Role of Nrf2 in the pathogenesis of atherosclerosis

Mimura, Junsei; Itoh, Ken

doi:10.1016/j.freeradbiomed.2015.06.019

Cited by 127 publications

(99 citation statements)

References 158 publications

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“…In addition, several lines of evidence have revealed the contribution of Nrf2 to anti-inflammatory responses. Impaired Nrf2 functions result in prolonged inflammation, which is associated with various disorders, including neurodegeneration and arteriosclerosis (Mimura and Itoh, 2015; Yamazaki et al, 2015). Although direct evidence has not been provided, it is likely that sMAFs are involved in disease prevention together with NRF2.…”

Section: Smaf Functions and Diseasesmentioning

confidence: 99%

Small Maf proteins (MafF, MafG, MafK): History, structure and function

Katsuoka

Yamamoto

2016

Gene

204

152

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The small Maf proteins (sMafs) are basic region leucine zipper (bZIP)-type transcription factors. The basic region of the Maf family is unique among the bZIP factors, and it contributes to the distinct DNA-binding mode of this class of proteins. MafF, MafG and MafK are the three vertebrate sMafs, and no functional differences have been observed among them in terms of their bZIP structures. sMafs form homodimers by themselves, and they form heterodimers with cap ‘n’ collar (CNC) proteins (p45 NF-E2, Nrf1, Nrf2, and Nrf3) and also with Bach proteins (Bach1 and Bach2). Because CNC and Bach proteins cannot bind to DNA as monomers, sMafs are indispensable partners that are required by CNC and Bach proteins to exert their functions. sMafs lack the transcriptional activation domain; hence, their homodimers act as transcriptional repressors. In contrast, sMafs participate in transcriptional activation or repression depending on their heterodimeric partner molecules and context. Mouse genetic analyses have revealed that various biological pathways are under the regulation of CNC-sMaf heterodimers. In this review, we summarize the history and current progress of sMaf studies in relation to their partners.

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Section: Smaf Functions and Diseasesmentioning

confidence: 99%

Small Maf proteins (MafF, MafG, MafK): History, structure and function

Katsuoka

Yamamoto

2016

Gene

204

152

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“…However, depending on the mouse model used and cell type analyzed or even sex of animals, Nrf2 showed both pro-and antiatherogenic properties. 29 Wire injury induces higher neointima formation in Nfe2l2 −/− mice than in control animals. 30,31 43 can also aggravate plaque formation.…”

mentioning

confidence: 92%

Reactive Oxygen Species Generation and Atherosclerosis

Nowak

Deng

Ruan

et al. 2017

ATVB

136

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“…Contudo, atualmente é amplamente aceito que o estresse oxidativo e a inflamação crônica desempenham um papel importante na fisiopatologia do DM2, contribuindo para a disfunção e morte das células β pancreáticas e também para o desenvolvimento das complicações clínicas da doença 3,4 . Neste sentido, o fator nuclear eritroide 2 relacionado ao fator 2 (Nrf2) desempenha um importante papel na fisiopatologia de vários distúrbios mediados pelo estresse oxidativo e inflamação, incluindo o DM2 5 . Assim, o papel que o Nrf2 desempenha na fisiopatologia do DM tem sido alvo de intensa investigação.…”

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O papel do fator nuclear eritroide 2 relacionado ao fator 2 (Nrf2) no diabetes mellitus

Hahn¹,

Oliveira²,

Bock³

2017

Clin. Biomed. Res.

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RESUMOO diabetes mellitus (DM) é uma doença metabólica complexa. Sua etiologia é atribuída a uma combinação entre fatores genéticos, ambientais e de estilo de vida. Contudo, sabe-se que o estresse oxidativo desempenha papel crucial na patogênese do DM, acarretando em disfunção das células β pancreáticas e resistência à insulina. Neste contexto, o fator nuclear eritroide 2 relacionado ao fator 2 (Nrf2) é considerado o regulador mestre da resposta antioxidante do organismo, sendo um mecanismo de importância crítica para a manutenção da homeostase e sobrevivência celular. Todavia, a função do Nrf2 não se limita somente à resposta antioxidante. Ao interagir com outras vias metabólicas, o Nrf2 possui importante papel na regulação do metabolismo, atuando no metabolismo dos lipídios, manutenção da glicemia, resposta inflamatória, entre outros. Entretanto, a exata relação do Nrf2 com outras vias metabólicas ainda não é totalmente conhecida. Contudo, sabe-se que o comprometimento da função do Nrf2 é evidente na fisiopatologia do DM bem como no desenvolvimento de suas complicações clínicas. A ativação do Nrf2 protege contra os danos mediados pelo DM, podendo ser adequada uma intervenção exógena para aumentar a sua atividade. Palavras-chave: Complicações do diabetes; estresse oxidativo; antioxidantes; inflamação; obesidade ABSTRACTDiabetes mellitus (DM) is a complex metabolic disease. Its etiology is attributed to a combination of genetic, environmental, and lifestyle factors. However, it is known that oxidative stress plays a crucial role in the pathogenesis of DM, leading to pancreatic β-cell dysfunction and insulin resistance. In this context, the nuclear factor-erythroid 2-related factor 2 (Nrf2) is considered the main regulator of the body's antioxidant response, being a mechanism of critical importance in the maintenance of homeostasis and cell survival. However, the role of Nrf2 is not limited to the antioxidant response alone. When interacting with other metabolic pathways, Nrf2 plays an important role in regulating metabolism, acting on lipid metabolism, in the maintenance of glycemia, and in inflammatory response, among others. However, the exact relationship of Nrf2 with other metabolic pathways is not yet fully understood. Nevertheless, impairment of Nrf2 function is known to be evident in the pathophysiology of DM as well as in the development of its clinical complications. Activation of the Nrf2 protects against damage mediated by DM, and an exogenous intervention may be adequate to increase its activity. Keywords: Diabetes complications; oxidative stress; antioxidants; inflammation; obesityO diabetes mellitus (DM) é uma doença metabólica crônica e progressiva que apresenta severas complicações. A sua principal característica clínica é a hiperglicemia crônica resultante de defeitos na secreção e/ou ação da insulina. De tal modo, a exposição crônica à hiperglicemia conduz a danos, disfunção e falência de diversos órgãos, afetando especialmente o coração, rins, olhos, nervos, ilhotas pancreáticas e vasos sanguí...

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Role of Nrf2 in the pathogenesis of atherosclerosis

Cited by 127 publications

References 158 publications

Small Maf proteins (MafF, MafG, MafK): History, structure and function

Small Maf proteins (MafF, MafG, MafK): History, structure and function

Reactive Oxygen Species Generation and Atherosclerosis

O papel do fator nuclear eritroide 2 relacionado ao fator 2 (Nrf2) no diabetes mellitus

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