2006
DOI: 10.2174/138161206776055895
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Role of Opioid Antagonists in the Treatment of Women with Glucoregulation Abnormalities

Abstract: Beta-endorphin were detected in the endocrine pancreas and seem able to influence insulin and glucagon release. Hence, endogenous opioids could have a role in glucoregulation and in the pathogenesis of obesity beyond the previously detected effects on appetite. Metabolic abnormalities, such as hyperinsulinemia, insulin-resistance and obesity, are common features of polycystic ovary syndrome (PCOS), and seem to have a pathogenetic role in this disorder. A link between opioids and PCOS-related hyperinsulinism is… Show more

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Cited by 27 publications
(28 citation statements)
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“…24 Such metabolic abnormalities have also been reported previously due to a link between opioids and PCOS-related insulin response to glucose load. 25,26 Similar abnormalities have been additionally indicated in the animal model PCOS. [27][28][29] This study may further show the NO overproduction as harmful for Wistar rat reproduction.…”
Section: Ijifmsupporting
confidence: 57%
“…24 Such metabolic abnormalities have also been reported previously due to a link between opioids and PCOS-related insulin response to glucose load. 25,26 Similar abnormalities have been additionally indicated in the animal model PCOS. [27][28][29] This study may further show the NO overproduction as harmful for Wistar rat reproduction.…”
Section: Ijifmsupporting
confidence: 57%
“…Similar considerations apply to other common disease combinations in multimorbid patients with CP, such as the treatment of diabetes mellitus (23.1% in this study) and its effect on chronic neuropathic pain. Endogenous opioids also have a role in the regulation of blood glucose and hyperinsulinemia [57], and it is conceivable that exogenous opioids, such as morphine, may affect this regulation.…”
Section: Discussionmentioning
confidence: 99%
“…Compared to placebo, naltrexone resulted in an overall increase in blood glucose levels. Long-term treatment with naltrexone (ā‰„5 weeks; 50 mg) has been reported to improved blood glucose clinical populations with impaired glucose homeostasis [42, 43]. The mechanism of naltrexone's glucoregulatory actions is thought to be mediated, in part, by blockade of endogenous opioid action on the pancreatic islet cells [44, 45].…”
Section: Discussionmentioning
confidence: 99%