Role of Nitric Oxide in the Onset of Facial Nerve Palsy by HSV-1 Infection

Hato, Naohito; Kohno, Hiromasa; Yamada, Hiroyuki; Takahashi, Hirotaka; Gyo, Kiyofumi

doi:10.1001/jamaoto.2013.5542

Cited by 11 publications

(10 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This contention is supported by a previous study that showed the role of nitric oxide in HSV-1-related facial nerve paralysis in mice as well as prevention of facial paralysis by edaravone, a free radical scavenger. 28 The thiol/disulphide homeostasis seems impaired and may be used as an oxidative metabolism marker in Bell's palsy.…”

Section: Discussionmentioning

confidence: 99%

Thiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker

Babademez

Gül²,

Kale

et al. 2016

Clinical Otolaryngology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Thiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker

Babademez

Gül²,

Kale

et al. 2016

Clinical Otolaryngology

View full text Add to dashboard Cite

show abstract

“…The authors show the association of oxidative stress, peroxidation reactions and other changes in the elements of both central and peripheral nerve systems with the pathogenesis of HSV‐I (Valyi‐Nagy and Dermody, ; Schachtele et al, ; Hu et al, ; Hato et al, ).…”

Section: Discussionmentioning

confidence: 99%

Nerve Regeneration in Conditions of HSV‐Infection and an Antiviral Drug Influence

Gumenyuk

Рыбалко

Ryzha

et al. 2018

The Anatomical Record

View full text Add to dashboard Cite

Herpes simplex virus type I (HSV-I) is a latent neuroinfection which can cause focal brain lesion. The role of HSV-infection in nerve regeneration has not been studied so far. The aim of the work was to study sciatic nerve regeneration in the presence of HSV-infection and the influence of an antiviral drug. BALB/c line mice were divided into five groups. Group 1 animals were infected with HSV-I. After resolution of neuroinfection manifestations the sciatic nerve of these animals was crushed. Group 2 mice were administered acyclovir following the same procedures. Groups 3-5 mice served as controls. Thirty days after the operation distal nerve stumps and m.gastrocnemius were studied morphologically and biochemically. Ultrastructural organization of the sciatic nerve in control animals remained intact. Morphometric parameters of the nerves from the experimental groups have not reach control values. However, in the group 1 diameter of nerve fibers was significantly smaller than in the group 2. Both nerve regeneration and m.gastrocnemius reinnervation were confirmed. The muscle hypotrophy was found in groups 1, 2, and 3 (the muscle fibers diameter decreased). Metabolic changes in the muscles of the infected animals (groups 1 and 2) were more pronounced than in control groups 3 and 4. The levels of TBA-active products, conjugated dienes, carbonyl and SH-groups were reduced in m.gastrocnemius of the experimental groups, however no significant difference associated with acyclovir administration was found. HSV-infection is not limited to the local neurodegenerative changes in the CNS but affects regeneration of the injured sciatic nerve. Anat Rec, 301:1734-1744, 2018. © 2018 Wiley Periodicals, Inc.

show abstract

“…Causes of unilateral peripheral facial nerve paralysis are various and include idiopathic, viral infection, vascular, autoimmune reactions, traumatic, surgical procedures and neoplastic [11,12]. Herpes viruses seemed to be the most possible infective agent [5,6]. Lower motor neurone (LMN) facial palsy is characterized by unilateral paralysis of all muscles of facial expression for both voluntary and emotional responses.…”

Section: Discussionmentioning

confidence: 99%

“…Corticosteroids have long been used in Bell's palsy because of their powerful anti-inflammatory effect, and have been proven to be an effective treatment. Studies showed evidence for the presence of herpes simplex virus in some cases of bell's palsy [5,6], thus anti-viral agents were applied in some cases. Approximately 70% of all patients recover completely, and a higher percentage of improvement is achieved if corticosteroid therapy is prescribed [14,15].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Recovery in 61-Year-Old Male After Bell’s Palsy: A Case Report

Heidari¹

2017

Ann Clin Lab Res

View full text Add to dashboard Cite

Peripheral facial nerve palsy is the most common cranial nerve motor neuropathy. In majority of the cases, the cause is idiopathic and improvement of facial muscle function begins within first 3 weeks after onset of disease. This report presents a case of 61-year-old male patient who recourse to the emergency department with facial pain and asymmetry followed by peripheral unilateral facial nerve paralysis that there was no obvious cause. The patient eventually was discharged from hospital with an outpatient therapy of corticosteroid for 3 weeks, the regular courses of physical rehabilitation for the facial muscles weakness and recommendation to return for follow up in the future. Finally, after 4 months of treatment, the patient's facial weakness disappeared thoroughly without complication. In most cases, Bell's palsy has a good prognosis and the patients will recover with outpatient therapy without complication.

show abstract

Role of Nitric Oxide in the Onset of Facial Nerve Palsy by HSV-1 Infection

Cited by 11 publications

References 12 publications

Thiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker

Thiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker

Nerve Regeneration in Conditions of HSV‐Infection and an Antiviral Drug Influence

Recovery in 61-Year-Old Male After Bell’s Palsy: A Case Report

Contact Info

Product

Resources

About