Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: An Indian consensus statement

Dalal, Jamshed; Kasliwal, Ravi R; Dutta, Anjan; Sawhney, Jps; Iyengar, S. S.; Dani, Sameer; Desai, Nihar; Sathyamurthy, I; Rao, D; Menon, Ajit; Dasbiswas, Arup; Wander, Gurpreet Singh; Chadha, Manoj; Hiremath, M.S.; Roy, Debabrata; Gupta, Vineet Bhushan; Shivakadaksham, N.

doi:10.1016/j.ihj.2012.08.004

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Another study demonstrated that omega-3 ethyl esters have clinically proven benefits in improving post-myocardial infarction (MI) outcomes, such as significant 15% risk reduction for all-cause mortality together with 20% risk reduction for CVDs [ 8 , 9 ]. The in-hospital mortality due to AMI has been reduced by approximately 30% over the last 20 years [ 10 ]. According to the current guidelines of the European Society of Cardiology, treatment with omega-3 PUFAs may be considered a new option to add to the shortlist of evidence-based life-prolonging therapies for heart failure [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders—A Review

et al. 2018

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Cardiovascular diseases are described as the leading cause of morbidity and mortality in modern societies. Therefore, the importance of cardiovascular diseases prevention is widely reflected in the increasing number of reports on the topic among the key scientific research efforts of the recent period. The importance of essential fatty acids (EFAs) has been recognized in the fields of cardiac science and cardiac medicine, with the significant effects of various fatty acids having been confirmed by experimental studies. Polyunsaturated fatty acids are considered to be important versatile mediators for improving and maintaining human health over the entire lifespan, however, only the cardiac effect has been extensively documented. Recently, it has been shown that omega-3 fatty acids may play a beneficial role in several human pathologies, such as obesity and diabetes mellitus type 2, and are also associated with a reduced incidence of stroke and atherosclerosis, and decreased incidence of cardiovascular diseases. A reasonable diet and wise supplementation of omega-3 EFAs are essential in the prevention and treatment of cardiovascular diseases prevention and treatment.

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Section: Introductionmentioning

confidence: 99%

Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders—A Review

et al. 2018

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Breast Cancer Genetic and Molecular Subtype Impacts Response to Omega-3 Fatty Acid Ethyl Esters

Chen

Fabian

Hursting

et al. 2016

Nutrition and Cancer

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Epidemiological studies have correlated frequent omega-3 (n-3) fatty acid consumption with a lower risk for breast cancer; however, recent prospective studies have been less conclusive. Efforts in the preventive setting have focused on the use of n-3 fatty acids, and the pharmaceutical ethyl esters (EE) of these natural compounds, for high-risk patient populations. Limited understanding of specific mechanisms by which these agents function has hampered identification of the cancer subtype(s) that would gain the greatest therapeutic benefit. In this study, we investigated the in vitro effects of n-3 EEs in four distinct breast cancer subtypes and explored how they affect not only breast cancer cell survival but also modulate the nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) and peroxisome proliferator-activated receptor gamma signaling pathways. Similar to the high variance in response observed in human studies, we found that the effectiveness of n-3 EEs depends on the molecular characteristics of the MCF-7, CAMA-1, MDA-MB-231, and SKBR3 breast cancer cell lines and is closely associated with the suppression of NF-κB. These data strongly suggest that the use of n-3 fatty acids and their pharmaceutical ether esters in the prevention and therapeutic setting should be guided by specific tumor characteristics.

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Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: An Indian consensus statement

Cited by 2 publications

References 25 publications

Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders—A Review

Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders—A Review

Breast Cancer Genetic and Molecular Subtype Impacts Response to Omega-3 Fatty Acid Ethyl Esters

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