Role of microRNA and Oxidative Stress in Influenza A Virus Pathogenesis

Haque, Md. Mamunul; Murale, Dhiraj P.; Lee, Jung Hoon

doi:10.3390/ijms21238962

Cited by 19 publications

(15 citation statements)

References 49 publications

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“…It was found that varied miRNAs were involved in the innate immune response upon IAV infection in humans [ 140 ]. On the one hand, some miRNAs play a positive role, inducing an antiviral immune response and inhibiting IAV replication.…”

Section: Influenza Virusmentioning

confidence: 99%

“…miR-29c enhances the expression of A20 protein induced by IAV, inhibiting the activity of NF-κB and the expression of pro-inflammatory cytokines [ 144 ]. Previous reviews have well documented the multiple roles of miRNAs in the regulation of innate immunity upon IAV infection [ 140 , 145 ]. In addition to miRNAs, other noncoding RNAs such as long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) may also involve regulation of mRNAs in control of gene transcription.…”

Section: Influenza Virusmentioning

confidence: 99%

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Roles of RNA Sensors in Host Innate Response to Influenza Virus and Coronavirus Infections

Wang

Zheng

2022

IJMS

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Influenza virus and coronavirus are two important respiratory viruses, which often cause serious respiratory diseases in humans and animals after infection. In recent years, highly pathogenic avian influenza virus (HPAIV) and SARS-CoV-2 have become major pathogens causing respiratory diseases in humans. Thus, an in-depth understanding of the relationship between viral infection and host innate immunity is particularly important to the stipulation of effective control strategies. As the first line of defense against pathogens infection, innate immunity not only acts as a natural physiological barrier, but also eliminates pathogens through the production of interferon (IFN), the formation of inflammasomes, and the production of pro-inflammatory cytokines. In this process, the recognition of viral pathogen-associated molecular patterns (PAMPs) by host pattern recognition receptors (PRRs) is the initiation and the most important part of the innate immune response. In this review, we summarize the roles of RNA sensors in the host innate immune response to influenza virus and coronavirus infections in different species, with a particular focus on innate immune recognition of viral nucleic acids in host cells, which will help to develop an effective strategy for the control of respiratory infectious diseases.

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Section: Influenza Virusmentioning

confidence: 99%

Section: Influenza Virusmentioning

confidence: 99%

Roles of RNA Sensors in Host Innate Response to Influenza Virus and Coronavirus Infections

Wang

Zheng

2022

IJMS

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“…Compared to RSV, influenza may increase leukotriene concentrations by inducing the 5-LOX pathway ( 103 ). Similar to RSV, the miRNA expression profile of host cells is significantly changed by influenza ( 111 ). Among these miRNAs, let-7, miR-21, and miR-29 have connections with AA metabolism and miR-29 activates COX-2 through epigenetic changes during influenza A infection ( 104 ).…”

Section: Linkages Between Mirnas and Leukotrienes During Other Respiratory Virus Infectionsmentioning

confidence: 99%

miRNAs and Leukotrienes in Respiratory Syncytial Virus Infection

Fan

et al. 2021

Front. Pediatr.

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MicroRNAs (miRNAs) are small, non-coding RNAs that regulate posttranscription by binding to 3′-untranslated regions of target mRNAs. Recent functional studies have elucidated mechanisms that miRNAs regulate leukotriene synthesis by perturbing arachidonic acid metabolism. Both microarrays and high-throughput sequencing revealed distinct differential expression of miRNAs in children with respiratory syncytial virus (RSV) infection compared with healthy controls. Abnormal miRNA expression may contribute to higher leukotriene levels, which is associated with airway hyperreactivity. Targeting miRNAs may benefit to restore the homeostasis of inflammatory reaction and provide new strategies to alleviate airway hyperreactivity induced by RSV. In this article, we provide an overview of the current knowledge about miRNAs modulating leukotrienes through regulation of arachidonic acid metabolism with a special focus on miRNAs aberrantly expressed in children with RSV infection.

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“…Abnormal expression of microRNAs (miRNAs) is associated with the pathogenesis and pathological process of various human diseases [7]. It is proved that miRNA levels have a major influence on DM and its complications including DR. For example, miR-18a-5p affects DR and inhibits retinal angiogenesis by targeting fibroblast growth factor 1 and hypoxia-inducible factor 1-alpha [8].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-425-5p Is Involved in the Development of Diabetic Retinopathy and Regulates the Proliferation and Migration of Retinal Microvascular Endothelial Cells

et al. 2021

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Introduction: The objective of this article was to detect the expression pattern and clinical value of miR-425-5p in diabetic retinopathy (DR) patients and investigate its effect on the proliferation and migration of human retinal microvascular endothelial cells (HRMECs) in a high glucose (HG) state. Methods: The serum miR-425-5p level of the subjects was determined using quantitative real-time PCR. The diagnostic value of serum miR-425-5p was validated using the receiver operating characteristic curve. Pearson analysis detected the correlation between clinical indicators and microRNA. The influence of miR-425-5p on cell proliferation and migration under HG conditions was calculated by using Cell Counting Kit-8 and Transwell assay. Results: Serum miR-425-5p levels showed a gradual increasing trend in the healthy control group, the diabetic mellitus patients without DR, and DR patients. Moreover, the levels of miR-425-5p in proliferative DR (PDR) patients were elevated than that of non-PDR (NPDR) patients. Furthermore, upregulated miR-425-5p had a high diagnostic value for DR patients and can distinguish PDR patients from NPDR patients. The expression of miR-425-5p was significantly positively correlated with the fasting plasma glucose, glycosylated hemoglobin (HbA1C), homeostasis model assessment of insulin resistance, and disease course of the patients. Under HG conditions, overexpression of miR-425-5p promoted HRMEC proliferation and migration, while inhibition of miR-425-5p led to opposite results. Conclusion: Present research confirmed that serum miR-425-5p levels in DR are marked by elevation. High expression of miR-425-5p can be used as a feasible diagnostic biomarker for DR patients and can predict the development and severity of DR. Moreover, inhibiting the expression of miR-425-5p levels under the condition of hyperglycemia may be used as a valuable therapeutic strategy for preventing the pathogenesis of DR.

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Role of microRNA and Oxidative Stress in Influenza A Virus Pathogenesis

Cited by 19 publications

References 49 publications

Roles of RNA Sensors in Host Innate Response to Influenza Virus and Coronavirus Infections

Roles of RNA Sensors in Host Innate Response to Influenza Virus and Coronavirus Infections

miRNAs and Leukotrienes in Respiratory Syncytial Virus Infection

MicroRNA-425-5p Is Involved in the Development of Diabetic Retinopathy and Regulates the Proliferation and Migration of Retinal Microvascular Endothelial Cells

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