Role of neurotrophin in the taste system following gustatory nerve injury

Meng, Lingbin; Jiang, Xin; Ji, Rui

doi:10.1007/s11011-014-9626-0

Cited by 5 publications

(4 citation statements)

References 87 publications

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“…As neurotrophins, such as brain-derived neurotrophic factor and nerve growth factor, are central to the development and sustenance of taste buds [10,29], DM-induced neuropathy might be a pivotal factor behind the taste disturbances [30]. These findings are consistent with similar research on taste bud degeneration in response to the removal of taste axons [31,32].…”

Section: Discussionsupporting

confidence: 84%

4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

Gaida,

Park,

Kim

2023

Applied Sciences

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Taste perception plays a crucial role in health and well-being but can be compromised by conditions such as diabetes mellitus (DM). This study delved into the efficacy of 4-hexylresorcinol (4-HR) in mitigating taste bud apoptosis, particularly in relation to DM-induced taste issues. Two primary rat groups were investigated: healthy rats and streptozotocin (STZ)-induced diabetic rats. Each group was further divided into control and experimental subsets, with the experimental group receiving 4-HR injections. A histological analysis of the circumvallate papillae (CVP) highlighted significant taste bud deterioration in the STZ subgroup, including loss of cellular content and a deviation from their typical morphology. Quantitatively, the control group had a mean of 39.6 ± 14.3 taste bud pores/mm2, contrasting with the 4HR, STZ, and STZ/4HR groups, which had means of 33.7 ± 14.2, 20.3 ± 6.1, and 28.0 ± 8.3, respectively. Additionally, a TUNEL assay and IHC staining for c-caspase-3 both identified increased apoptotic cells in the STZ subgroup, with the mean number of apoptotic cells per taste bud profile being notably higher in the STZ group at 3.2 ± 1.6. This study underscores the profound impact of diabetes on taste bud physiology and the potential therapeutic benefits of 4-HR. Further research is essential to delve deeper into its mechanisms and to ascertain optimal dosages, with the aim of enhancing the quality of life of diabetic patients.

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Section: Discussionsupporting

confidence: 84%

4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

Gaida,

Park,

Kim

2023

Applied Sciences

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“…This mechanism is reversed among healthy individuals, where vitamin D may stimulate TLR expression, but in preparation for pathogen exposure [ 43 ]. Another explanation can be due to the neuroprotective effects of vitamin D [ 44 ], which includes the regulation of the neurotrophins responsible for the development of the gustatory taste system [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial

et al. 2021

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Objective: Vitamin D deficiency has been associated with an increased risk of COVID-19 severity. This multi-center randomized clinical trial aims to determine the effects of 5000 IU versus 1000 IU daily oral vitamin D3 supplementation in the recovery of symptoms and other clinical parameters among mild to moderate COVID-19 patients with sub-optimal vitamin D status. Study Design and Setting: A total of 69 reverse transcriptase polymerase chain reaction (RT-PCR) SARS-CoV-2 positive adults who were hospitalized for mild to moderate COVID-19 disease were allocated to receive once daily for 2 weeks either 5000 IU oral vitamin D3 (n = 36, 21 males; 15 females) or 1000 IU oral vitamin D3 (standard control) (n = 33, 13 males; 20 females). Anthropometrics were measured and blood samples were taken pre- and post-supplementation. Fasting blood glucose, lipids, serum 25(OH)D, and inflammatory markers were measured. COVID-19 symptoms were noted on admission and monitored until full recovery. Results: Vitamin D supplementation for 2 weeks caused a significant increase in serum 25(OH)D levels in the 5000 IU group only (adjusted p = 0.003). Within-group comparisons also showed a significant decrease in BMI and IL-6 levels overtime in both groups (p-values < 0.05) but was not clinically significant in between-group comparisons. Kaplan–Meier survival analysis revealed that the 5000 IU group had a significantly shorter time to recovery (days) than the 1000 IU group in resolving cough, even after adjusting for age, sex, baseline BMI, and D-dimer (6.2 ± 0.8 versus 9.1 ± 0.8; p = 0.039), and ageusia (loss of taste) (11.4 ± 1.0 versus 16.9 ± 1.7; p = 0.035). Conclusion: A 5000 IU daily oral vitamin D3 supplementation for 2 weeks reduces the time to recovery for cough and gustatory sensory loss among patients with sub-optimal vitamin D status and mild to moderate COVID-19 symptoms. The use of 5000 IU vitamin D3 as an adjuvant therapy for COVID-19 patients with suboptimal vitamin D status, even for a short duration, is recommended.

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“…It has been revealed that BDNF is important in the developmental and mature taste system, by supporting survival of taste cells and geniculate ganglion neurons, and maintaining and guiding taste nerve innervations (19)(20)(21). These results demonstrated BDNF exhibits crucial effects in both of the central and peripheral nervous system.…”

Section: Bdnf and Trkb Receptormentioning

confidence: 93%

“…As a neurotrophin factor in the nervous system, BDNF regulates multiple processes including neuron differentiation, survival, dendritic pruning, patterning of innervation, synaptic function and plasticity (1,2). Our lab has demonstrated BDNF plays a vital role in the central and peripheral nervous system by regulating the developmental and mature taste system (19)(20)(21), and maintaining adult hippocampal neurogenesis (22,23). A recent clinical trial even showed elevation of BDNF levels by using CX1846 can correct age-related issues (96).…”

Section: Potential Side Effects Of Targeting Bdnf/trkb Pathway To Trementioning

confidence: 98%

Targeting the BDNF/TrkB pathway for the treatment of tumors (Review)

Meng

Liu

et al. 2018

Oncol Lett

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Neurotrophins are a family of growth factors that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4. Among them, BDNF is the most studied due to its high expression in the brain. Over the past two decades, BDNF and its receptor tropomyosin receptor kinase B (TrkB) have been reported to be upregulated in a wide range of tumors. This activated signal stimulates a series of downstream pathways, including phosphoinositide 3-kinase/protein kinase B, Ras-Raf-mitogen activated protein kinase kinase-extracellular signal-regulated kinases, the phospholipase-C-γ pathway and the transactivation of epidermal growth factor receptor. Activation of these signaling pathways induces oncogenic effects by increasing cancer cell growth, proliferation, survival, migration and epithelial to mesenchymal transition, and decreasing anoikis, relapse and chemotherapeutic sensitivity. The present review summarizes recent findings to discuss the role of BDNF in tumors, the underlying molecular mechanism, targeting Trk receptors for treatment of cancers and its potential risk.

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Role of neurotrophin in the taste system following gustatory nerve injury

Cited by 5 publications

References 87 publications

4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial

Targeting the BDNF/TrkB pathway for the treatment of tumors (Review)

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