Role of Oral Supplementation of Damiana (Turnera diffusa) Reduces the Renal Toxicity, Apoptosis and DNA Damage Associated with Amitriptyline Administration in Rats

Abstract

Major depressive disorder and anxiety disorders are two mental diseases that are treated with amitriptyline (AMT). AMT treatments induced liver, heart and testes toxicity; As a result, the purpose of this study was to determine the preventative and therapeutic role of damiana (Dam) as adjuvant herbal therapy against AMT induced heart injury in rats. Six groups of 36 rats (male albino) were randomly assigned; first one is control, second is Dam, third was AMT, fourth was Dam+AMT, fifth was AMT+Dam and sixth was AMT self-healing. A significant elevation in creatinine, urea, sodium (Na+), Chloride (Cl+), renal injury, DNA damage and apoptosis in treatment rats with amitriptyline and self-healing group as related to control and damiana groups. Conversely; potassium (K+) and calcium (Ca++) were a significant decrease in AMT and self-healing groups as compared with control. Treatment of AMT with Dam (Co and Post) revealed a modulation and improvement of renal toxicity with best result in co- treatments than post treatments. As a result, AMT treatments encouraged changes in kidney functions and structure and the post-treatments of AMT with dam modulates these alterations.

Evaluation of the renal protection conferred by amygdalin against animal growth regulator Boldjan induced renal toxicity and injury in male rats

“…Our findings also corroborate the findings of Hoseini et al [29] and Tousson et al [37], which showed that nandrolone decanoate caused renal impairment in mice. Treatment with herbal medicine improved kidney function and structure [38].…”

Orlistat Induce Renal Toxicity, DNA Damage, and Apoptosis in Normal and Obese Female Rats

“…The regulation of the two univalent cations of fundamental physiological relevance, potassium, and sodium, throughout the body is one of the kidney's key roles (Alm-Eldeen and Tousson, 2012;Hasan et al, 2022). The metabolism of calcium is a subject that the kidney takes very seriously (Salama et al, 2013).…”

Effect of treatment with essential oils on the liver toxicity induced by Ehrlich ascites carcinoma in female mouse model

“…The liver and brain tissues of all groups were excised, fixed in 10% formalin for a period between (24-48 hours), dehydrated in ascending alcohol concentrations, paraffin wax infiltrated and then were cut at 5 m sections to be mounted on glass slides. Then, the slide tissue sections were deparaffinized and hydrated again then stained with hematoxylin and eosin (H&E) for histological examination by light microscopy according to Hameed et al (2022) andFatoh et al (2023).…”