Role of nitrosative and oxidative stress in neuropathy in patients with type 2 diabetes mellitus

Al-Nimer, Marwan S.M.; Al-Ani, Fakhir S.; Ali, Fatima S

doi:10.4103/0976-3147.91932

Cited by 36 publications

(27 citation statements)

References 20 publications

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“…Diabetic neuropathy is a common complication that affects sensory neurons, motor neurons, and the autonomic nervous system. Diabetic pain is one of the most common symptoms of diabetic neuropathy and is characterised by spontaneous pain, hyperalgesia, and paraesthesias 1, 2. The mechanism that underlies diabetic pain is complicated.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Attenuates Diabetic Neuropathic Pain by Downregulating TNF-α in a Rat Model

Zhang²,

Liu³

et al. 2013

Int. J. Med. Sci.

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The mechanisms involved in diabetic neuropathic pain are complex and involve peripheral and central pathophysiological phenomena. Proinflammatory tumour necrosis factor α (TNF-α) and TNF-α receptor 1, which are markers of inflammation, contribute to neuropathic pain. The purpose of this experimental study was to evaluate the effect of curcumin on diabetic pain in rats. We tested 24 rats with diabetes induced by a single intraperitoneal injection of streptozotocin and 24 healthy control rats. Twelve rats in each group received 60 mg/kg oral curcumin daily for 28 days, and the other 12 received vehicle. On days 7, 14, 21, and 28, we tested mechanical allodynia with von Frey hairs and thermal hyperalgesia with radiant heat. Markers of inflammation in the spinal cord dorsal horn on day 28 were estimated with a commercial assay and Western blot analysis. Compared to control rats, diabetic rats exhibited increased mean plasma glucose concentration, decreased mean body weight, and significant pain hypersensitivity, as evidenced by decreased paw withdrawal threshold to von Frey hairs and decreased paw withdrawal latency to heat. Curcumin significantly attenuated the diabetes-induced allodynia and hyperalgesia and reduced the expression of both TNF-α and TNF-α receptor 1. Curcumin seems to relieve diabetic hyperalgesia, possibly through an inhibitory action on TNF-α and TNF-α receptor 1.

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Section: Introductionmentioning

confidence: 99%

Curcumin Attenuates Diabetic Neuropathic Pain by Downregulating TNF-α in a Rat Model

Zhang²,

Liu³

et al. 2013

Int. J. Med. Sci.

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“…The peroxynitrite assay was determined, as previously described in Refs. and . Results were expressed as μmol/gr wet weight.…”

Section: Methodsmentioning

confidence: 99%

Radioprotective effect of thymoquinone on salivary gland of rats exposed to total cranial irradiation

et al. 2017

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“…Results were expressed as µmol/ gr wet weight. ONOOassay was determined as described (25,26). Ten microlitre of samples was added to 5 mM phenol in 50 mM sodium phosphate buffer (pH 7.4) to get a final volume of 2 mL.…”

Section: Determination Of Mda No • and Onoolevelsmentioning

confidence: 99%

Thymoquinone Reduces Oxidative and Nitrosative Stress in Tongue Tissue of Rats Exposed to Total Cranial Irradiation

Taysı¹,

Baysal²,

Demir³

et al. 2016

West Indian Med J

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Introduction: Head and neck cancer patients treated with radiotherapy suffer severe side-effects during and following their treatment. Efforts to decrease toxicity of irradiation to normal tissue, organs and cells have led to a search for cytoprotective agent. Investigations for effective and non-toxic compounds with radioprotective capability led to increasing interest in antioxidant such as thymoquinone (TQ). Objective: The aim of this study was to evaluate the radioprotective effects of TQ on oxidant/antioxidant systems in the tongue-tissue of rats exposed to total cranial irradiation. Materials and Methods: Thirty-two rats were divided into four groups to test the radioprotective effectiveness of TQ administered by either orogastric tube or intraperitoneal injection. Appropriate control groups were also studied. Results: Tongue glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), total superoxide scavenger activity (TSSA), non-enzymatic superoxide scavenger activity (NSSA), and superoxide dismutase (SOD) activities in the control and sham control groups were significantly increased when compared to the irradiation (IR) group and IR plus TQ groups. Nitric oxide (NO •), peroxynitrite (ONOO-) and malondialdehyde (MDA) levels, xantine oxidase (XO) and nitric oxide synthase (NOS) activities significantly increased in the IR group when compared to the control and sham control groups. Conclusion: Results show that TQ has the radioprotective, antioxidant effects and free radical scavenging activity. Therapy with antioxidants may lead to the increase in the antioxidant defense system and thus, may decrease the clinical symptoms in radiation therapy.

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Role of nitrosative and oxidative stress in neuropathy in patients with type 2 diabetes mellitus

Cited by 36 publications

References 20 publications

Curcumin Attenuates Diabetic Neuropathic Pain by Downregulating TNF-α in a Rat Model

Curcumin Attenuates Diabetic Neuropathic Pain by Downregulating TNF-α in a Rat Model

Radioprotective effect of thymoquinone on salivary gland of rats exposed to total cranial irradiation

Thymoquinone Reduces Oxidative and Nitrosative Stress in Tongue Tissue of Rats Exposed to Total Cranial Irradiation

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