Role of natural juice in improving the ventilatory functions of smokers with chronic obstructive pulmonary disease

Saad, Amal; Mostafa, A.M.A.; Ibrahim, K.

doi:10.1080/13590840701211219

Cited by 1 publication

(2 citation statements)

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“… 29 Various factors, including smoking and air pollution, have been proved to be able to increase systemic oxidative stress in patients with COPD. 30 Overexposure to oxidants and /or decrease of antioxidants contribute to the development of COPD. One good example is smoking.…”

Section: Discussionmentioning

confidence: 99%

“…In the over 4000 identified constituents of cigarette smoke, a large number of oxidants, especially different free radicals were found, which might be responsible for the extra oxidative stress in COPD patients who smoke. 30 , 31 Antioxidant supplementation may improve the symptoms of COPD. 6 Vitamin C is a well-known antioxidant supplementation.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of Vitamin C Supplementation on Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review and Meta-Analysis

Lei¹,

Lu²,

Yu³

et al. 2022

COPD

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Background In recent years, the pleiotropic roles of antioxidants have drawn extensive attention in various diseases. Vitamin C is a well-known antioxidant, and it has been used to treat patients with chronic obstructive pulmonary disease (COPD). This systematic review and meta-analysis aim to demonstrate the impact of vitamin C supplementation in patients with COPD. Methods We searched PubMed, Embase, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI), SinoMed, Wanfang, and China Science and Technology Journal Database (cqvip.com) for eligible randomized controlled trials (RCTs) from their respective inception to May 18 th , 2021, by using the searching terms of COPD, vitamin C, and RCTs. A meta-analysis was performed to evaluate the effects of vitamin C on lung function, antioxidant levels, and nutritional conditions in COPD patients by using Review Manager (Version 5.4). Results Ten RCTs including 487 participants were eligible for our study. Meta-analysis results showed that vitamin C supplementation (≥400 mg/day) can significantly improve the forced expiratory volume in one second as a percentage (FEV1%) in COPD (SMD:1.08, 95% CI:0.03, 2.12, P =0.04). Moreover, vitamin C supplementation significantly improved the ratio of forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC) (WMD:0.66, 95% CI: 0.26, 1.06, P =0.001), vitamin C level in serum (SMD:0.63, 95% CI: 0.02, 1.24, P =0.04) and glutathione (GSH) level in serum (SMD:2.47, 95% CI: 1.06, 3.89, P =0.0006). While no statistically significant difference was observed in body mass index (BMI), fat-free mass index (FFMI), vitamin E level and superoxide dismutase (SOD) level in serum. Conclusion Vitamin C supplementation could increase the levels of antioxidation in serum (vitamin C and GSH) and improve lung function (FEV1% and FEV1/FVC), especially in patients treated with vitamin C supplementation greater than 400 mg/day. However, further prospective studies are needed to explore the role of vitamin C in improving nutritional status.

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Section: Discussionmentioning

confidence: 99%