Role of nitric oxide on zymosan-induced inhibition of crop emptying in chicks

Takahashi, Maki; Khan, Sakirul; Makino, Ryosuke; Cline, Mark A.; Tachibana, Tetsuya

doi:10.1016/j.cbpa.2021.111057

Cited by 8 publications

(7 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that IP injection of 2.5 mg zymosan derived from Saccharomyces cerevisiae suppressed feeding behavior in chicks ( Table 2 ) ( Tachibana et al, 2020a ). This dose of zymosan also increased the cloacal temperature and reduced the crop emptying rate in chicks ( Tachibana et al, 2020a ; 2021b ; Takahashi et al, 2021 ). Interestingly, zymosan components such as β-glucan, chitin, and mannan had little or no effect on the feeding behavior and crop emptying rate in chicks ( Tachibana et al, 2020a ; 2021b ).…”

Section: Tlrs and Pampsmentioning

confidence: 91%

Section: Bioactive Moleculesmentioning

confidence: 99%

“…In chicks, IP injections of zymosan, flagellin, poly I:C, and resiquimod increased the plasma concentrations of NO 2 – and NO 3 – (NOx, metabolites of NO) ( Takahashi et al, 2021 ; Tachibana et al, 2021a ; 2022c ). Moreover, iNOS mRNA expression could be induced by several PAMPs, including zymosan, poly I:C, and resiquimod ( Takahashi et al, 2021 ; Tachibana et al, 2022c ). Since the iNOS inhibitor S-methylisothiourea (SMT) abolished the zymosan-, poly I;C-, and resiquimod-induced increase in plasma NOx concentrations ( Takahashi et al, 2021 ; Tachibana et al, 2022c ), it can be concluded that these PAMPs induce iNOS, thereby increasing NO production in chicks.…”

Section: Bioactive Moleculesmentioning

confidence: 99%

“…Moreover, iNOS mRNA expression could be induced by several PAMPs, including zymosan, poly I:C, and resiquimod ( Takahashi et al, 2021 ; Tachibana et al, 2022c ). Since the iNOS inhibitor S-methylisothiourea (SMT) abolished the zymosan-, poly I;C-, and resiquimod-induced increase in plasma NOx concentrations ( Takahashi et al, 2021 ; Tachibana et al, 2022c ), it can be concluded that these PAMPs induce iNOS, thereby increasing NO production in chicks. Moreover, IP and ICV injections of sodium nitroprusside, an NO donor, significantly reduced food intake in chicks ( Takahashi et al, 2022 ).…”

Section: Bioactive Moleculesmentioning

confidence: 99%

See 3 more Smart Citations

Biomolecules Triggering Altered Food Intake during Pathogenic Challenge in Chicks

Tachibana

Cline

2023

J. Poult. Sci.

Self Cite

View full text Add to dashboard Cite

Food intake is regulated by several complicated synergistic mechanisms that are affected by a variety of internal and external influences. Some of these factors include those that are released from pathogens such as bacteria, fungi, and viruses, and most of these factors are associated with suppression of the chick's food intake. Although chicks are well-known to decrease their food intake when they experience a pathogenic challenge, the mechanisms that mediate this type of satiety are poorly understood. One of the goals of our research group has been to better understand these mechanisms in chicks. We recently provided evidence that pathogen-associated molecular patterns, which are recognized by pattern-recognition receptors such as Toll-like receptors, likely contribute to satiety in chicks that are experiencing a pathogenic challenge. Additionally, we identified several inflammatory cytokines, including interleukin-1β, tumor necrosis factor-like cytokine 1A, prostaglandins, and nitric oxide, that likely contribute to satiety during a pathogenic challenge. This review summarizes the current knowledge on pathogen-induced satiety in chicks mainly accumulated through our recent research. The research will give good information to improve the loss of production during infection in poultry production in the future.

show abstract

Section: Tlrs and Pampsmentioning

confidence: 91%

Section: Bioactive Moleculesmentioning

confidence: 99%

Section: Bioactive Moleculesmentioning

confidence: 99%

Section: Bioactive Moleculesmentioning

confidence: 99%

See 2 more Smart Citations

Biomolecules Triggering Altered Food Intake during Pathogenic Challenge in Chicks

Tachibana

Cline

2023

J. Poult. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Similar to mammals, PAMPs activate the innate immune system and induce non-specific symptoms in chickens. Intraperitoneal (IP) injections of LPS and zymosan induce anorexia, change the cloacal temperature, and inhibit crop emptying in chickens[ 13 , 14 , 15 , 16 ]. As these effects are similar to those observed in mammalian studies, PAMPs may also induce hepatic injury in birds.…”

Section: Introductionmentioning

confidence: 99%

D-Galactosamine Causes Liver Injury Synergistically with Lipopolysaccharide but not Zymosan in Chicks

Takahashi,

Senga,

Teraoka

et al. 2023

J. Poult. Sci.

Self Cite

View full text Add to dashboard Cite

The pathogen-associated molecular patterns (PAMPs) lipopolysaccharide (LPS) and zymosan, derived from gram-negative bacteria and fungi, respectively, activate the innate immune system and cause injury to multiple organs, including the liver and intestine, in mammals. In rodents, PAMP-induced injury has been demonstrated to be potentiated by co-administration of D-galactosamine (D-GalN) in rodents. However, whether PAMPs and D-GalN collectively cause organ injury in birds remains unclear. The present study aimed to measure the effects of intraperitoneal injection of D-GalN with LPS or zymosan on parameters related to hepatic injury in chicks ( Gallus gallus ). Plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) activities were not affected by intraperitoneal injection of D-GalN alone. Although these activities were not affected by LPS injection alone, they were increased by combining LPS with D-GalN. In contrast, plasma AST, ALT, and LDH activities were not affected by zymosan, both alone and with D-GalN. The expression of mRNAs for interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS) in the liver was significantly increased by the combination of LPS and D-GalN. In contrast, combining zymosan with D-GalN significantly increased iNOS mRNA expression, irrespective of hepatic injury. These results suggest that IL-6 may be the cause and/or result of hepatic injury in chicks. Additionally, chicks are tolerant to the hepatic effects of D-GalN, LPS, or zymosan alone.

show abstract

Poly I:C and R848 facilitate nitric oxide production via inducible nitric oxide synthase in chicks

Tachibana

Takahashi

Khan

et al. 2022

Comparative Biochemistry and Physiology Part A: Molecular &

View full text Add to dashboard Cite

Role of nitric oxide on zymosan-induced inhibition of crop emptying in chicks

Cited by 8 publications

References 44 publications

Biomolecules Triggering Altered Food Intake during Pathogenic Challenge in Chicks

Biomolecules Triggering Altered Food Intake during Pathogenic Challenge in Chicks

D-Galactosamine Causes Liver Injury Synergistically with Lipopolysaccharide but not Zymosan in Chicks

Poly I:C and R848 facilitate nitric oxide production via inducible nitric oxide synthase in chicks

Contact Info

Product

Resources

About