Role of nicotine on cognitive and behavioral deficits in sepsis-surviving rats

Leite, Franco Batista; Prediger, Rui Daniel; Silva, Mônica V.; Sousa, João Batista de; Carneiro, Fabiana Pirani; Gasbarri, Antonella; Tomaz, Carlos; Queiróz, Amadeu José Rodrigues; Martins, Natália T.; Ferreira, Vânia Maria Moraes

doi:10.1016/j.brainres.2013.02.036

Cited by 12 publications

(13 citation statements)

References 45 publications

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“…The animals were subjected to Caecal ligation and perforation (CLP) as previously described . Briefly, rats were anaesthetized with a mixture of ketamine (80 mg/kg) and xylazine (10 mg/kg), given intraperitoneally.…”

Section: Methodsmentioning

confidence: 99%

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Effects of Caffeine on Behavioural and Cognitive Deficits in Rats

Assis

Soares

Sousa

et al. 2018

Basic Clin Pharma Tox

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There are many studies that have sought to find drug therapies to prevent harm arising from sepsis. Such studies have represented a progress in the support to septic patients and also in the development of new pharmacological alternatives. Our interest was to investigate the caffeine effect on sepsis behavioural and memory impairments. Male rats were anaesthetized and the surgery was made to allow exposure of the caecum, which was then squeezed to extrude a small amount of faeces from the perforation site, which was later placed back into the peritoneal cavity. This procedure, which served to generate experimental sepsis, is herein referred to as ceccum ligation and perforation (CLP). The caffeine (10 mg/kg) was administered by gavage route, once daily, during 7 or 14 consecutive days to investigate the effects of acute or subchronic caffeine treatment on long-term behavioural and cognitive deficits induced by CLP. On the last day, 1 hr after caffeine administration, the animals were submitted to open-field, elevated plus maze (EPM), forced swimming and step-down inhibitory avoidance tests. The results showed that caffeine increased the percentage of open arm entries and open arm time in the EPM test, and reduced the immobility time when compared to the sham-operated group. The caffeine also increased the latency in the inhibitory avoidance test platform. Our results demonstrated that the caffeine improved behavioural changes and improved the neurocognitive deficits of sepsis-surviving animals. It is possible that blockage of the adenosine receptors may be responsible for the results here observed.

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Section: Methodsmentioning

confidence: 99%

“…The behavioural tests were conducted in independent groups of animals by an experienced experimenter who was unaware of the experimental group of the animals tested. After each trial, the apparatus was cleaned with ethanol solution (10% v/v) and dried with paper towels to avoid odour impregnation .…”

Section: Methodsmentioning

confidence: 99%

Effects of Caffeine on Behavioural and Cognitive Deficits in Rats

Assis

Soares

Sousa

et al. 2018

Basic Clin Pharma Tox

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“…Leite et al (2013) observed that repeated nicotine administration does not alter the survival rate in rats subjected to caecal ligation and puncture and they provide new evidence that nicotine can improve longlasting memory impairment and anxiogenic-like responses in sepsis-surviving animals. Tuon et al (2007), in turn, demonstrated in sepsis-surviving rats, a significant increase in the immobility time as compared to the shamoperated rats.…”

Section: Discussionmentioning

confidence: 81%

“…every 12 h for 3 days. They were kept in groups of 5 animals per cage with free access to food and water, according to the procedure performed elsewhere (Leite et al, 2013).…”

Section: Caecal Ligation and Perforation Surgerymentioning

confidence: 99%

“…Nowadays, several studies are conducted to evaluate the damage to the brain during sepsis and its behavioural consequences, especially involving cognitive and mood impairments present in sepsis survivors (Comim et al, 2016;Leite et al, 2013;Mazeraud et al, 2016;Tauber et al, 2017). The polymicrobial sepsis induced in rats by caecal ligation and perforation (CLP) experimental models are important because they reproduce human sepsis consequences (Leite et al, 2013), which is clinically relevant for elucidating new therapy alternatives for this health problem (Hutchins et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Effects of lemon balm (Melissa officinalis) on behavioral deficits and memory impairment of rats surviving sepsis

Filho¹,

Silveira²,

Soares³

et al. 2017

J. Med. Plants Res.

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Sepsis has become one of the most frequent causes of mortality in intensive care centres. So far, there is no effective pharmacotherapy that can prevent or improve the neurological consequences and enhance survival. The goal of this study is to investigate the neuroprotective effect of lemon balm (Melissa officinalis) on behavioural dysfunctions produced in sepsis-surviving rats. Adult male rats were subjected to caecal ligation and puncture and the control animals were submitted to the sham operation. Lemon balm ethanolic extract or saline, given orally, was administered for one week after surgery procedures. Locomotion, anxiety, depressive behaviour and memory were investigated. In the elevated plus-maze (EPM), the percentage of open arm entries and open arm time was very significant in the animals treated with lemon balm extract, similar to the diazepam response in sham-operated and sepsis-surviving rats. Locomotion in open field tests and the enclosed arm entries in the EPM were not significantly altered by treatments. In the forced swimming (FS) test, the extract was effective at reducing the immobility time as that demonstrated by fluoxetine. In the step-down inhibitory avoidance test, the extract eased the effects on memory of sepsis-surviving animals. Collectively, these results demonstrate that lemon balm ethanolic extract could be used for the prevention of cognitive and moodrelated deficits that may be associated with sepsis sequelae.

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Post-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment

Li,

Zhang,

et al. 2024

Neurol Sci

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Post-sepsis psychiatric disorder, encompassing anxiety, depression, post-traumatic stress disorder and delirium, is a highly prevalent complication secondary to sepsis, resulting in a marked increase in long-term mortality among affected patients. Regrettably, psychiatric impairment associated with sepsis is frequently disregarded by clinicians. This review aims to summarize recent advancements in the understanding of the pathophysiology, prevention, and treatment of post-sepsis mental disorder, including coronavirus disease 2019-related psychiatric impairment. The pathophysiology of post-sepsis psychiatric disorder is complex and is known to involve blood–brain barrier disruption, overactivation of the hypothalamic–pituitary–adrenal axis, neuroinflammation, oxidative stress, neurotransmitter dysfunction, programmed cell death, and impaired neuroplasticity. No unified diagnostic criteria for this disorder are currently available; however, screening scales are often applied in its assessment. Modifiable risk factors for psychiatric impairment post-sepsis include the number of experienced traumatic memories, the length of ICU stay, level of albumin, the use of vasopressors or inotropes, daily activity function after sepsis, and the cumulative dose of dobutamine. To contribute to the prevention of post-sepsis psychiatric disorder, it may be beneficial to implement targeted interventions for these modifiable risk factors. Specific therapies for this condition remain scarce. Nevertheless, non-pharmacological approaches, such as comprehensive nursing care, may provide a promising avenue for treating psychiatric disorder following sepsis. In addition, although several therapeutic drugs have shown preliminary efficacy in animal models, further confirmation of their potential is required through follow-up clinical studies.

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Role of nicotine on cognitive and behavioral deficits in sepsis-surviving rats

Cited by 12 publications

References 45 publications

Effects of Caffeine on Behavioural and Cognitive Deficits in Rats

Effects of Caffeine on Behavioural and Cognitive Deficits in Rats

Effects of lemon balm (Melissa officinalis) on behavioral deficits and memory impairment of rats surviving sepsis

Post-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment

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