Role of NF-κB in the pathogenesis of diabetes and its associated complications

Abstract

The nuclear factor-kappaB (NF-kappaB) family is comprised of DNA-binding protein factors that are required for the transcription of most proinflammatory molecules, including adhesion molecules, enzymes, cytokines, and chemokines. Studies performed in a variety of cell and animal based experimental systems suggest that NF-kappaB activation is a key event early in the pathobiology of diabetes. The purpose of this review is to summarize the current knowledge about the molecular biology of NF-kappaB and to review evidence that implicates NF-kappaB in the pathogenesis of diabetes and its associated complications.

Limonene Suppresses Lipopolysaccharide-Induced Production of Nitric Oxide, Prostaglandin E2, and Pro-inflammatory Cytokines in RAW 264.7 Macrophages

“…It is generally accepted that many intracellular signal pathways participate in the LPS-induced activation of macrophages and resultant production of pro-inflammatory cytokines/ mediators, and that nuclear factor NF -κB and mitogenactivated protein kinase MAPK pathways play key roles. NF-κB is one of the most ubiquitous transcription factors and coordinates the expression of pro-inflammatory enzymes and cytokines, making it a popular target for the development of potent inhibitors as novel anti-infl ammatory drugs [21][22][23][24] . Given the role of NF-κB in modulating the expression of infl ammatory mediators, it is possible that the inhibitory effects of D-limonene involve the inhibition of the NF-κB signalling pathway.…”

Alteration in Inflammation-related miR-146a Expression in NF-KB Signaling Pathway in Diabetic Rat Hippocampus

“…21 NF-KB plays a role in these systems processing via positive regulatory factors by TNF-α, IL-6, and IL-1ß, 22 which indicates the close relationship between neurological disorders and NF-KB activity in the expression of proinflammatory cytokines. 9 Therefore, NF-KB can play a role in some processes including synaptic plasticity, synaptic transmission, learning, and memory. 23 In the present study, increase in the amount of expression of NF-KB gene in diabetic group is significant compared with the control group, which could be a reason for increased apoptosis observed in the hippocampus of the diabetic rats.…”

“…7 Nuclear factor kappa B (NF-KB) is a transcription factor that is involved in the cellular response to the stimulations like proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukins (IL). 9 Activation of NF-KB is an important event in the gradual reduction of beta cells during diabetes where preventing this process provides a protection for beta cells against apoptosis inducted by cytokine. 10 Several studies have reported that diabetes, as an inflammatory disease, increases the level of NF-KB in most of the tissues in the body.…”

“…10 Several studies have reported that diabetes, as an inflammatory disease, increases the level of NF-KB in most of the tissues in the body. [7][8][9][10][11] Some studies have also indicated the appearance of inflammation in hippocampus among diabetic rats. 12 Hippocampus is an important part of the brain for memory performance and plays an important role in cognitive and emotional behaviors.…”

Kadar NF- Kβ Pankreas Tikus Model Type 2 Diabetes Mellitus dengan Pemberian Tepung Susu Sapi

“…System inflamasi ini diaktifkan oleh NF-K melalui regulasi cyclooxygenase, lipooxygenase, cytokine, chemokine dan proses adesi molekul [4]. Pada keadaan diabetes, kegiatan NF-K akan memicu disfungsi sel beta pancreas sehingga terjadi apoptosis yang progresif pada sel tersebut [5].…”