Role of oral glycerol in glaucoma.

Awasthi, P; Srivastava, SK

doi:10.1136/bjo.49.12.660

Cited by 11 publications

(5 citation statements)

References 8 publications

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“…For example, it is possible that the trend of decreased IOP would have approached significance had this evaluation included subjects with glaucomatous eyes. This is supported by previous studies, which determined that both isosorbide 22,23 and glycerol 24–26 are significantly more effective at lowering IOP in glaucomatous vs. normotensive human patients. In addition, a more complete assessment of osmolality is necessary to explain the unusual changes in SoSM following both isosorbide (in the study reported here) and glycerol (in the study by Lorimer et al.…”

Section: Discussionsupporting

confidence: 81%

Effects of oral isosorbide and glycerol on intraocular pressure, serum osmolality, and blood glucose in normal dogs

Wasserman

Kennard

Cochrane

et al. 2012

Veterinary Ophthalmology

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Section: Discussionsupporting

confidence: 81%

Effects of oral isosorbide and glycerol on intraocular pressure, serum osmolality, and blood glucose in normal dogs

Wasserman

Kennard

Cochrane

et al. 2012

Veterinary Ophthalmology

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“…6,7 Glycerol has previously been used in stroke, head injury and glaucoma to reduce elevated tissue pressure. 8-16 A meta-analysis of intravenous glycerol in ischaemic stroke suggested short-term advantage but no benefit in terms of long-term survival. 17…”

Section: Introductionmentioning

confidence: 99%

Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV seroprevalence setting in Malawi: a double-blind, randomised controlled trial

Ajdukiewicz

Cartwright

Scarborough

et al. 2011

The Lancet Infectious Diseases

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SummaryBackground-Southern Africa has a high incidence of bacterial meningitis in adults, often associated with HIV co-infection. Even with appropriate antibiotic therapy, mortality exceeds 50% and is not improved with corticosteroids. Glycerol adjuvant therapy reduced mortality and longterm morbidity (deafness) in bacterial meningitis in children and is being promoted. If similarly effective in adults, glycerol would provide a cheap, available adjuvant therapy in Africa.

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“…It has been used in neurosurgery, neurology, and ophthalmology to decrease raised tissue pressures (26,78,87,168,416,501). Toxicological data show that it is safe and is associated with few, rare, mild, mostly gastrointestinal side effects (152).…”

Section: Adjunctive Glycerol Therapymentioning

confidence: 99%

Pathogenesis and Pathophysiology of Pneumococcal Meningitis

et al. 2011

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SUMMARY Pneumococcal meningitis continues to be associated with high rates of mortality and long-term neurological sequelae. The most common route of infection starts by nasopharyngeal colonization by Streptococcus pneumoniae , which must avoid mucosal entrapment and evade the host immune system after local activation. During invasive disease, pneumococcal epithelial adhesion is followed by bloodstream invasion and activation of the complement and coagulation systems. The release of inflammatory mediators facilitates pneumococcal crossing of the blood-brain barrier into the brain, where the bacteria multiply freely and trigger activation of circulating antigen-presenting cells and resident microglial cells. The resulting massive inflammation leads to further neutrophil recruitment and inflammation, resulting in the well-known features of bacterial meningitis, including cerebrospinal fluid pleocytosis, cochlear damage, cerebral edema, hydrocephalus, and cerebrovascular complications. Experimental animal models continue to further our understanding of the pathophysiology of pneumococcal meningitis and provide the platform for the development of new adjuvant treatments and antimicrobial therapy. This review discusses the most recent views on the pathophysiology of pneumococcal meningitis, as well as potential targets for (adjunctive) therapy.

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Role of oral glycerol in glaucoma.

Cited by 11 publications

References 8 publications

Effects of oral isosorbide and glycerol on intraocular pressure, serum osmolality, and blood glucose in normal dogs

Effects of oral isosorbide and glycerol on intraocular pressure, serum osmolality, and blood glucose in normal dogs

Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV seroprevalence setting in Malawi: a double-blind, randomised controlled trial

Pathogenesis and Pathophysiology of Pneumococcal Meningitis

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