Role of N‐cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, Fumio; Hosokawa, Kentaro; Toyama, Hirofumi; Matsumoto, Yoshiko; Suda, Toshio

doi:10.1111/j.1749-6632.2012.06576.x

Cited by 53 publications

(38 citation statements)

References 33 publications

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“…The marrow is located within the bone, in which osteoblasts form a well-defined lining to which quiescent HSCs adhere (238,311,312). The association between these two cell types makes the distribution of osteoblasts a valid reference point for the recognition of HSC niches (18). Additionally, the possibility to ablate the niches and create empty structures that can be repopulated has provided the bases for prospective studies of HSCs.…”

Section: Cpc Nichesmentioning

confidence: 99%

Aging Effects on Cardiac Progenitor Cell Physiology

Rota

Goichberg

Anversa

et al. 2015

Comprehensive Physiology

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Cardiac aging has been confounded by the concept that the heart is a postmitotic organ characterized by a predetermined number of myocytes, which is established at birth and largely preserved throughout life until death of the organ and organism. Based on this premise, the age of cardiac cells should coincide with that of the organism; at any given time, the heart would be composed of a homogeneous population of myocytes of identical age. The discovery that stem cells reside in the heart and generate cardiac cell lineages has imposed a reconsideration of the mechanisms implicated in the manifestations of the aging myopathy. The progressive alterations of terminally differentiated myocytes, and vascular smooth muscle cells and endothelial cells may represent an epiphenomenon dictated by aging effects on cardiac progenitor cells (CPCs). Changes in the properties of CPCs with time may involve loss of self-renewing capacity, increased symmetric division with formation of daughter committed cells, partial depletion of the primitive pool, biased differentiation to the fibroblast fate, impaired ability to migrate, and forced entry into an irreversible quiescent state. Telomere shortening is a major variable of cellular senescence and organ aging, and support the notion that CPCs with critically shortened or dysfunctional telomeres contribute to myocardial aging and chronic heart failure. These defects constitute the critical variables that define the aging myopathy in humans. Importantly, a compartment of functionally competent human CPCs persists in the decompensated heart pointing to stem cell therapy as a novel form of treatment for the aging myopathy.

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Section: Cpc Nichesmentioning

confidence: 99%

Aging Effects on Cardiac Progenitor Cell Physiology

Rota

Goichberg

Anversa

et al. 2015

Comprehensive Physiology

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“…Therefore, the potential for new insights into the mobility of fetal liver can be achieved through monitoring the expression of N-cadherin. [23,24] Figure 1. An unfolded protein response produces protein kinase RNA-like endoplasmic reticulum kinase (PERK) stress, and the resultant oxidative stress will result in reactive oxygen species (ROS) induced damage.…”

Section: N-cadherinmentioning

confidence: 98%

The significance of cadherin for cell–cell interactions and cell adhesions on biomaterials

Shen

et al. 2015

Journal of Adhesion Science and Technology

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Cadherins are surface glycoproteins on plasma membranes and exist in many forms: T-cadherin, neuronal cadherin (N-cadherin), epithelial cadherin (E-cadherin), and vascular endothelial (VE-cadherin). Cadherins play critical roles in cell-cell interactions and are involved in multiple functions related to cell growth and proliferation. Findings from numerous reports have indicated that VE-cadherin regulates the remodeling, gating, and maturation of vascular vessels. The surface morphology of materials also impacts endothelial cell adhesion. This report is an overview of recent research on the effects of cadherins on cell-cell interactions, along with cell adhesions as examined on different materials. This summary will provide novel insights and approaches for research on cell-cell and cell-material interactions and illuminate some of the mechanisms of cell growth on different materials.

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“…64,65 Further work has indicated that key events may occur around sinusoidal perivascular niche that may involve endothelial cells, pericytes, CXCL abundant reticular cells, sinusoidal-megakaryocyte cells, neural crest cells, osteoblasts, osteoclasts, T cells, mesenchymal stem cells, macrophages, non-myelinating Schwann cells and preadipocytic fibroblasts. 66–72 A large number of putative regulators of the niche have also been described, including CXCL12, 73 E-selectin, 74 VEGFR 2, 75 N-cadherin 76 and osteopontin 77 and membrane bound steel factor. 78 Although these entities have various effects on hematopoietic stem cells their true role as niche maintenance factors is uncertain, except for that of membrane bound SCF.…”

Section: A Consideration Of Him or Nichesmentioning

confidence: 99%

A revisionist history of adult marrow stem cell biology or ‘they forgot about the discard’

Quesenberry

Goldberg

2017

Leukemia

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The adult marrow hematopoietic stem cell biology has largely been based on studies of highly purified stem cells. This is unfortunate because during the stem cell purification the great bulk of stem cells are discarded. These cells are actively proliferating. The final purified stem cell is dormant and not representative of the whole stem cell compartment. Thus, a large number of studies on the cellular characteristics, regulators and molecular details of stem cells have been carried on out of non-represented cells. Niche studies have largely pursued using these purified stem cells and these are largely un-interpretable. Other considerations include the distinction between baseline and transplant stem cells and the modulation of stem cell phenotype by extracellular vesicles, to cite a non-inclusive list. Work needs to proceed on characterizing the true stem cell population.

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Role of N‐cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Cited by 53 publications

References 33 publications

Aging Effects on Cardiac Progenitor Cell Physiology

Aging Effects on Cardiac Progenitor Cell Physiology

The significance of cadherin for cell–cell interactions and cell adhesions on biomaterials

A revisionist history of adult marrow stem cell biology or ‘they forgot about the discard’

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