Role of miRNA Signatures in Health and Productivity of Livestock

Wara, Aamir Bashir; Chhotaray, Supriya; Shafi, Burhan Ud Din; Panda, Snehasmita; Tarang, Mitek; Yosuf, Saleem; Baba, Naseer Ahmad; Kumar, Amit

doi:10.20546/ijcmas.2019.804.079

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…Similarly, analysis of a CpG island in intron 10 of the imprinted KCNQ1 gene identified it as the origin of a non-coding transcript (KCNQ1OT1) that is required for imprinting of several genes within this domain ( Mancini-DiNardo et al, 2006 ). ncRNA regulation impacts on livestock productivity will not be discussed in this review as it has been adequately covered in the literature and in recent reviews ( Do and Ibeagha-Awemu, 2017 ; Wara et al, 2019 ; Kosinska-Selbi et al, 2020 ).…”

Section: Epigenetic Processes and Impacts On Gene Regulationmentioning

confidence: 99%

“…Continued technological advances have further promoted the implementation of genomic selection in livestock production ( Georges et al, 2019 ; Gurgul et al, 2019 ). Sequence analysis of livestock genomes uncovered the general molecular and regulatory mechanisms of the coding and non-coding genome underlying production and health traits, which have supported advances in trait improvement ( Kamath et al, 2016 ; Do et al, 2017a ; Wara et al, 2019 ). These factors still fall short of accounting for the optimal level of variation that is required to achieve continued improvements in livestock health and productivity.…”

Section: Introductionmentioning

confidence: 99%

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Impacts of Epigenetic Processes on the Health and Productivity of Livestock

Wang

Ibeagha‐Awemu

2021

Front. Genet.

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The dynamic changes in the epigenome resulting from the intricate interactions of genetic and environmental factors play crucial roles in individual growth and development. Numerous studies in plants, rodents, and humans have provided evidence of the regulatory roles of epigenetic processes in health and disease. There is increasing pressure to increase livestock production in light of increasing food needs of an expanding human population and environment challenges, but there is limited related epigenetic data on livestock to complement genomic information and support advances in improvement breeding and health management. This review examines the recent discoveries on epigenetic processes due to DNA methylation, histone modification, and chromatin remodeling and their impacts on health and production traits in farm animals, including bovine, swine, sheep, goat, and poultry species. Most of the reports focused on epigenome profiling at the genome-wide or specific genic regions in response to developmental processes, environmental stressors, nutrition, and disease pathogens. The bulk of available data mainly characterized the epigenetic markers in tissues/organs or in relation to traits and detection of epigenetic regulatory mechanisms underlying livestock phenotype diversity. However, available data is inadequate to support gainful exploitation of epigenetic processes for improved animal health and productivity management. Increased research effort, which is vital to elucidate how epigenetic mechanisms affect the health and productivity of livestock, is currently limited due to several factors including lack of adequate analytical tools. In this review, we (1) summarize available evidence of the impacts of epigenetic processes on livestock production and health traits, (2) discuss the application of epigenetics data in livestock production, and (3) present gaps in livestock epigenetics research. Knowledge of the epigenetic factors influencing livestock health and productivity is vital for the management and improvement of livestock productivity.

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Section: Epigenetic Processes and Impacts On Gene Regulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impacts of Epigenetic Processes on the Health and Productivity of Livestock

Wang

Ibeagha‐Awemu

2021

Front. Genet.

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“…The presence of miRNAs in the mammary gland cells of mice [35], humans [36], and cows and other farm animals [37][38][39] at different stages of development is now known, suggesting that they play an important role in the differential expression involved in mammary gland development and lactation. In addition, in recent years, with the development and expansion of the use of RNA sequencing technology for profiling the expression of miRNAs of different domestic mammals [40], more and more data on the role of miRNAs in various livestock species [41][42][43], the main source of human milk consumed en masse, have begun emerging. Thus, the most recent miRBase release contains 1025 mature miRNAs for cattle, 436 for goats, and 153 for sheep [44], while the RumimiR database, according to the latest data, contains 6808, 4011, and 9276 miRNAs, respectively [44].…”

Section: Locations Of Mirnas In the Mammary Glands Of Various Animalsmentioning

confidence: 99%

The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep

Dysin

Barkova

Pozovnikova

2021

ncRNA

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Milk is an integral and therefore complex structural element of mammalian nutrition. Therefore, it is simple to conclude that lactation, the process of producing milk, is as complex as the mammary gland, the organ responsible for this biochemical activity. Nutrition, genetics, epigenetics, disease pathogens, climatic conditions, and other environmental variables all impact breast productivity. In the last decade, the number of studies devoted to epigenetics has increased dramatically. Reports are increasingly describing the direct participation of microRNAs (miRNAs), small noncoding RNAs that regulate gene expression post-transcriptionally, in the regulation of mammary gland development and function. This paper presents a summary of the current state of knowledge about the roles of miRNAs in mammary gland development, health, and functions, particularly during lactation. The significance of miRNAs in signaling pathways, cellular proliferation, and the lipid metabolism in agricultural ruminants, which are crucial in light of their role in the nutrition of humans as consumers of dairy products, is discussed.

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Animal Wellness: The Power of Multiomics and Integrative Strategies

Choudhary,

Kumar B. V.,

Sekhar Mukhopadhyay

et al. 2024

Veterinary Medicine International

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The livestock industry faces significant challenges, with disease outbreaks being a particularly devastating issue. These diseases can disrupt the food supply chain and the livelihoods of those involved in the sector. To address this, there is a growing need to enhance the health and well‐being of livestock animals, ultimately improving their performance while minimizing their environmental impact. To tackle the considerable challenge posed by disease epidemics, multiomics approaches offer an excellent opportunity for scientists, breeders, and policymakers to gain a comprehensive understanding of animal biology, pathogens, and their genetic makeup. This understanding is crucial for enhancing the health of livestock animals. Multiomic approaches, including phenomics, genomics, epigenomics, metabolomics, proteomics, transcriptomics, microbiomics, and metaproteomics, are widely employed to assess and enhance animal health. High‐throughput phenotypic data collection allows for the measurement of various fitness traits, both discrete and continuous, which, when mathematically combined, define the overall health and resilience of animals, including their ability to withstand diseases. Omics methods are routinely used to identify genes involved in host‐pathogen interactions, assess fitness traits, and pinpoint animals with disease resistance. Genome‐wide association studies (GWAS) help identify the genetic factors associated with health status, heat stress tolerance, disease resistance, and other health‐related characteristics, including the estimation of breeding value. Furthermore, the interaction between hosts and pathogens, as observed through the assessment of host gut microbiota, plays a crucial role in shaping animal health and, consequently, their performance. Integrating and analyzing various heterogeneous datasets to gain deeper insights into biological systems is a challenging task that necessitates the use of innovative tools. Initiatives like MiBiOmics, which facilitate the visualization, analysis, integration, and exploration of multiomics data, are expected to improve prediction accuracy and identify robust biomarkers linked to animal health. In this review, we discuss the details of multiomics concerning the health and well‐being of livestock animals.

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Role of miRNA Signatures in Health and Productivity of Livestock

Cited by 4 publications

References 25 publications

Impacts of Epigenetic Processes on the Health and Productivity of Livestock

Impacts of Epigenetic Processes on the Health and Productivity of Livestock

The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep

Animal Wellness: The Power of Multiomics and Integrative Strategies

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