphilis), Trypanosoma, and West Nile virus. Recognition of the microbe and mental illness association with the development of greater interdisciplinary research, education, and treatment options may prevent and reduce mental illness morbidity, disability, and mortality.

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Section: Resultsmentioning

confidence: 99%

“…The human microbiome is not just located in the gut. It can also be located in other parts of the body [ 350 ]. Some of the human microbiota can be located deep in connective tissue, where they may be protected from the immune system and attempts at antibiotic treatment [ 352 , 353 , 354 ].…”

Section: Resultsmentioning

confidence: 99%

Microbes and Mental Illness: Past, Present, and Future

Bransfield,

Mao,

Greenberg

2023

Healthcare

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“…Notably, “amyloids” were another frequently used keyword in this research field and reflect a trend in research linking changes in gut microbiota strains with the progress of amyloid deposition [ 43 ]. Compared with healthy controls, AD patients display less microbial diversity of gut microbiota including deficits in fusobacteriaceae, firmicutes, and actinobacteria [ 44 , 45 , 46 ]. However, mechanisms underlying connections between gut microbiome and AD are still not clear.…”

Section: Discussionmentioning

confidence: 99%

The Microbiome–Gut–Brain Axis and Dementia: A Bibliometric Analysis

Sun

Feng

Zhang

et al. 2022

IJERPH

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Background: Associations between the microbiome–gut–brain axis and dementia have attracted considerable attention in research literature. This study examined the microbiome–gut–brain axis and dementia-related research from a bibliometric perspective. Methods: A search for original research and review articles on the microbiome–gut–brain axis and dementia was conducted in the Web of Science Core Collection (WOSCC) database. The R package “bibliometrix” was used to collect information on countries, institutions, authors, journals, and keywords. VOSviewer software was used to visualize the co-occurrence network of keywords. Results: Overall, 494 articles met the study inclusion criteria, with an average of 29.64 citations per article. Corresponding authors of published articles were mainly from China, the United States and Italy. Zhejiang University in China and Kyung Hee University in Korea were the most active institutions, while the Journal of Alzheimer’s Disease and Nutrients published the most articles in this field. Expected main search terms, “Parkinson disease” and “chain fatty-acids” were high-frequency keywords that indicate current and future research directions in this field. Conclusions: This bibliometric study helped researchers to identify the key topics and trends in the microbiome–gut–brain axis and dementia-related research. High-frequency keywords identified in this study reflect current trends and possible future directions in this field related to methodologies, mechanisms and populations of interest.

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“…Numerous studies have revealed that the intestinal microbiota regulates host physiological homeostasis and behavioral exhibition in response to stress and related neurological disorders via the microbiota–gut–brain (MGB) and microbiota–gut–immune (MGI) axes in humans and other mammals [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Stress has a major impact on gut physiological homeostasis, leading to increased intestinal permeability (gut dysbiosis), subsequently causing neuroinflammation [ 11 ] and affecting the clinical course of neuropsychiatric disorders and behavioral exhibition including aggression [ 12 , 13 , 14 , 15 , 16 ]. Gastrointestinal diseases such as inflammatory bowel disease and irritable bowel syndrome have been linked to psychological disorders [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Probiotic Bacillus subtilis on Injurious Behavior in Laying Hens

Jiang

Cheng

2022

Animals

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Intestinal microbiota functions such as an endocrine organ to regulate host physiological homeostasis and behavioral exhibition in stress responses via regulating the gut–brain axis in humans and other mammals. In humans, stress-induced dysbiosis of the gut microbiota leads to intestinal permeability, subsequently affecting the clinical course of neuropsychiatric disorders, increasing the frequency of aggression and related violent behaviors. Probiotics, as direct-fed microorganism, have been used as dietary supplements or functional foods to target gut microbiota (microbiome) for the prevention or therapeutic treatment of mental diseases including social stress-induced psychiatric disorders such as depression, anxiety, impulsivity, and schizophrenia. Similar function of the probiotics may present in laying hens due to the intestinal microbiota having a similar function between avian and mammals. In laying hens, some management practices such as hens reared in conventional cages or at a high stocking density may cause stress, leading to injurious behaviors such as aggressive pecking, severe feather pecking, and cannibalism, which is a critical issue facing the poultry industry due to negative effects on hen health and welfare with devastating economic consequences. We discuss the current development of using probiotic Bacillus subtilis to prevent or reduce injurious behavior in laying hens.

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Role of microbes in the pathogenesis of neuropsychiatric disorders

Cited by 12 publications

References 193 publications

Microbes and Mental Illness: Past, Present, and Future

Microbes and Mental Illness: Past, Present, and Future

The Microbiome–Gut–Brain Axis and Dementia: A Bibliometric Analysis

The Impact of Probiotic Bacillus subtilis on Injurious Behavior in Laying Hens

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