Role of oral microbiome on oral cancers, a review

Gholizadeh, Pourya; Eslami, Hosein; Yousefi, Mehdi; Asgharzadeh, Mohammad; Aghazadeh, Mohammad; Kafil, Hossein Samadi

doi:10.1016/j.biopha.2016.09.082

Cited by 210 publications

(181 citation statements)

References 82 publications

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“…19,36–38 Likewise, oral bacterial dysbiosis, particularly involving Porphyromonas gingivalis and F. nucleatum, have been implicated in the development of oral cancer in human and animal studies. 39–41 Possible mechanisms include the induction of chronic inflammation, 40,42,43 promotion of cellular invasion, 40 and direct production of carcinogens. 40,44,45 These local mechanisms that promote bacterial carcinogenesis could also affect tumor behavior and influence patient survival.…”

Section: Discussionmentioning

confidence: 99%

Poor oral health affects survival in head and neck cancer

et al. 2017

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Introduction Poor oral health has emerged as a risk factor for squamous cell carcinoma of the head and neck (HNSCC) but its impact on survival has not been examined. We sought to estimate the impact of oral health indicators on survival in a population-based HNSCC cohort. Materials and Methods Cases (n=1381) and age-, sex- and race-matched controls (n=1396) were participants in the Carolina Head and Neck Cancer Epidemiologic Study (CHANCE). Vital status was determined via linkage with the National Death Index. Survival was considered at 5 years post-diagnosis or study-enrollment for controls. Oral health was assessed using self-reported indicators including frequency of routine dental exams and tooth brushing. We used Kaplan-Meyer analyses and Cox regression to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI). Results Routine dental visits during the preceding 10 years were associated with decreased mortality risk (>10 visits: HR=0.6, 95% CI=0.4–0.8) after adjusting for confounders. This effect was most pronounced for oral cavity cancer—(e.g., >10 visits: HR=0.4, 95% CI=0.2–0.9). Dental visits were also positively associated with survival among controls. No other routine health screening (e.g., eye exams) was associated with survival. Conclusion We found significant associations between markers of oral health and survival among both HNSCC cases and controls. This association was most pronounced for sites closer to the dentition. Oral health may have a direct effect on tumor biology due to the associated immune or inflammatory response. It may also represent a proxy for wellness or unmeasured social determinants of health.

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Section: Discussionmentioning

confidence: 99%

Poor oral health affects survival in head and neck cancer

et al. 2017

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“…Although oral cancer is a multifactorial disease, there are some reports indicating that Candida ‐infected oral lesions have a higher propensity for malignant transformation (Gholizadeh et al., ; Sankari, Gayathri, Balachander, & Malathi, ). The conditions that have been investigated include oral squamous cell carcinoma (OSCC), lichen planus and fibro epithelial polyps.…”

Section: Oral Mycobiome and Oral Carcinomamentioning

confidence: 99%

Biodiversity of the human oral mycobiome in health and disease

2018

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The organisms that colonize the human body over a lifetime are diverse, extensive and gargantuan. A fair proportion of the microbiota that constitutes this human microbiome live within our oral cavities mostly as harmonious associates causing only sporadic disease. An important core constituent of the microbiome is the mycobiome, representing various fungal genera. Up until recently, only a few species of fungi, mainly Candida species, were thought to constitute the human oral mycobiome. The reasons for this are manifold, although the uncultivable nature of many fungi in conventional laboratory media, and their complex genetic composition seem to be the major factors which eluded their detection over the years. Nevertheless, recent advances in computing and high-throughput sequencing such as next-generation sequencing (NGS) platforms have provided us a panoramic view of a totally new world of fungi that are human oral cohabitués. Their diversity is perplexing, and functionality yet to be deciphered. Here, we provide a glimpse of what is currently known of the oral mycobiome, in health and disease, with some future perspectives.

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“…The incidence of bacteremia and related systemic diseases due to oral anaerobic bacteria following different procedures such as: endodontic treatment, tooth extraction, periodontal surgery, tongue scraping and root scaling has been well documented [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] and anaerobe periodontal bacteria are isolated more frequently than facultative anaerobic bacteria, such as Streptococcus spp. [28].…”

Section: Oral Surgery and Risk For Bacteremiamentioning

confidence: 99%

Oral Surgery in the Human Microbiota Era the role of Periodontal Bacteria

Mascolo¹

2017

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Role of oral microbiome on oral cancers, a review

Cited by 210 publications

References 82 publications

Poor oral health affects survival in head and neck cancer

Poor oral health affects survival in head and neck cancer

Biodiversity of the human oral mycobiome in health and disease

Oral Surgery in the Human Microbiota Era the role of Periodontal Bacteria

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