Role of Nanobiotechnology in Drug Discovery, Development and Molecular Diagnostic

Dash, Deepak Kumar; Panik, Rajni Kant; Sahu, Anil Kumar; Tripathi, Vaibhav

doi:10.5772/intechopen.92796

Cited by 16 publications

(7 citation statements)

References 27 publications

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“…Nanobiotechnology is a boon to the field of medicine, which deals with the synthesis and application of a wide range of NPs for the treatment of diseases and targeted delivery of drugs (Patra et al, 2018;Dash et al, 2020). Synthesis of NPs using biological entities is always important due to their ease of production, eco-friendly approach, and bioavailability.…”

Section: Synthesis and Application Of Bioactive Nanoparticles From Ha...mentioning

confidence: 99%

Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications

et al. 2023

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Marine environments and salty inland ecosystems encompass various environmental conditions, such as extremes of temperature, salinity, pH, pressure, altitude, dry conditions, and nutrient scarcity. The extremely halophilic archaea (also called haloarchaea) are a group of microorganisms requiring high salt concentrations (2–6 M NaCl) for optimal growth. Haloarchaea have different metabolic adaptations to withstand these extreme conditions. Among the adaptations, several vesicles, granules, primary and secondary metabolites are produced that are highly significant in biotechnology, such as carotenoids, halocins, enzymes, and granules of polyhydroxyalkanoates (PHAs). Among halophilic enzymes, reductases play a significant role in the textile industry and the degradation of hydrocarbon compounds. Enzymes like dehydrogenases, glycosyl hydrolases, lipases, esterases, and proteases can also be used in several industrial procedures. More recently, several studies stated that carotenoids, gas vacuoles, and liposomes produced by haloarchaea have specific applications in medicine and pharmacy. Additionally, the production of biodegradable and biocompatible polymers by haloarchaea to store carbon makes them potent candidates to be used as cell factories in the industrial production of bioplastics. Furthermore, some haloarchaeal species can synthesize nanoparticles during heavy metal detoxification, thus shedding light on a new approach to producing nanoparticles on a large scale. Recent studies also highlight that exopolysaccharides from haloarchaea can bind the SARS-CoV-2 spike protein. This review explores the potential of haloarchaea in the industry and biotechnology as cellular factories to upscale the production of diverse bioactive compounds.

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Section: Synthesis and Application Of Bioactive Nanoparticles From Ha...mentioning

confidence: 99%

Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications

et al. 2023

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“…The last 20 years of research in bionanotechnology area has focused on developing NPs for in vivo applications, such as drug delivery, imaging, and theragnosis (Walia and Acharya 2016;Dash et al 2020). Multifunctional nano-constructs for tumor homing have been proposed by introducing targeting ligands, drugs, or biocompatible coatings onto inorganic and polymeric NPs (Saha et al 2012).…”

Section: Protein-polymer Nanoparticles (Biohnps)mentioning

confidence: 99%

Polymer-based nanoparticles: fabrication to applications—the many faces of DC8,9PC and albumin

Grasselli

Alonso

2021

Biophys Rev

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This review is directed to researchers interested in a new point of view with relevance to nano-biomedicine. The first part covers the uses and potential of diacetylene lipid, 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine (DC8,9PC) in facilitating biological target recognition. The second part concentrates on the use of albumin as a "soft" coating for nanoparticles. This review makes comment on how fabricated nanoparticles will assist with future human health applications.

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“…Plant midated synthesis of the nanoparticles like green technique has emerged rapidly during the last decade in a broad range of product domains 1 . Nanotechnology has been used in many of the essential requirements of daily life such as chemistry, biology, agriculture, physics, and medicine [2][3][4][5][6] . Today, due to the reduction of the size of many materials, such as their dimension have between 1 and 100 nm and resulted in unique properties such as their midget dimensions, shapes, flatten features and surface chemistry and their conductivity 7,8 and create a variety of research field in field of nanotechnology.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis and Evaluation of ZnO NPs and study the effect of Their toxic on Honey Bee (Apis mellifera)

Karim,

Abdullah,

Mohammad

2024

Baghdad Sci.J

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The research interest in nanomaterials preparation from natural products as a green method and their application in various fields applications, tremendous attention has been taken to the green composition of nanoparticles. ZnO can be considered one of the most widely used metal oxides for most requirements of daily used products. In this research ZnO NPs prepared by using Petroselinum crispum (parsley) extract and to make the first study of toxicological evaluation of ZnO NPs their effect aspects on Honey bees (Apis mellifera). ZnO NPs have been charactarized by using SEM, EDX, XRD, UV-Vis and FTIR Spectroscopy. The toxicological evaluation of ZnO NPs has been applied to a honey bee. The lethal ZnO concentration was obtained, and the LC50 range calculation values were changed during 288 hours of feeding to ZnO nanoparticles at different concentrations (25, 50, 250, 500 mg per 100 ml) and the obtained LC50 values changed from 275, decreasing to 162.55 for the research range times after every 24 hours of exposure feeding calculations. In addition, for the group treated with 500 mg of ZnO per 100 ml, higher mortality was observed compared to other concentrations as it increased more than all other items indicating the above concentrations but not with the control group. The ergonomic design for creating a honey bee shelter was first introduced and no similar investigations were found in the literature.

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Role of Nanobiotechnology in Drug Discovery, Development and Molecular Diagnostic

Cited by 16 publications

References 27 publications

Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications

Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications

Polymer-based nanoparticles: fabrication to applications—the many faces of DC8,9PC and albumin

Green Synthesis and Evaluation of ZnO NPs and study the effect of Their toxic on Honey Bee (Apis mellifera)

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