Role of nitric oxide and protein kinase C in the tachyphylaxis to vasopressin in rat aortic rings

Hamel, Christine; Millette, Esther; Lamontagne, Daniel

doi:10.1016/j.lfs.2004.12.039

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…Our results reveal that AVP provokes a slow-onset, long-lasting in vitro contraction persisting for up to 2 h. Today, V 1a is established as the subtype of AVP receptor involved in vascular contraction [10] and it is this receptor that displays rapid tachyphylaxis [13]. Hence, the desensitization of IMA towards AVP noted in the present study indirectly indicates that V 1a is the receptor involved in the AVP response.…”

Section: Discussionsupporting

confidence: 66%

Plasma levels and vascular effects of vasopressin in patients undergoing coronary artery bypass grafting☆

Novella

Martı́nez

Pagán

et al. 2007

European Journal of Cardio-Thoracic Surgery

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Section: Discussionsupporting

confidence: 66%

Plasma levels and vascular effects of vasopressin in patients undergoing coronary artery bypass grafting☆

Novella

Martı́nez

Pagán

et al. 2007

European Journal of Cardio-Thoracic Surgery

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“…Additionally, vasopressin demonstrated tachyphylaxis in control and denuded aortic rings upon subsequent administration of vasopressin. [10] Therefore, we determined the effects of a bolus dose of vasopressin (100nM) on separate OA preparations as well as two vasopressin concentration response curves (100pM to 1μM; 25mins apart) in additional OA preparations. Bolus dose of vasopressin elicited almost identical and statistically different responses between segments (distal segment E max : 61.4 ± 2.3% T K ; and proximal segment E max : 25.8 ± 1.02% T K, n = 5 for both; Supplementary Table 1).…”

Section: Resultsmentioning

confidence: 99%

Vasopressin-Induced Constriction of the Isolated Rat Occipital Artery is Segment Dependent

Chelko

Schmiedt²,

Lewis³

et al. 2013

J Vasc Res

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Background: Circulating factors delivered to the nodose ganglion (NG) by the occipital artery (OA) have been shown to affect vagal afferent activity, and thus the contractile state of the OA may influence blood flow to the NG. Methods: OA were isolated and bisected into proximal and distal segments relative to the external carotid artery. Results: Bisection highlighted stark differences between maximal contractile responses and OA sensitivity. Specifically, maximum responses to vasopressin and the V₁ receptor agonist were significantly higher in distal than proximal segments. Distal segments were significantly more sensitive to 5-hydroxytryptamine (5-HT) and the 5-HT₂ receptor agonist than proximal segments. Angiotensin II (AT)₂, V₂ and 5-HT_1B/1D receptor agonists did not elicit vascular responses. Additionally, AT₁ receptor agonists elicited mild, yet not significantly different maximal responses between segments. Conclusion: The results of this study are consistent with contractile properties of rat OA being mediated via AT₁, V₁ and 5-HT₂ receptors and dependent upon the OA segment. Furthermore, vasopressin-induced constriction of the OA, regardless of a bolus dose or a first and second concentration-response curve, retained this unique segmental difference. We hypothesize that these segmental differences may be important in the regulation of blood flow through the OA in health and disease.

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“…In Vivo Rat Lung Vascular Response to Vasoconstrictors 9 Tachyphylaxis to vasopressin through V1a receptors is well known in the arteries of humans [33,34] and rats [35,36].…”

Section: Experimental Lung Researchmentioning

confidence: 99%

Systemic vasoconstriction modulates the responses of pulmonary vasculature and airway to vasoconstrictors in anesthetized rats

Wang

Shibamoto

Kuda

et al. 2015

Experimental Lung Research

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Airway constriction is induced by U46619, and pulmonary vasoconstriction is induced strongly by U46619 and ET-1, and weakly by ANG II and phenylephrine, but not by vasopressin in anesthetized rats. ANG II, vasopressin and phenylephrine exert indirectly a transient pulmonary vasodilatory action due to pulmonary congestion evoked by strong systemic vasoconstriction, which may account for weak pulmonary pressor responses to these agents.

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Role of nitric oxide and protein kinase C in the tachyphylaxis to vasopressin in rat aortic rings

Cited by 9 publications

References 28 publications

Plasma levels and vascular effects of vasopressin in patients undergoing coronary artery bypass grafting☆

Plasma levels and vascular effects of vasopressin in patients undergoing coronary artery bypass grafting☆

Vasopressin-Induced Constriction of the Isolated Rat Occipital Artery is Segment Dependent

Systemic vasoconstriction modulates the responses of pulmonary vasculature and airway to vasoconstrictors in anesthetized rats

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