Role of Nucleic Acids in the Regulation of Human Placental Lactogen Synthesis

Gusseck, David J.

doi:10.1159/000301049

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…6,7 To support maternal cardiometabolic adaptations to pregnancy, the placenta secretes large quantities of hormones into the maternal circulation, a process that requires considerable ATP input. For example, human placental lactogen (hPL) production by the term placenta reaches 1 to 4 g/d, 8 which requires approximately 366 mg of ATP for hPL protein synthesis. 9 Therefore, high ATPconsuming processes such as protein synthesis 10 and nutrient transport 11,12 are impaired in placentas with preeclampsia with ensuing FGR.…”

Section: Bioenergeticsmentioning

confidence: 99%

Placental energy metabolism in health and disease—significance of development and implications for preeclampsia

Aye

Aiken

Charnock‐Jones

et al. 2022

American Journal of Obstetrics and Gynecology

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Expert Review ajog.org Central carbon metabolism and its contribution to bioenergetic and biosynthetic processes Key metabolic pathways involved in the generation of ATP and biosynthetic precursors from nutrients. The description of the metabolic pathways is discussed in the main text. The glycolytic shunt pathways: pentose phosphate pathway and hexosamine biosynthetic pathway are shaded in yellow and pink, respectively. Cofactors are depicted in blue and orange, and biosynthetic precursors are shown in red.

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Section: Bioenergeticsmentioning

confidence: 99%

Placental energy metabolism in health and disease—significance of development and implications for preeclampsia

Aye

Aiken

Charnock‐Jones

et al. 2022

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

show abstract

“…Thus, it seems extremely difficult to obtain undegraded mRNA from human placenta, in spite of all the precautions taken to inhibit ribonuclease action. A possible explanation could be the unusually high level of endogenous RNAse activity found in the placenta, which may result from lysosome activation during labor and the postdelivery period [28].…”

Section: Isolation Ojplacenta1 M R N Amentioning

confidence: 99%