Role of Oral Pathogens in the Pathogenesis of Coronary Heart Disease

Holmstrup, Palle

doi:10.1002/9780470692325.ch26

Cited by 3 publications

(2 citation statements)

References 55 publications

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“…Aside from direct spreading, dental biofilm bacteria may influence other parts of the body and contribute to systemic diseases in a more indirect manner. A number of epidemiologic studies have shown a correlation between periodontitis and diabetes mellitus, atherosclerosis, and rheumatoid arthritis . This can be explained by the effect of inflammatory mediators induced by periodontal pathogens in subgingival biofilms and subsequently distributed systemically.…”

Section: Bacteria In Dental Biofilms and Systemic Diseasesmentioning

confidence: 99%

Dental biofilm infections – an update

Larsen

Fiehn

2017

APMIS

272

167

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Teeth are colonized by oral bacteria from saliva containing more than 700 different bacterial species. If removed regularly, the dental biofilm mainly comprises oral streptococci and is regarded as resident microflora. But if left undisturbed, a complex biofilm containing up to 100 bacterial species at a site will build up and may eventually cause development of disease. Depending on local ecological factors, the composition of the dental biofilm may vary considerably. With access to excess carbohydrates, the dental biofilm will be dominated by mainly gram‐positive carbohydrate‐fermenting bacteria causing demineralization of teeth, dental caries, which may further lead to inflammation and necrosis in the pulp and periapical region, i.e., pulpitis and periapical periodontitis. In supra‐ and subgingival biofilms, predominantly gram‐negative, anaerobic proteolytic bacteria will colonize and cause gingival inflammation and breakdown of supporting periodontal fibers and bone and ultimately tooth loss, i.e., gingivitis, chronic or aggressive periodontitis, and around dental implants, peri‐implantitis. Furthermore, bacteria from the dental biofilm may spread to other parts of the body by bacteremia and cause systemic disease. Basically, prevention and treatment of dental biofilm infections are achieved by regular personal and professional removal of the dental biofilm.

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Section: Bacteria In Dental Biofilms and Systemic Diseasesmentioning

confidence: 99%

Dental biofilm infections – an update

Larsen

Fiehn

2017

APMIS

272

167

View full text Add to dashboard Cite

show abstract

“…et er efterhånden fastslået, at de immunologiske anomalier, som ligger til grund for arteriosklerose, som sammen med hypertension er den mest udbredte hjerte-kar-sygdom, har en faelles baggrund med en raekke odontologiske sygdomme som fx marginal parodontitis og gingivitis (1,2). Dette aspekt vil blive beskrevet under parodontitis og kardiovaskulaer sygdom i en efterfølgende artikel i dette tema om patienter med svaekket helbred i Tandlaegebladet.…”

Section: Kardiovaskulaer Sygdom Og Odontologiunclassified