Role of micronutrients during peri-parturient period of dairy animals – a review

Keshri, Anchal; Bashir, Zahid; Kumari, Vandana; Prasad, Kotresh; Joysowal, Mamata; Singh, Man; Singh, Digvijay; Tarun, Anupama; Shukla, Smriti

doi:10.1080/09291016.2019.1613793

Cited by 8 publications

(7 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Maternal vitamin and mineral status has been suggested to affect hormonal regulatory pathways linking maternal metabolism with the fetoplacental unit [ 5 , 15 ]. Likewise, vitamins and minerals are required in biological processes such as energy metabolism, immune function, and gene expression [ 2 , 16 , 17 ]. Additionally, micronutrient-dependent enzymes that are involved with hormone synthesis and nutrient transport are present in the placenta [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the known effect of minerals on female reproductive traits and embryonic development [ 17 ], vitamin and mineral supplementation is still not widely adopted in cattle production [ 21 ]. Vitamins and minerals modulate the body’s energy homeostasis, and therefore, they are intricately related with the metabolism of carbohydrate, protein, and fat [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Vitamin and Mineral Supplementation and Rate of Maternal Weight Gain Affects Placental Expression of Energy Metabolism and Transport-Related Genes

Diniz

Reynolds

Borowicz

et al. 2021

Genes

View full text Add to dashboard Cite

Maternal nutrients are essential for proper fetal and placental development and function. However, the effects of vitamin and mineral supplementation under two rates of maternal weight gain on placental genome-wide gene expression have not been investigated so far. Furthermore, biological processes and pathways in the placenta that act in response to early maternal nutrition are yet to be elucidated. Herein, we examined the impact of maternal vitamin and mineral supplementation (from pre-breeding to day 83 post-breeding) and two rates of gain during the first 83 days of pregnancy on the gene expression of placental caruncles (CAR; maternal placenta) and cotyledons (COT; fetal placenta) of crossbred Angus beef heifers. We identified 267 unique differentially expressed genes (DEG). Among the DEGs from CAR, we identified ACAT2, SREBF2, and HMGCCS1 that underlie the cholesterol biosynthesis pathway. Furthermore, the transcription factors PAX2 and PAX8 were over-represented in biological processes related to kidney organogenesis. The DEGs from COT included SLC2A1, SLC2A3, SLC27A4, and INSIG1. Our over-representation analysis retrieved biological processes related to nutrient transport and ion homeostasis, whereas the pathways included insulin secretion, PPAR signaling, and biosynthesis of amino acids. Vitamin and mineral supplementation and rate of gain were associated with changes in gene expression, biological processes, and KEGG pathways in beef cattle placental tissues.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal Vitamin and Mineral Supplementation and Rate of Maternal Weight Gain Affects Placental Expression of Energy Metabolism and Transport-Related Genes

Diniz

Reynolds

Borowicz

et al. 2021

Genes

View full text Add to dashboard Cite

show abstract

“…The increase in their metabolic needs during this period is accompanied by an increase in the need for micronutrients, amino acids and energy, in which inadequate supply of these nutrients and metabolites makes animals more susceptible to a range of metabolic and infectious diseases. Therefore, nutrients and micronutrients play an important role in the pre‐to postpartum periods (Keshri et al., 2021 ). There is evidence that micronutrients are involved in functions such as the intracellular detoxification of free radicals, the synthesis of reproductive steroids and other hormones, carbohydrates and proteins and nucleic acid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

Barimanloo

Chalmeh

Pourjafar

et al. 2021

Veterinary Medicine & Sci

View full text Add to dashboard Cite

Background: Management and control of metabolic disorders in sheep around parturition is important. and various researchers have suggested different managerial solutions. Butaphosphan and cyanocobalamin are widely used for curing metabolic disorders resulting from poor nutrition, inadequate management or diseases.Objectives: It was hypothesised that butaphosphan and cyanocobalamin could improve the metabolism of ewes around parturition.Methods: Twenty-eight clinically healthy 3-year-old pregnant Afshari ewes from 21 days before parturition were enrolled into four equal groups: control (Ctrl), B+C1, B+C2 and B+C3. The Ctrl group only received intravenous normal saline and B+C1, B+C2 and B+C3 ewes, respectively, received an intravenous combination of 10% butaphosphan and 0.005% cyanocobalamin at 2, 4 and 6 ml/ewe, on Days 19-21, 10-12 and 1-3 before parturition. Blood samples were taken from all the ewes on Days 21, 12 and 3 before lambing at parturition day and on days 3, 12 and 21 after parturition.A body condition score of all the ewes was assessed at blood sampling days, and lambs born from the ewes were weighed at birth and every 2 weeks up to 3 months. Serum concentrations of glucose, cortisol, non-esterified fatty acids, beta-hydroxy butyric acid, triglyceride, cholesterol, high-, low-and very-low-density lipoproteins, aspartate aminotransferase and alanine aminotransferase were measured.Results: This drug combination decreased circulating glucose, cortisol, lipid profile and hepatic enzymes via dose-dependent manner, 6 ml of this drug compound/ewe was more potent than 4 and 2 ml/ewe. The lambs' weight from mothers receiving 6 ml of this combination was significantly higher than those of the others. Conclusions:It may be suggested that the intravenous administration of 6 ml/ewe of this combination for 3 consecutive days in three states before parturition had prophylactic effects on metabolic disorders of ewes and enhanced the lambs weight gain after birth.

show abstract

“…Firstly, research has shown that dairy cows do not need to be exogenously supplemented with B vitamin supplements, because the B vitamins in the diet and those synthesized by the ruminal microflora are sufficient in quantity. These attitudes have changed, especially due to metabolic changes in the calving period [ 4 , 5 ]. In this period, cows experience changes in the energy metabolism, metabolic stress, negative energy balance, insulin resistance, changes in lipid metabolism, reduced food intake and increased milk production [ 6 , 7 ], which directly or indirectly affect the production and availability of vitamins in the bodies of cows.…”

Section: Introductionmentioning

confidence: 99%

Niacin Status Indicators and Their Relationship with Metabolic Parameters in Dairy Cows during Early Lactation

Petrovic

Đoković

Cincović

et al. 2022

Animals

View full text Add to dashboard Cite

Previous experimental models on cows have examined the difference in the metabolic adaptation in cows after niacin administration, without identifying the most important mediators between niacin administration and its biological effects, namely active forms of niacin. All tissues in the body convert absorbed niacin into its main metabolically active form, the coenzyme nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). The aim of this study was to determine the influence of niacin administration in periparturient period on NAD, NADP and the NAD:NADP ratio and to determine relationship between these indicators of an active form of niacin with metabolic parameters in cow blood. The study included 90 healthy cows: 45 cows receiving niacin and 45 cows were negative control. The niacin group was treated with nicotinic acid for two weeks before, as well as two weeks after parturition. Nicotinic acid was applied per os with feed. In cows receiving niacin, there was a significantly higher concentration of NAD and NADP, but the NAD:NADP ratio did not differ compared with control. All three indicators were able to separate cows who received and who did not receive additional niacin. NAD and NADP are good indicators of the availability of niacin from additional sources. The NAD:NADP ratio is a good indicator of the biological effect of applied niacin on metabolites in cows due to its correlation with a number of metabolites: positive correlation with glucose, insulin, glucose to insulin ratio and the revised quantitative insulin sensitivity check index (RQUICKIBHB) of insulin resistance, triglycerides and cholesterol, and a negative correlation with nonesterified fatty acid (NEFA), beta hydroxybutyrate (BHB), gamma-glutamyltranspherase (GGT) and urea in cows receiving niacin. The same amount of added niacin in feed can produce different concentrations of NAD, NADP and NAD:NADP in the blood, and this was not related to their concentration before the addition of niacin. The change in the concentration of the active form of niacin (NAD, NADP and NAD:NADP) further correlates with the concentration of metabolic parameters, which indicates that the intensity of the biological effect of additional niacin can be accurately determined only if we know the concentrations of its active forms in blood. Under basal conditions (without additional niacin), active forms of niacin that already exist in the blood do not show significant correlations with metabolic parameters.

show abstract

Role of micronutrients during peri-parturient period of dairy animals – a review

Cited by 8 publications

References 44 publications

Maternal Vitamin and Mineral Supplementation and Rate of Maternal Weight Gain Affects Placental Expression of Energy Metabolism and Transport-Related Genes

Maternal Vitamin and Mineral Supplementation and Rate of Maternal Weight Gain Affects Placental Expression of Energy Metabolism and Transport-Related Genes

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

Niacin Status Indicators and Their Relationship with Metabolic Parameters in Dairy Cows during Early Lactation

Contact Info

Product

Resources

About